ko pathway ratio_in_study ratio_in_pop p_value ko05322 Systemic lupus erythematosus 63/370 151/7206 1.42984765683e-42 ko05034 Alcoholism 65/370 238/7206 6.50675922487e-31 ko05203 Viral carcinogenesis 57/370 277/7206 1.90303615289e-20 ko03040 Spliceosome 37/370 145/7206 9.60098342167e-17 ko04110 Cell cycle 35/370 145/7206 4.37194799982e-15 ko03440 Homologous recombination 18/370 41/7206 2.79903664142e-13 ko04111 Cell cycle - yeast 25/370 90/7206 1.40596956145e-12 ko03460 Fanconi anemia pathway 17/370 51/7206 2.47373159252e-10 ko03013 RNA transport 30/370 166/7206 9.93491787145e-10 ko04113 Meiosis - yeast 17/370 70/7206 5.36008909956e-08 ko03410 Base excision repair 12/370 38/7206 2.26228892061e-07 ko03030 DNA replication 12/370 38/7206 2.26228892061e-07 ko04144 Endocytosis 1/370 342/7206 4.31014142214e-07 ko03008 Ribosome biogenesis in eukaryotes 16/370 79/7206 1.86424167336e-06 ko03018 RNA degradation 14/370 84/7206 8.20550785774e-05 ko00240 Pyrimidine metabolism 16/370 110/7206 0.000139946807021 ko04114 Oocyte meiosis 18/370 139/7206 0.000247456904672 ko04914 Progesterone-mediated oocyte maturation 15/370 104/7206 0.000247734762054 ko04217 Necroptosis 21/370 178/7206 0.000364031584568 ko04024 cAMP signaling pathway 3/370 279/7206 0.000443696940648 ko03420 Nucleotide excision repair 9/370 46/7206 0.000456419554444 ko05010 Alzheimer's disease 1/370 202/7206 0.00050433358657 ko03430 Mismatch repair 6/370 22/7206 0.000650545047187 ko05202 Transcriptional misregulation in cancer 21/370 188/7206 0.000651433619231 ko04022 cGMP-PKG signaling pathway 2/370 216/7206 0.00148051070942 ko03022 Basal transcription factors 8/370 44/7206 0.00155883912681 ko04151 PI3K-Akt signaling pathway 8/370 390/7206 0.00289822511081 ko04261 Adrenergic signaling in cardiomyocytes 2/370 205/7206 0.00318850153813 ko04724 Glutamatergic synapse 1/370 152/7206 0.00480621658188 ko04218 Cellular senescence 18/370 177/7206 0.00499755099277 ko04621 NOD-like receptor signaling pathway 1/370 157/7206 0.00500350358332 ko05166 HTLV-I infection 26/370 292/7206 0.00612300228072 ko04728 Dopaminergic synapse 2/370 185/7206 0.0061818391649 ko05152 Tuberculosis 2/370 187/7206 0.00628180042976 ko04723 Retrograde endocannabinoid signaling 2/370 175/7206 0.00872173861716 ko04921 Oxytocin signaling pathway 3/370 209/7206 0.00987541407374 ko04713 Circadian entrainment 1/370 136/7206 0.0101383817856 ko04510 Focal adhesion 4/370 240/7206 0.0104018349836 ko00310 Lysine degradation 9/370 73/7206 0.0118969286046 ko04115 p53 signaling pathway 9/370 74/7206 0.0129518966009 ko04072 Phospholipase D signaling pathway 3/370 197/7206 0.0134839345533 ko01200 Carbon metabolism 1/370 128/7206 0.0146865214852 ko04514 Cell adhesion molecules (CAMs) 1/370 130/7206 0.0147372135518 ko04630 Jak-STAT signaling pathway 1/370 132/7206 0.0149531579743 ko04152 AMPK signaling pathway 2/370 161/7206 0.0175349571688 ko04668 TNF signaling pathway 1/370 120/7206 0.0212336783686 ko04750 Inflammatory mediator regulation of TRP channels 1/370 122/7206 0.0212892741244 ko04666 Fc gamma R-mediated phagocytosis 1/370 122/7206 0.0212892741244 ko00190 Oxidative phosphorylation 1/370 127/7206 0.0224333812342 ko04142 Lysosome 2/370 151/7206 0.0245461473965 ko05012 Parkinson's disease 2/370 155/7206 0.0250226927955 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/370 182/7206 0.0258396038227 ko05016 Huntington's disease 4/370 215/7206 0.0262779001479 ko05414 Dilated cardiomyopathy 1/370 112/7206 0.0306345117411 ko04911 Insulin secretion 1/370 117/7206 0.0313782833428 ko04810 Regulation of actin cytoskeleton 6/370 264/7206 0.0316502967569 ko04371 Apelin signaling pathway 3/370 177/7206 0.0361340550965 ko04014 Ras signaling pathway 7/370 279/7206 0.037998897829 ko04530 Tight junction 5/370 228/7206 0.045267201839 ko04727 GABAergic synapse 1/370 110/7206 0.0455908742909 ko05032 Morphine addiction 1/370 110/7206 0.0455908742909 ko04931 Insulin resistance 2/370 137/7206 0.0484218993898 ko04611 Platelet activation 3/370 163/7206 0.0485441646962 ko05205 Proteoglycans in cancer 7/370 271/7206 0.0494498465368