ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	212/1299	423/7206	9.37776513928e-55
ko04724	Glutamatergic synapse	93/1299	152/7206	6.08121268795e-33
ko05033	Nicotine addiction	50/1299	56/7206	3.00076574672e-31
ko05032	Morphine addiction	74/1299	110/7206	2.41290873402e-30
ko04713	Circadian entrainment	82/1299	136/7206	1.68308340496e-28
ko04727	GABAergic synapse	71/1299	110/7206	1.90159325815e-27
ko04725	Cholinergic synapse	81/1299	160/7206	2.53085745501e-21
ko04721	Synaptic vesicle cycle	52/1299	80/7206	1.31705834982e-20
ko04728	Dopaminergic synapse	87/1299	185/7206	4.3575240568e-20
ko04024	cAMP signaling pathway	113/1299	279/7206	4.25201870756e-19
ko04723	Retrograde endocannabinoid signaling	81/1299	175/7206	3.01758130448e-18
ko04020	Calcium signaling pathway	105/1299	265/7206	3.50517097854e-17
ko04911	Insulin secretion	59/1299	117/7206	9.65282997918e-16
ko04726	Serotonergic synapse	65/1299	137/7206	1.57608075879e-15
ko04744	Phototransduction	28/1299	36/7206	7.77878738315e-15
ko04742	Taste transduction	37/1299	61/7206	1.2562706493e-13
ko05031	Amphetamine addiction	45/1299	91/7206	6.27504222636e-12
ko04921	Oxytocin signaling pathway	79/1299	209/7206	6.81673792521e-12
ko04261	Adrenergic signaling in cardiomyocytes	77/1299	205/7206	1.77731045461e-11
ko04970	Salivary secretion	44/1299	95/7206	1.70552450816e-10
ko03040	Spliceosome	2/1299	145/7206	2.22226858867e-10
ko04720	Long-term potentiation	45/1299	99/7206	2.29413772682e-10
ko03010	Ribosome	1/1299	129/7206	3.44146253833e-10
ko04925	Aldosterone synthesis and secretion	44/1299	105/7206	9.05827095576e-09
ko04740	Olfactory transduction	36/1299	80/7206	2.03749376757e-08
ko05322	Systemic lupus erythematosus	5/1299	151/7206	4.36418364131e-08
ko05030	Cocaine addiction	33/1299	73/7206	6.92051538716e-08
ko03013	RNA transport	7/1299	166/7206	1.09652007271e-07
ko05203	Viral carcinogenesis	20/1299	277/7206	2.43786223774e-07
ko04971	Gastric acid secretion	38/1299	98/7206	1.00519816562e-06
ko04070	Phosphatidylinositol signaling system	42/1299	112/7206	1.24603656863e-06
ko04360	Axon guidance	71/1299	233/7206	2.34962835363e-06
ko05168	Herpes simplex infection	11/1299	182/7206	3.19803321572e-06
ko04060	Cytokine-cytokine receptor interaction	12/1299	191/7206	3.37932590012e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1299	74/7206	4.86954261876e-06
ko04022	cGMP-PKG signaling pathway	66/1299	216/7206	5.47662760195e-06
ko04966	Collecting duct acid secretion	15/1299	26/7206	6.69919842623e-06
ko04141	Protein processing in endoplasmic reticulum	12/1299	184/7206	9.28789716361e-06
ko05164	Influenza A	11/1299	167/7206	2.39496320706e-05
ko04745	Phototransduction - fly	18/1299	38/7206	3.10866224908e-05
ko04072	Phospholipase D signaling pathway	59/1299	197/7206	3.11403374661e-05
ko04621	NOD-like receptor signaling pathway	10/1299	157/7206	3.32292167356e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1299	79/7206	4.45505470131e-05
ko04110	Cell cycle	9/1299	145/7206	4.45625470682e-05
ko04972	Pancreatic secretion	38/1299	111/7206	4.80406773158e-05
ko04750	Inflammatory mediator regulation of TRP channels	40/1299	122/7206	7.02201643773e-05
ko04730	Long-term depression	29/1299	78/7206	7.35399613989e-05
ko05414	Dilated cardiomyopathy	37/1299	112/7206	0.000103026886309
ko04540	Gap junction	41/1299	128/7206	0.000105588857204
ko04014	Ras signaling pathway	75/1299	279/7206	0.000176711745168
ko05110	Vibrio cholerae infection	24/1299	63/7206	0.000181482290098
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1299	79/7206	0.000184266883422
ko04514	Cell adhesion molecules (CAMs)	41/1299	130/7206	0.000185285238476
ko04710	Circadian rhythm	18/1299	43/7206	0.000226260640007
ko04923	Regulation of lipolysis in adipocytes	27/1299	77/7206	0.000289748215968
ko00520	Amino sugar and nucleotide sugar metabolism	1/1299	55/7206	0.00033143960734
ko04010	MAPK signaling pathway	83/1299	321/7206	0.000344358074623
ko05140	Leishmaniasis	3/1299	75/7206	0.000431958588049
ko04120	Ubiquitin mediated proteolysis	10/1299	138/7206	0.000454165993781
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1299	59/7206	0.000458479077127
ko04924	Renin secretion	29/1299	86/7206	0.000551583079479
