ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 74/381 145/7206 3.13294624562e-57 ko03030 DNA replication 21/381 38/7206 1.13220701108e-17 ko04110 Cell cycle 38/381 145/7206 3.66237653043e-17 ko03008 Ribosome biogenesis in eukaryotes 24/381 79/7206 8.68366763588e-13 ko04111 Cell cycle - yeast 25/381 90/7206 2.71087125732e-12 ko03013 RNA transport 34/381 166/7206 4.20676934e-12 ko03410 Base excision repair 13/381 38/7206 3.33315272571e-08 ko03015 mRNA surveillance pathway 20/381 93/7206 5.34498023991e-08 ko03420 Nucleotide excision repair 14/381 46/7206 5.35447655089e-08 ko04113 Meiosis - yeast 17/381 70/7206 8.23223616398e-08 ko00240 Pyrimidine metabolism 19/381 110/7206 3.99843555152e-06 ko03430 Mismatch repair 8/381 22/7206 9.42926750903e-06 ko04144 Endocytosis 3/381 342/7206 1.71900443958e-05 ko03460 Fanconi anemia pathway 10/381 51/7206 0.000275868385232 ko05168 Herpes simplex infection 21/381 182/7206 0.000624110713524 ko04060 Cytokine-cytokine receptor interaction 1/381 191/7206 0.000765042609345 ko04010 MAPK signaling pathway 5/381 321/7206 0.000799783571819 ko04371 Apelin signaling pathway 1/381 177/7206 0.00105537998684 ko04932 Non-alcoholic fatty liver disease (NAFLD) 1/381 182/7206 0.00109023750502 ko04120 Ubiquitin mediated proteolysis 17/381 138/7206 0.00143113972035 ko04024 cAMP signaling pathway 4/381 279/7206 0.00145433570672 ko04151 PI3K-Akt signaling pathway 8/381 390/7206 0.00157294224987 ko04723 Retrograde endocannabinoid signaling 1/381 175/7206 0.00160722216994 ko05166 HTLV-I infection 28/381 292/7206 0.00192444176708 ko04062 Chemokine signaling pathway 2/381 201/7206 0.00210726247338 ko04071 Sphingolipid signaling pathway 1/381 162/7206 0.00225467975496 ko04810 Regulation of actin cytoskeleton 4/381 264/7206 0.00284050916973 ko04114 Oocyte meiosis 16/381 139/7206 0.00310573401864 ko04725 Cholinergic synapse 1/381 160/7206 0.00342301000742 ko03020 RNA polymerase 6/381 29/7206 0.00353464241404 ko04712 Circadian rhythm - plant 3/381 7/7206 0.00437563196597 ko03018 RNA degradation 11/381 84/7206 0.00446416726894 ko05160 Hepatitis C 1/381 153/7206 0.00502686069077 ko03440 Homologous recombination 7/381 41/7206 0.0051629361068 ko04015 Rap1 signaling pathway 5/381 278/7206 0.00563610741972 ko04014 Ras signaling pathway 5/381 279/7206 0.00569818512475 ko03060 Protein export 5/381 23/7206 0.00614172462298 ko04921 Oxytocin signaling pathway 3/381 209/7206 0.00697661109278 ko04218 Cellular senescence 18/381 177/7206 0.00928230016826 ko04530 Tight junction 4/381 228/7206 0.0101017292579 ko04713 Circadian entrainment 1/381 136/7206 0.0103127827577 ko04914 Progesterone-mediated oocyte maturation 12/381 104/7206 0.0118476934621 ko04139 Mitophagy - yeast 6/381 37/7206 0.0121210586777 ko04072 Phospholipase D signaling pathway 3/381 197/7206 0.0139472194693 ko01200 Carbon metabolism 1/381 128/7206 0.0148714455687 ko04540 Gap junction 1/381 128/7206 0.0148714455687 ko05142 Chagas disease (American trypanosomiasis) 1/381 130/7206 0.0152501793884 ko04915 Estrogen signaling pathway 1/381 131/7206 0.0155063609554 ko04270 Vascular smooth muscle contraction 2/381 154/7206 0.0173840126228 ko04621 NOD-like receptor signaling pathway 2/381 157/7206 0.0175483082179 ko04722 Neurotrophin signaling pathway 2/381 160/7206 0.018078792794 ko04022 cGMP-PKG signaling pathway 4/381 216/7206 0.0191858702094 ko04912 GnRH signaling pathway 1/381 122/7206 0.0219030531191 ko04360 Axon guidance 5/381 233/7206 0.0248783042928 ko04261 Adrenergic signaling in cardiomyocytes 4/381 205/7206 0.0257126569506 ko05217 Basal cell carcinoma 8/381 68/7206 0.02613527771 ko03022 Basal transcription factors 6/381 44/7206 0.0270373625853 ko04012 ErbB signaling pathway 1/381 109/7206 0.0305315619636 ko05032 Morphine addiction 1/381 110/7206 0.0305426799948 ko04972 Pancreatic secretion 1/381 111/7206 0.0306375432519 ko04070 Phosphatidylinositol signaling system 1/381 112/7206 0.0308160085256 ko05169 Epstein-Barr virus infection 18/381 206/7206 0.0376173020454 ko04925 Aldosterone synthesis and secretion 1/381 105/7206 0.0445840999098 ko01521 EGFR tyrosine kinase inhibitor resistance 1/381 106/7206 0.0450214765942 ko05152 Tuberculosis 4/381 187/7206 0.0468603011949 ko04380 Osteoclast differentiation 2/381 134/7206 0.0485708568433 ko04933 AGE-RAGE signaling pathway in diabetic complications 2/381 135/7206 0.0489412918162