ko pathway ratio_in_study ratio_in_pop p_value ko05322 Systemic lupus erythematosus 75/392 151/7206 6.68090421699e-56 ko05034 Alcoholism 74/392 238/7206 9.39303767274e-38 ko05203 Viral carcinogenesis 60/392 277/7206 2.16351108819e-21 ko03040 Spliceosome 42/392 145/7206 3.31241170847e-20 ko04110 Cell cycle 39/392 145/7206 1.38809622074e-17 ko04111 Cell cycle - yeast 28/392 90/7206 1.06100161591e-14 ko03030 DNA replication 16/392 38/7206 3.21491594954e-11 ko03013 RNA transport 32/392 166/7206 2.08793269442e-10 ko03008 Ribosome biogenesis in eukaryotes 21/392 79/7206 6.63213994797e-10 ko04113 Meiosis - yeast 19/392 70/7206 2.99989836578e-09 ko03440 Homologous recombination 14/392 41/7206 1.4451229997e-08 ko03460 Fanconi anemia pathway 14/392 51/7206 3.21218237467e-07 ko03430 Mismatch repair 9/392 22/7206 1.00606394406e-06 ko04024 cAMP signaling pathway 1/392 279/7206 4.69111636496e-06 ko04144 Endocytosis 3/392 342/7206 1.22563682683e-05 ko03410 Base excision repair 10/392 38/7206 2.42223911729e-05 ko03018 RNA degradation 15/392 84/7206 3.87387592106e-05 ko04022 cGMP-PKG signaling pathway 1/392 216/7206 0.000104190082391 ko03420 Nucleotide excision repair 10/392 46/7206 0.000141241631701 ko04114 Oocyte meiosis 19/392 139/7206 0.000172284725596 ko04014 Ras signaling pathway 3/392 279/7206 0.000217273400995 ko05010 Alzheimer's disease 1/392 202/7206 0.000226043754857 ko05202 Transcriptional misregulation in cancer 23/392 188/7206 0.000227389315543 ko04261 Adrenergic signaling in cardiomyocytes 1/392 205/7206 0.00023046295203 ko04510 Focal adhesion 2/392 240/7206 0.00023504375645 ko00240 Pyrimidine metabolism 16/392 110/7206 0.000271607429202 ko05205 Proteoglycans in cancer 3/392 271/7206 0.000309414469665 ko04151 PI3K-Akt signaling pathway 7/392 390/7206 0.000332649909125 ko04072 Phospholipase D signaling pathway 1/392 197/7206 0.000336205141757 ko04810 Regulation of actin cytoskeleton 3/392 264/7206 0.000442801298411 ko05152 Tuberculosis 1/392 187/7206 0.000488348546067 ko04010 MAPK signaling pathway 5/392 321/7206 0.000576849228637 ko04217 Necroptosis 21/392 178/7206 0.000667385925061 ko04728 Dopaminergic synapse 1/392 185/7206 0.000751204340867 ko04015 Rap1 signaling pathway 4/392 278/7206 0.00103025293082 ko04360 Axon guidance 3/392 233/7206 0.00178315323141 ko04062 Chemokine signaling pathway 2/392 201/7206 0.00221647588615 ko04670 Leukocyte transendothelial migration 1/392 151/7206 0.00327213386908 ko04621 NOD-like receptor signaling pathway 1/392 157/7206 0.00350584021206 ko04914 Progesterone-mediated oocyte maturation 13/392 104/7206 0.00400889428706 ko04210 Apoptosis 2/392 180/7206 0.00428332448772 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/392 182/7206 0.0043083256191 ko03015 mRNA surveillance pathway 12/392 93/7206 0.00432453579932 ko04371 Apelin signaling pathway 2/392 177/7206 0.00627286299815 ko04530 Tight junction 4/392 228/7206 0.00733558912845 ko04540 Gap junction 1/392 128/7206 0.0100658931336 ko05142 Chagas disease (American trypanosomiasis) 1/392 130/7206 0.0100921911516 ko04514 Cell adhesion molecules (CAMs) 1/392 130/7206 0.0100921911516 ko04630 Jak-STAT signaling pathway 1/392 132/7206 0.010250768358 ko04933 AGE-RAGE signaling pathway in diabetic complications 1/392 135/7206 0.0107409042258 ko05166 HTLV-I infection 26/392 292/7206 0.0117817763735 ko04722 Neurotrophin signaling pathway 2/392 160/7206 0.0123757524113 ko04071 Sphingolipid signaling pathway 2/392 162/7206 0.0126045404163 ko04140 Autophagy - animal 2/392 164/7206 0.0129622341361 ko05167 Kaposi's sarcoma-associated herpesvirus infection 3/392 191/7206 0.0138301965896 ko04912 GnRH signaling pathway 1/392 122/7206 0.0145928097607 ko00190 Oxidative phosphorylation 1/392 127/7206 0.0153595003329 ko04142 Lysosome 2/392 151/7206 0.0173583357842 ko05160 Hepatitis C 2/392 153/7206 0.0175446308983 ko04141 Protein processing in endoplasmic reticulum 3/392 184/7206 0.0192874499542 ko04911 Insulin secretion 1/392 117/7206 0.0214204548255 ko05418 Fluid shear stress and atherosclerosis 3/392 173/7206 0.0258439574862 ko04659 Th17 cell differentiation 1/392 106/7206 0.0304342289281 ko03022 Basal transcription factors 6/392 44/7206 0.0305455970098 ko04972 Pancreatic secretion 1/392 111/7206 0.0314066996197 ko04380 Osteoclast differentiation 2/392 134/7206 0.0342622755382 ko05231 Choline metabolism in cancer 2/392 134/7206 0.0342622755382 ko05164 Influenza A 3/392 167/7206 0.0359468183789 ko00564 Glycerophospholipid metabolism 1/392 99/7206 0.043823900857 ko04620 Toll-like receptor signaling pathway 1/392 100/7206 0.0439076093013 ko05016 Huntington's disease 5/392 215/7206 0.0450523767333 ko04925 Aldosterone synthesis and secretion 1/392 105/7206 0.0461302132752