ko04976	Bile secretion	27/1299	80/7206	0.000638194804185
ko04915	Estrogen signaling pathway	39/1299	131/7206	0.000822912567198
ko05205	Proteoglycans in cancer	29/1299	271/7206	0.000917710659516
ko05169	Epstein-Barr virus infection	20/1299	206/7206	0.0011955806209
ko03420	Nucleotide excision repair	1/1299	46/7206	0.00176683390951
ko00562	Inositol phosphate metabolism	28/1299	89/7206	0.00198565653311
ko04626	Plant-pathogen interaction	9/1299	18/7206	0.0019879646964
ko04930	Type II diabetes mellitus	19/1299	54/7206	0.00221259085944
ko03022	Basal transcription factors	1/1299	44/7206	0.00267474341562
ko05144	Malaria	1/1299	45/7206	0.0027481280826
ko05166	HTLV-I infection	34/1299	292/7206	0.00305830497835
ko04711	Circadian rhythm - fly	7/1299	13/7206	0.00378968719922
ko05162	Measles	10/1299	120/7206	0.00379987933702
ko04622	RIG-I-like receptor signaling pathway	3/1299	62/7206	0.00417348073567
ko04658	Th1 and Th2 cell differentiation	7/1299	96/7206	0.00453914464776
ko04064	NF-kappa B signaling pathway	7/1299	96/7206	0.00453914464776
ko05133	Pertussis	6/1299	87/7206	0.00458991014903
ko04610	Complement and coagulation cascades	5/1299	79/7206	0.00463937681605
ko04260	Cardiac muscle contraction	29/1299	98/7206	0.00499377226895
ko03018	RNA degradation	6/1299	84/7206	0.00632109407422
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1299	14/7206	0.00641113485351
ko04612	Antigen processing and presentation	5/1299	77/7206	0.00657230203295
ko05321	Inflammatory bowel disease (IBD)	3/1299	56/7206	0.00859537075354
ko05131	Shigellosis	6/1299	82/7206	0.00874324417674
ko00630	Glyoxylate and dicarboxylate metabolism	1/1299	38/7206	0.00944170471879
ko05145	Toxoplasmosis	12/1299	126/7206	0.0098876902006
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1299	182/7206	0.0108835448318
ko04657	IL-17 signaling pathway	7/1299	87/7206	0.0113461847368
ko04146	Peroxisome	7/1299	89/7206	0.0116406843855
ko05231	Choline metabolism in cancer	36/1299	134/7206	0.0119873737254
ko05161	Hepatitis B	19/1299	173/7206	0.0122830615738
ko00280	Valine, leucine and isoleucine degradation	3/1299	54/7206	0.0122945636006
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1299	100/7206	0.0124281781895
ko00480	Glutathione metabolism	3/1299	55/7206	0.0124620590945
ko04214	Apoptosis - fly	5/1299	72/7206	0.0126577021961
ko00500	Starch and sucrose metabolism	1/1299	35/7206	0.0139448416365
ko04270	Vascular smooth muscle contraction	40/1299	154/7206	0.0142650082526
ko03320	PPAR signaling pathway	5/1299	69/7206	0.0172983965365
ko00071	Fatty acid degradation	2/1299	45/7206	0.0173653997273
ko05016	Huntington's disease	26/1299	215/7206	0.0192338459566
ko00860	Porphyrin and chlorophyll metabolism	1/1299	34/7206	0.0220999103612
ko04371	Apelin signaling pathway	44/1299	177/7206	0.0222593733757
ko04115	p53 signaling pathway	6/1299	74/7206	0.0223110263329
ko04918	Thyroid hormone synthesis	24/1299	86/7206	0.0229905368588
ko04912	GnRH signaling pathway	32/1299	122/7206	0.0233286749525
ko00140	Steroid hormone biosynthesis	2/1299	41/7206	0.0240316158071
ko00240	Pyrimidine metabolism	11/1299	110/7206	0.0244183829802
ko04922	Glucagon signaling pathway	33/1299	128/7206	0.0269377849084
ko04350	TGF-beta signaling pathway	10/1299	103/7206	0.02737485309
ko04964	Proximal tubule bicarbonate reclamation	10/1299	29/7206	0.0286497658213
ko04217	Necroptosis	21/1299	178/7206	0.0293979899038
ko00600	Sphingolipid metabolism	5/1299	63/7206	0.0325593195836
ko05012	Parkinson's disease	18/1299	155/7206	0.0345424175254
ko03410	Base excision repair	2/1299	38/7206	0.034969352287
ko05219	Bladder cancer	3/1299	48/7206	0.0360180314
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1299	40/7206	0.036083583731
ko04960	Aldosterone-regulated sodium reabsorption	13/1299	41/7206	0.0381978369974
ko03015	mRNA surveillance pathway	9/1299	93/7206	0.0403682997699
ko04113	Meiosis - yeast	6/1299	70/7206	0.0410028567052
ko00330	Arginine and proline metabolism	5/1299	61/7206	0.0443620643057
ko05132	Salmonella infection	10/1299	98/7206	0.0462226854951
ko04213	Longevity regulating pathway - multiple species	23/1299	86/7206	0.0466717294724
ko04071	Sphingolipid signaling pathway	39/1299	162/7206	0.0491147262974