ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	194/1094	423/7206	7.55194605263e-55
ko05033	Nicotine addiction	49/1094	56/7206	2.38635511408e-33
ko04724	Glutamatergic synapse	86/1094	152/7206	9.62369974845e-33
ko05032	Morphine addiction	66/1094	110/7206	2.18262182069e-27
ko04713	Circadian entrainment	72/1094	136/7206	3.9467168745e-25
ko04727	GABAergic synapse	63/1094	110/7206	1.2781322018e-24
ko04725	Cholinergic synapse	75/1094	160/7206	6.76456637926e-22
ko04728	Dopaminergic synapse	81/1094	185/7206	3.35636177927e-21
ko04723	Retrograde endocannabinoid signaling	76/1094	175/7206	1.07761254996e-19
ko04024	cAMP signaling pathway	101/1094	279/7206	1.0345192774e-18
ko04721	Synaptic vesicle cycle	45/1094	80/7206	1.69956106241e-17
ko04020	Calcium signaling pathway	94/1094	265/7206	6.98110583117e-17
ko04744	Phototransduction	27/1094	36/7206	1.3989649741e-15
ko04726	Serotonergic synapse	58/1094	137/7206	1.08176338826e-14
ko04742	Taste transduction	35/1094	61/7206	3.01419453878e-14
ko04911	Insulin secretion	51/1094	117/7206	1.12278957412e-13
ko04921	Oxytocin signaling pathway	73/1094	209/7206	6.01457757552e-13
ko04720	Long-term potentiation	42/1094	99/7206	5.01083234299e-11
ko04261	Adrenergic signaling in cardiomyocytes	67/1094	205/7206	1.69399616642e-10
ko05031	Amphetamine addiction	39/1094	91/7206	1.71121343158e-10
ko03040	Spliceosome	1/1094	145/7206	1.36539673263e-09
ko04970	Salivary secretion	36/1094	95/7206	4.41261749082e-08
ko05203	Viral carcinogenesis	14/1094	277/7206	1.26310138883e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1094	74/7206	3.94157690882e-07
ko04740	Olfactory transduction	30/1094	80/7206	7.6387549822e-07
ko04360	Axon guidance	64/1094	233/7206	9.68157374447e-07
ko05168	Herpes simplex infection	7/1094	182/7206	1.0402520972e-06
ko05030	Cocaine addiction	28/1094	73/7206	1.04607702711e-06
ko04925	Aldosterone synthesis and secretion	36/1094	105/7206	1.34131814736e-06
ko04070	Phosphatidylinositol signaling system	37/1094	112/7206	1.75930713678e-06
ko05322	Systemic lupus erythematosus	5/1094	151/7206	3.04452621163e-06
ko04971	Gastric acid secretion	33/1094	98/7206	5.23301280291e-06
ko04022	cGMP-PKG signaling pathway	58/1094	216/7206	7.17976862851e-06
ko04621	NOD-like receptor signaling pathway	6/1094	157/7206	7.9028674427e-06
ko04060	Cytokine-cytokine receptor interaction	9/1094	191/7206	8.01065673436e-06
ko03013	RNA transport	7/1094	166/7206	8.93232434227e-06
ko04010	MAPK signaling pathway	78/1094	321/7206	1.07397274973e-05
ko04514	Cell adhesion molecules (CAMs)	39/1094	130/7206	1.78507720422e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1094	79/7206	2.21896188754e-05
ko04745	Phototransduction - fly	16/1094	38/7206	5.79047971799e-05
ko04141	Protein processing in endoplasmic reticulum	10/1094	184/7206	6.13053900735e-05
ko04072	Phospholipase D signaling pathway	51/1094	197/7206	7.3264571657e-05
ko05164	Influenza A	9/1094	167/7206	0.000111597196088
ko04110	Cell cycle	7/1094	145/7206	0.000146589665286
ko04730	Long-term depression	25/1094	78/7206	0.000170666233632
ko04972	Pancreatic secretion	32/1094	111/7206	0.000241761565409
ko04064	NF-kappa B signaling pathway	3/1094	96/7206	0.000256638831809
ko04120	Ubiquitin mediated proteolysis	7/1094	138/7206	0.000280877659144
ko04260	Cardiac muscle contraction	29/1094	98/7206	0.000291504473848
ko04750	Inflammatory mediator regulation of TRP channels	34/1094	122/7206	0.000293230242338
ko04924	Renin secretion	26/1094	86/7206	0.000373591478801
ko04540	Gap junction	35/1094	128/7206	0.000407410354958
ko03008	Ribosome biogenesis in eukaryotes	2/1094	79/7206	0.000409520024354
ko04014	Ras signaling pathway	64/1094	279/7206	0.000455995502545
ko04612	Antigen processing and presentation	2/1094	77/7206	0.000612627774668
ko05414	Dilated cardiomyopathy	31/1094	112/7206	0.000741944262232
ko04966	Collecting duct acid secretion	11/1094	26/7206	0.000803074667948
