ko pathway ratio_in_study ratio_in_pop p_value ko05322 Systemic lupus erythematosus 74/349 151/7206 1.542353518e-58 ko05034 Alcoholism 74/349 238/7206 1.81476759107e-41 ko05203 Viral carcinogenesis 59/349 277/7206 2.67746416022e-23 ko03040 Spliceosome 42/349 145/7206 3.54285489887e-22 ko04110 Cell cycle 32/349 145/7206 1.96887807668e-13 ko04111 Cell cycle - yeast 23/349 90/7206 2.25401923819e-11 ko03013 RNA transport 27/349 166/7206 2.10986162471e-08 ko03008 Ribosome biogenesis in eukaryotes 18/349 79/7206 2.54862481095e-08 ko03030 DNA replication 12/349 38/7206 1.19376513574e-07 ko04113 Meiosis - yeast 15/349 70/7206 8.86207075291e-07 ko04144 Endocytosis 1/349 342/7206 9.20303783389e-07 ko03440 Homologous recombination 10/349 41/7206 1.82103904577e-05 ko05202 Transcriptional misregulation in cancer 23/349 188/7206 3.4650926291e-05 ko04020 Calcium signaling pathway 1/349 265/7206 5.12483812235e-05 ko03430 Mismatch repair 7/349 22/7206 5.33715049742e-05 ko03410 Base excision repair 9/349 38/7206 6.17961798767e-05 ko00240 Pyrimidine metabolism 16/349 110/7206 7.03161654128e-05 ko04217 Necroptosis 21/349 178/7206 0.000128806678926 ko03420 Nucleotide excision repair 9/349 46/7206 0.000296316117031 ko04022 cGMP-PKG signaling pathway 1/349 216/7206 0.000522576713697 ko04024 cAMP signaling pathway 3/349 279/7206 0.000901580461334 ko04114 Oocyte meiosis 16/349 139/7206 0.00105889468716 ko05166 HTLV-I infection 27/349 292/7206 0.00114098303425 ko05152 Tuberculosis 1/349 187/7206 0.00156620983719 ko03018 RNA degradation 11/349 84/7206 0.00227232130825 ko04932 Non-alcoholic fatty liver disease (NAFLD) 1/349 182/7206 0.00234901902515 ko04914 Progesterone-mediated oocyte maturation 12/349 104/7206 0.00426968242481 ko05010 Alzheimer's disease 2/349 202/7206 0.00434214166898 ko04261 Adrenergic signaling in cardiomyocytes 2/349 205/7206 0.00438248756872 ko04921 Oxytocin signaling pathway 2/349 209/7206 0.0045759055012 ko04072 Phospholipase D signaling pathway 2/349 197/7206 0.00625335366864 ko04270 Vascular smooth muscle contraction 1/349 154/7206 0.00705210538654 ko05012 Parkinson's disease 1/349 155/7206 0.00708568322601 ko04621 NOD-like receptor signaling pathway 1/349 157/7206 0.00720959197748 ko04725 Cholinergic synapse 1/349 160/7206 0.0075399320441 ko04728 Dopaminergic synapse 2/349 185/7206 0.00877302239114 ko04014 Ras signaling pathway 5/349 279/7206 0.0101887973901 ko03460 Fanconi anemia pathway 7/349 51/7206 0.0108334872651 ko04371 Apelin signaling pathway 2/349 177/7206 0.0124196729715 ko05016 Huntington's disease 3/349 215/7206 0.014038620839 ko04015 Rap1 signaling pathway 5/349 278/7206 0.0142463079773 ko04151 PI3K-Akt signaling pathway 9/349 390/7206 0.0145649513876 ko04726 Serotonergic synapse 1/349 137/7206 0.014793513425 ko03022 Basal transcription factors 6/349 44/7206 0.0184014501785 ko05168 Herpes simplex infection 16/349 182/7206 0.0207786188672 ko00190 Oxidative phosphorylation 1/349 127/7206 0.0213695137809 ko05142 Chagas disease (American trypanosomiasis) 1/349 130/7206 0.0214831316316 ko04915 Estrogen signaling pathway 1/349 131/7206 0.0216231928292 ko04630 Jak-STAT signaling pathway 1/349 132/7206 0.0218144636637 ko04380 Osteoclast differentiation 1/349 134/7206 0.0223511820184 ko04010 MAPK signaling pathway 7/349 321/7206 0.022546610484 ko04611 Platelet activation 2/349 163/7206 0.0249111001852 ko04115 p53 signaling pathway 8/349 74/7206 0.0259519870169 ko04142 Lysosome 2/349 151/7206 0.0345988607422 ko05160 Hepatitis C 2/349 153/7206 0.0346987488624 ko04141 Protein processing in endoplasmic reticulum 3/349 184/7206 0.035642903436 ko04712 Circadian rhythm - plant 2/349 7/7206 0.0417838514993 ko04070 Phosphatidylinositol signaling system 1/349 112/7206 0.0443462198971 ko04510 Focal adhesion 5/349 240/7206 0.0449505015869 ko03015 mRNA surveillance pathway 9/349 93/7206 0.0450650003085