ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 39/396 191/7206 3.90968001115e-13 ko04380 Osteoclast differentiation 24/396 134/7206 2.14962870815e-07 ko04621 NOD-like receptor signaling pathway 26/396 157/7206 3.35774600262e-07 ko05164 Influenza A 26/396 167/7206 1.1516595869e-06 ko05321 Inflammatory bowel disease (IBD) 14/396 56/7206 1.26860459206e-06 ko04064 NF-kappa B signaling pathway 18/396 96/7206 3.68359026646e-06 ko04650 Natural killer cell mediated cytotoxicity 18/396 97/7206 4.29842734585e-06 ko05140 Leishmaniasis 15/396 75/7206 1.05727694114e-05 ko04659 Th17 cell differentiation 18/396 106/7206 1.5629123519e-05 ko05340 Primary immunodeficiency 9/396 30/7206 2.12560380281e-05 ko05145 Toxoplasmosis 19/396 126/7206 5.12030584719e-05 ko04658 Th1 and Th2 cell differentiation 16/396 96/7206 5.86334252672e-05 ko05152 Tuberculosis 24/396 187/7206 0.000103815569732 ko04672 Intestinal immune network for IgA production 9/396 37/7206 0.000131096401568 ko05162 Measles 17/396 120/7206 0.000274747936432 ko04610 Complement and coagulation cascades 13/396 79/7206 0.000327375521844 ko04710 Circadian rhythm 9/396 43/7206 0.000443157227121 ko04217 Necroptosis 21/396 178/7206 0.00115066168434 ko04660 T cell receptor signaling pathway 16/396 124/7206 0.00117099761048 ko05330 Allograft rejection 6/396 24/7206 0.00153051178144 ko03013 RNA transport 1/396 166/7206 0.00154747054273 ko05161 Hepatitis B 20/396 173/7206 0.00179363555259 ko00590 Arachidonic acid metabolism 9/396 52/7206 0.00186540945493 ko05332 Graft-versus-host disease 5/396 18/7206 0.00230737769159 ko04611 Platelet activation 19/396 163/7206 0.00242052977002 ko05168 Herpes simplex infection 20/396 182/7206 0.00262482609756 ko05144 Malaria 8/396 45/7206 0.0027777683739 ko04662 B cell receptor signaling pathway 12/396 88/7206 0.00295966685402 ko05150 Staphylococcus aureus infection 7/396 36/7206 0.00299280414905 ko04620 Toll-like receptor signaling pathway 13/396 100/7206 0.00309697141501 ko05231 Choline metabolism in cancer 16/396 134/7206 0.00312813423397 ko05323 Rheumatoid arthritis 12/396 89/7206 0.00325594512875 ko04668 TNF signaling pathway 15/396 120/7206 0.00334479652246 ko04072 Phospholipase D signaling pathway 21/396 197/7206 0.00360820327254 ko00120 Primary bile acid biosynthesis 5/396 20/7206 0.00381240397275 ko05320 Autoimmune thyroid disease 6/396 29/7206 0.00427935314335 ko05230 Central carbon metabolism in cancer 11/396 81/7206 0.0045030868051 ko03040 Spliceosome 1/396 145/7206 0.00483817427158 ko04670 Leukocyte transendothelial migration 17/396 151/7206 0.00547344468034 ko04630 Jak-STAT signaling pathway 15/396 132/7206 0.00622347983175 ko00051 Fructose and mannose metabolism 7/396 42/7206 0.00728639245493 ko04657 IL-17 signaling pathway 11/396 87/7206 0.00775264130755 ko05133 Pertussis 11/396 87/7206 0.00775264130755 ko04666 Fc gamma R-mediated phagocytosis 14/396 122/7206 0.00777192324003 ko04640 Hematopoietic cell lineage 9/396 64/7206 0.00781552074598 ko04612 Antigen processing and presentation 10/396 77/7206 0.00906420487561 ko04664 Fc epsilon RI signaling pathway 10/396 77/7206 0.00906420487561 ko05215 Prostate cancer 13/396 111/7206 0.00937750041858 ko04070 Phosphatidylinositol signaling system 13/396 112/7206 0.00985951169367 ko03010 Ribosome 1/396 129/7206 0.0100936334993 ko04062 Chemokine signaling pathway 20/396 201/7206 0.010685109662 ko04933 AGE-RAGE signaling pathway in diabetic complications 15/396 135/7206 0.0110534894472 ko05160 Hepatitis C 16/396 153/7206 0.0112428037814 ko05310 Asthma 4/396 17/7206 0.0120739528893 ko00360 Phenylalanine metabolism 4/396 17/7206 0.0120739528893 ko04390 Hippo signaling pathway 3/396 188/7206 0.0136626024805 ko05167 Kaposi's sarcoma-associated herpesvirus infection 19/396 191/7206 0.0141775476425 ko00950 Isoquinoline alkaloid biosynthesis 3/396 10/7206 0.0147955887079 ko00592 alpha-Linolenic acid metabolism 4/396 19/7206 0.0180303292533 ko04145 Phagosome 16/396 162/7206 0.0214633749731 ko00564 Glycerophospholipid metabolism 11/396 99/7206 0.0230107739612 ko05146 Amoebiasis 11/396 99/7206 0.0230107739612 ko00140 Steroid hormone biosynthesis 6/396 41/7206 0.023296302215 ko04960 Aldosterone-regulated sodium reabsorption 6/396 41/7206 0.023296302215 ko04066 HIF-1 signaling pathway 13/396 123/7206 0.0246143181906 ko05166 HTLV-I infection 25/396 292/7206 0.0250657577454 ko00565 Ether lipid metabolism 6/396 42/7206 0.0259646205082 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/396 5/7206 0.026964996159 ko04940 Type I diabetes mellitus 5/396 32/7206 0.028868509668 ko04210 Apoptosis 17/396 180/7206 0.0290334170785 ko05142 Chagas disease (American trypanosomiasis) 13/396 130/7206 0.0311589373798 ko04514 Cell adhesion molecules (CAMs) 13/396 130/7206 0.0311589373798 ko00350 Tyrosine metabolism 5/396 33/7206 0.0325432477916 ko04512 ECM-receptor interaction 9/396 79/7206 0.039691294136 ko05034 Alcoholism 6/396 238/7206 0.0414114362737