ko pathway ratio_in_study ratio_in_pop p_value ko05322 Systemic lupus erythematosus 74/365 151/7206 5.28054187259e-57 ko05034 Alcoholism 71/365 238/7206 5.1374778367e-37 ko03040 Spliceosome 50/365 145/7206 2.25731341403e-29 ko05203 Viral carcinogenesis 55/365 277/7206 2.89754578887e-19 ko03013 RNA transport 34/365 166/7206 1.23364540565e-12 ko04110 Cell cycle 31/365 145/7206 3.89833530037e-12 ko03008 Ribosome biogenesis in eukaryotes 21/365 79/7206 1.76809796785e-10 ko04111 Cell cycle - yeast 22/365 90/7206 3.79613229607e-10 ko03030 DNA replication 14/365 38/7206 1.82069655878e-09 ko03440 Homologous recombination 12/365 41/7206 4.95445691468e-07 ko04113 Meiosis - yeast 15/365 70/7206 1.5621287671e-06 ko04144 Endocytosis 2/365 342/7206 5.67965942454e-06 ko03430 Mismatch repair 8/365 22/7206 6.86259005639e-06 ko04810 Regulation of actin cytoskeleton 1/365 264/7206 2.20751530398e-05 ko05202 Transcriptional misregulation in cancer 24/365 188/7206 2.3953413496e-05 ko00240 Pyrimidine metabolism 17/365 110/7206 3.33022088216e-05 ko04015 Rap1 signaling pathway 2/365 278/7206 0.000116877632952 ko04024 cAMP signaling pathway 2/365 279/7206 0.000118804002843 ko03018 RNA degradation 13/365 84/7206 0.000276021003542 ko04151 PI3K-Akt signaling pathway 6/365 390/7206 0.000318228039433 ko04217 Necroptosis 21/365 178/7206 0.00032545775721 ko03420 Nucleotide excision repair 9/365 46/7206 0.00041297681008 ko03410 Base excision repair 8/365 38/7206 0.000514237492503 ko04014 Ras signaling pathway 3/365 279/7206 0.00066056293695 ko03015 mRNA surveillance pathway 13/365 93/7206 0.000757706276989 ko04510 Focal adhesion 2/365 240/7206 0.000760487289152 ko03460 Fanconi anemia pathway 9/365 51/7206 0.00091164657892 ko04060 Cytokine-cytokine receptor interaction 1/365 191/7206 0.00111638983549 ko04371 Apelin signaling pathway 1/365 177/7206 0.00155370509479 ko04010 MAPK signaling pathway 5/365 321/7206 0.00155648174319 ko04932 Non-alcoholic fatty liver disease (NAFLD) 1/365 182/7206 0.00160204043018 ko05205 Proteoglycans in cancer 4/365 271/7206 0.00278474931433 ko04062 Chemokine signaling pathway 2/365 201/7206 0.0030294338586 ko04071 Sphingolipid signaling pathway 1/365 162/7206 0.00330726930781 ko04611 Platelet activation 1/365 163/7206 0.00331405431447 ko04360 Axon guidance 3/365 233/7206 0.00355342096357 ko05167 Kaposi's sarcoma-associated herpesvirus infection 2/365 191/7206 0.00640000012841 ko05160 Hepatitis C 1/365 153/7206 0.00750100446157 ko04210 Apoptosis 2/365 180/7206 0.00881681904707 ko04141 Protein processing in endoplasmic reticulum 2/365 184/7206 0.00921366514736 ko04630 Jak-STAT signaling pathway 1/365 132/7206 0.0147760242644 ko04933 AGE-RAGE signaling pathway in diabetic complications 1/365 135/7206 0.0151818090516 ko04931 Insulin resistance 1/365 137/7206 0.0156562519187 ko04114 Oocyte meiosis 14/365 139/7206 0.01629650424 ko04152 AMPK signaling pathway 2/365 161/7206 0.0174596632155 ko04722 Neurotrophin signaling pathway 2/365 160/7206 0.0174745702072 ko04145 Phagosome 2/365 162/7206 0.0174819538446 ko04140 Autophagy - animal 2/365 164/7206 0.017638292422 ko04530 Tight junction 4/365 228/7206 0.0196762584894 ko04912 GnRH signaling pathway 1/365 122/7206 0.0212581720492 ko03022 Basal transcription factors 6/365 44/7206 0.0224358402213 ko05200 Pathways in cancer 15/365 492/7206 0.0328190299846 ko04142 Lysosome 2/365 151/7206 0.0358533905204 ko04670 Leukocyte transendothelial migration 2/365 151/7206 0.0358533905204 ko04914 Progesterone-mediated oocyte maturation 10/365 104/7206 0.0415487666086 ko04659 Th17 cell differentiation 1/365 106/7206 0.0441254077859 ko04012 ErbB signaling pathway 1/365 109/7206 0.0445614890737 ko04070 Phosphatidylinositol signaling system 1/365 112/7206 0.0459363392232 ko05164 Influenza A 3/365 167/7206 0.0485920911038 ko04910 Insulin signaling pathway 3/365 172/7206 0.0498239616054