ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 23/280 80/7206 1.37619475746e-14 ko04728 Dopaminergic synapse 27/280 185/7206 1.97853961569e-09 ko04966 Collecting duct acid secretion 9/280 26/7206 3.10223016175e-07 ko04724 Glutamatergic synapse 21/280 152/7206 3.47146198235e-07 ko05120 Epithelial cell signaling in Helicobacter pylori infection 15/280 92/7206 2.11024460461e-06 ko04911 Insulin secretion 17/280 117/7206 2.31275966605e-06 ko04727 GABAergic synapse 16/280 110/7206 4.54896157337e-06 ko05032 Morphine addiction 16/280 110/7206 4.54896157337e-06 ko04713 Circadian entrainment 18/280 136/7206 4.58029166917e-06 ko04723 Retrograde endocannabinoid signaling 20/280 175/7206 1.30785032156e-05 ko04261 Adrenergic signaling in cardiomyocytes 22/280 205/7206 1.32910843083e-05 ko05110 Vibrio cholerae infection 11/280 63/7206 2.5459567454e-05 ko05031 Amphetamine addiction 13/280 91/7206 4.39565128374e-05 ko05033 Nicotine addiction 10/280 56/7206 4.8755222751e-05 ko04726 Serotonergic synapse 16/280 137/7206 7.48251285053e-05 ko04024 cAMP signaling pathway 25/280 279/7206 8.82002527563e-05 ko04114 Oocyte meiosis 15/280 139/7206 0.000303605414714 ko04360 Axon guidance 21/280 233/7206 0.000348629724754 ko04971 Gastric acid secretion 12/280 98/7206 0.000382918267719 ko04961 Endocrine and other factor-regulated calcium reabsorption 9/280 59/7206 0.000404011036918 ko04720 Long-term potentiation 12/280 99/7206 0.000420926237423 ko04725 Cholinergic synapse 16/280 160/7206 0.0004588351791 ko04626 Plant-pathogen interaction 5/280 18/7206 0.000482561765447 ko04745 Phototransduction - fly 7/280 38/7206 0.000555412221733 ko04964 Proximal tubule bicarbonate reclamation 6/280 29/7206 0.000727788459522 ko04970 Salivary secretion 11/280 95/7206 0.0010715804527 ko00190 Oxidative phosphorylation 13/280 127/7206 0.00124934166301 ko04145 Phagosome 15/280 162/7206 0.00151850232519 ko05323 Rheumatoid arthritis 10/280 89/7206 0.00225142487351 ko04744 Phototransduction 6/280 36/7206 0.00237540304094 ko04921 Oxytocin signaling pathway 17/280 209/7206 0.00329298336451 ko04960 Aldosterone-regulated sodium reabsorption 6/280 41/7206 0.00466223542685 ko04973 Carbohydrate digestion and absorption 6/280 42/7206 0.00526600479266 ko05152 Tuberculosis 15/280 187/7206 0.00655953177835 ko04016 MAPK signaling pathway - plant 4/280 20/7206 0.00660471325121 ko04940 Type I diabetes mellitus 5/280 32/7206 0.00726941120118 ko04750 Inflammatory mediator regulation of TRP channels 11/280 122/7206 0.00764970498154 ko04391 Hippo signaling pathway - fly 9/280 90/7206 0.00796880602024 ko04972 Pancreatic secretion 10/280 111/7206 0.0108246332837 ko04022 cGMP-PKG signaling pathway 16/280 216/7206 0.0114335159103 ko04260 Cardiac muscle contraction 9/280 98/7206 0.0135823620697 ko00604 Glycosphingolipid biosynthesis - ganglio series 3/280 14/7206 0.0153656335066 ko04014 Ras signaling pathway 19/280 279/7206 0.0164244329792 ko04142 Lysosome 12/280 151/7206 0.0166508161194 ko04924 Renin secretion 8/280 86/7206 0.0181327534463 ko04978 Mineral absorption 5/280 40/7206 0.0184747649384 ko02024 Quorum sensing 3/280 15/7206 0.0186648895433 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 3/280 15/7206 0.0186648895433 ko04925 Aldosterone synthesis and secretion 9/280 105/7206 0.0205335938118 ko05014 Amyotrophic lateral sclerosis (ALS) 7/280 74/7206 0.0242470808907 ko00512 Mucin type O-glycan biosynthesis 4/280 29/7206 0.0246458117545 ko04742 Taste transduction 6/280 61/7206 0.0302874605141 ko05322 Systemic lupus erythematosus 1/280 151/7206 0.0313804711967 ko04922 Glucagon signaling pathway 10/280 128/7206 0.0328766319493 ko04722 Neurotrophin signaling pathway 12/280 160/7206 0.0341126346553 ko04060 Cytokine-cytokine receptor interaction 2/280 191/7206 0.0351447887633 ko04976 Bile secretion 7/280 80/7206 0.0352392947804 ko04740 Olfactory transduction 7/280 80/7206 0.0352392947804 ko04080 Neuroactive ligand-receptor interaction 25/280 423/7206 0.0365695546696 ko04010 MAPK signaling pathway 20/280 321/7206 0.0367284192821 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/280 1/7206 0.0388565084651 ko04144 Endocytosis 21/280 342/7206 0.0427006114859 ko03040 Spliceosome 1/280 145/7206 0.0463077730204