ko05140	Leishmaniasis	2/1094	75/7206	0.000928558048
ko04923	Regulation of lipolysis in adipocytes	23/1094	77/7206	0.00107908007012
ko04915	Estrogen signaling pathway	34/1094	131/7206	0.00123465264673
ko05205	Proteoglycans in cancer	23/1094	271/7206	0.00132126431975
ko05169	Epstein-Barr virus infection	16/1094	206/7206	0.00155649247728
ko04610	Complement and coagulation cascades	3/1094	79/7206	0.00233644642907
ko04626	Plant-pathogen interaction	8/1094	18/7206	0.00290200516397
ko00590	Arachidonic acid metabolism	1/1094	52/7206	0.00312207857931
ko04330	Notch signaling pathway	2/1094	62/7206	0.00411876101376
ko00562	Inositol phosphate metabolism	24/1094	89/7206	0.00413629124364
ko05166	HTLV-I infection	28/1094	292/7206	0.00582379920091
ko04930	Type II diabetes mellitus	16/1094	54/7206	0.00647809325806
ko00240	Pyrimidine metabolism	7/1094	110/7206	0.00696455544108
ko03420	Nucleotide excision repair	1/1094	46/7206	0.00701364558631
ko05161	Hepatitis B	14/1094	173/7206	0.00702898722286
ko04146	Peroxisome	5/1094	89/7206	0.00731314951476
ko04371	Apelin signaling pathway	40/1094	177/7206	0.0077579538356
ko04973	Carbohydrate digestion and absorption	13/1094	42/7206	0.00837766721076
ko03022	Basal transcription factors	1/1094	44/7206	0.0104308627826
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1094	100/7206	0.0106417383994
ko05144	Malaria	1/1094	45/7206	0.0106522468744
ko00071	Fatty acid degradation	1/1094	45/7206	0.0106522468744
ko04976	Bile secretion	21/1094	80/7206	0.0109904765919
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1094	14/7206	0.0121392520383
ko00280	Valine, leucine and isoleucine degradation	2/1094	54/7206	0.0126624352785
ko00480	Glutathione metabolism	2/1094	55/7206	0.0128110667943
ko05110	Vibrio cholerae infection	17/1094	63/7206	0.0130755784976
ko04722	Neurotrophin signaling pathway	36/1094	160/7206	0.0136663299448
ko05162	Measles	9/1094	120/7206	0.014592279892
ko00330	Arginine and proline metabolism	3/1094	61/7206	0.0194706015189
ko04622	RIG-I-like receptor signaling pathway	3/1094	62/7206	0.0195771363827
ko04214	Apoptosis - fly	4/1094	72/7206	0.0197003689097
ko00310	Lysine degradation	4/1094	73/7206	0.0201289940037
ko00630	Glyoxylate and dicarboxylate metabolism	1/1094	38/7206	0.023116556752
ko05145	Toxoplasmosis	10/1094	126/7206	0.0232227139407
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1094	40/7206	0.0239902481516
ko04071	Sphingolipid signaling pathway	35/1094	162/7206	0.0263241089588
ko04630	Jak-STAT signaling pathway	11/1094	132/7206	0.0268177096016
ko05217	Basal cell carcinoma	4/1094	68/7206	0.0271295079947
ko05231	Choline metabolism in cancer	30/1094	134/7206	0.0277013850065
ko04062	Chemokine signaling pathway	42/1094	201/7206	0.0277793124732
ko04710	Circadian rhythm	12/1094	43/7206	0.0301784118055
ko04658	Th1 and Th2 cell differentiation	7/1094	96/7206	0.0306049774839
ko05200	Pathways in cancer	58/1094	492/7206	0.0315023000311
ko04964	Proximal tubule bicarbonate reclamation	9/1094	29/7206	0.032120672853
ko04015	Rap1 signaling pathway	55/1094	278/7206	0.0329549574034
ko04657	IL-17 signaling pathway	6/1094	87/7206	0.0337044336817
ko05133	Pertussis	6/1094	87/7206	0.0337044336817
ko05206	MicroRNAs in cancer	17/1094	177/7206	0.0339654741571
ko00982	Drug metabolism - cytochrome P450	1/1094	37/7206	0.035175442658
ko04350	TGF-beta signaling pathway	8/1094	103/7206	0.0368495389359
ko05214	Glioma	19/1094	79/7206	0.038552319952
ko05321	Inflammatory bowel disease (IBD)	3/1094	56/7206	0.0385665258466
ko04142	Lysosome	14/1094	151/7206	0.0390824589697
ko04912	GnRH signaling pathway	27/1094	122/7206	0.0406109645184
ko05230	Central carbon metabolism in cancer	19/1094	81/7206	0.0427779586276
ko05131	Shigellosis	6/1094	82/7206	0.0441102960706
ko03018	RNA degradation	6/1094	84/7206	0.0449556078414
ko04960	Aldosterone-regulated sodium reabsorption	11/1094	41/7206	0.0475460206447
ko04115	p53 signaling pathway	5/1094	74/7206	0.0486851308422