ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	149/902	423/7206	5.9674307886e-36
ko05033	Nicotine addiction	46/902	56/7206	1.12732068979e-32
ko04724	Glutamatergic synapse	76/902	152/7206	5.14922084829e-30
ko04727	GABAergic synapse	57/902	110/7206	9.59841064256e-24
ko05032	Morphine addiction	56/902	110/7206	7.52614387e-23
ko04728	Dopaminergic synapse	73/902	185/7206	4.82965475817e-21
ko04744	Phototransduction	28/902	36/7206	4.12731401377e-19
ko04723	Retrograde endocannabinoid signaling	67/902	175/7206	1.46084899749e-18
ko04713	Circadian entrainment	57/902	136/7206	4.17574718297e-18
ko04721	Synaptic vesicle cycle	41/902	80/7206	3.5615997785e-17
ko04725	Cholinergic synapse	60/902	160/7206	3.10778752422e-16
ko04742	Taste transduction	32/902	61/7206	4.69639388392e-14
ko04024	cAMP signaling pathway	79/902	279/7206	4.6955268968e-13
ko04726	Serotonergic synapse	49/902	137/7206	1.43559510486e-12
ko04911	Insulin secretion	43/902	117/7206	1.227806942e-11
ko04740	Olfactory transduction	34/902	80/7206	1.6608350876e-11
ko04020	Calcium signaling pathway	71/902	265/7206	1.4322697347e-10
ko05031	Amphetamine addiction	33/902	91/7206	4.59801164619e-09
ko04921	Oxytocin signaling pathway	57/902	209/7206	6.85379858885e-09
ko04261	Adrenergic signaling in cardiomyocytes	53/902	205/7206	1.39752032765e-07
ko03040	Spliceosome	1/902	145/7206	1.47026804635e-07
ko04720	Long-term potentiation	32/902	99/7206	1.8112183634e-07
ko05030	Cocaine addiction	26/902	73/7206	3.03974199643e-07
ko05203	Viral carcinogenesis	10/902	277/7206	3.72033685086e-07
ko05164	Influenza A	3/902	167/7206	6.93619671114e-07
ko04060	Cytokine-cytokine receptor interaction	5/902	191/7206	2.0062249639e-06
ko04970	Salivary secretion	29/902	95/7206	2.55153420648e-06
ko05166	HTLV-I infection	15/902	292/7206	2.74597613663e-05
ko05322	Systemic lupus erythematosus	4/902	151/7206	2.93021442548e-05
ko04514	Cell adhesion molecules (CAMs)	33/902	130/7206	4.60742169543e-05
ko04010	MAPK signaling pathway	65/902	321/7206	6.26187803888e-05
ko04925	Aldosterone synthesis and secretion	28/902	105/7206	7.28262811577e-05
ko04621	NOD-like receptor signaling pathway	5/902	157/7206	7.29410121357e-05
ko05168	Herpes simplex infection	7/902	182/7206	9.10836775967e-05
ko04745	Phototransduction - fly	14/902	38/7206	0.000110662341094
ko03013	RNA transport	6/902	166/7206	0.000116673285266
ko04120	Ubiquitin mediated proteolysis	4/902	138/7206	0.000126206303371
ko04260	Cardiac muscle contraction	26/902	98/7206	0.000149942742734
ko05205	Proteoglycans in cancer	15/902	271/7206	0.000160548350202
ko04730	Long-term depression	22/902	78/7206	0.000180354081376
ko05162	Measles	3/902	120/7206	0.000219873809385
ko05014	Amyotrophic lateral sclerosis (ALS)	21/902	74/7206	0.000242676585034
ko04964	Proximal tubule bicarbonate reclamation	11/902	29/7206	0.000450577852701
ko04610	Complement and coagulation cascades	1/902	79/7206	0.000489017352566
ko04971	Gastric acid secretion	25/902	98/7206	0.000531081818305
ko04141	Protein processing in endoplasmic reticulum	9/902	184/7206	0.000649590949974
ko05161	Hepatitis B	8/902	173/7206	0.000656488919915
ko04972	Pancreatic secretion	27/902	111/7206	0.00068845914631
ko04966	Collecting duct acid secretion	10/902	26/7206	0.000720018253765
ko04070	Phosphatidylinositol signaling system	27/902	112/7206	0.000731232641744
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	21/902	79/7206	0.00082137561515
ko05169	Epstein-Barr virus infection	11/902	206/7206	0.00083443504504
ko04932	Non-alcoholic fatty liver disease (NAFLD)	9/902	182/7206	0.000890595167614
ko04022	cGMP-PKG signaling pathway	44/902	216/7206	0.00108860900683
ko04072	Phospholipase D signaling pathway	40/902	197/7206	0.00203507496985
ko05215	Prostate cancer	4/902	111/7206	0.00210186167742
ko04924	Renin secretion	21/902	86/7206	0.00255191663506
ko04064	NF-kappa B signaling pathway	3/902	96/7206	0.00270904749942
ko04110	Cell cycle	7/902	145/7206	0.00319270814696
ko03008	Ribosome biogenesis in eukaryotes	2/902	79/7206	0.00322655341537
ko04140	Autophagy - animal	9/902	164/7206	0.00391834342439
ko05140	Leishmaniasis	2/902	75/7206	0.00467406112138
ko04146	Peroxisome	3/902	89/7206	0.0054449977496
ko03018	RNA degradation	3/902	84/7206	0.0076233031137
ko04630	Jak-STAT signaling pathway	7/902	132/7206	0.00775058444309
ko00562	Inositol phosphate metabolism	20/902	89/7206	0.00878501335177
ko04976	Bile secretion	18/902	80/7206	0.0104535886446
ko05016	Huntington's disease	15/902	215/7206	0.0115900131922
ko00520	Amino sugar and nucleotide sugar metabolism	1/902	55/7206	0.0120412243109
ko00480	Glutathione metabolism	1/902	55/7206	0.0120412243109
ko05200	Pathways in cancer	44/902	492/7206	0.0132861001474
ko05145	Toxoplasmosis	7/902	126/7206	0.013972376999
ko05217	Basal cell carcinoma	2/902	68/7206	0.0147236450672
ko04612	Antigen processing and presentation	3/902	77/7206	0.015181644987
ko04350	TGF-beta signaling pathway	5/902	103/7206	0.0154242041709
ko04217	Necroptosis	12/902	178/7206	0.0156992742406
ko04210	Apoptosis	12/902	180/7206	0.0159243811012
ko04710	Circadian rhythm	11/902	43/7206	0.017603928465
ko00590	Arachidonic acid metabolism	1/902	52/7206	0.0179379592702
ko05224	Breast cancer	12/902	174/7206	0.020181980715
ko05206	MicroRNAs in cancer	12/902	177/7206	0.0206185633947
ko04640	Hematopoietic cell lineage	2/902	64/7206	0.0206260966143
ko04014	Ras signaling pathway	48/902	279/7206	0.0206399892174
ko04115	p53 signaling pathway	3/902	74/7206	0.0212681418895
ko05034	Alcoholism	42/902	238/7206	0.0213533575668
ko04657	IL-17 signaling pathway	4/902	87/7206	0.0214523712694
ko01524	Platinum drug resistance	3/902	76/7206	0.0217059069797
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/902	14/7206	0.0230427445441
ko04668	TNF signaling pathway	7/902	120/7206	0.024967671129
ko00620	Pyruvate metabolism	1/902	46/7206	0.0251811913534
ko03420	Nucleotide excision repair	1/902	46/7206	0.0251811913534
ko00270	Cysteine and methionine metabolism	1/902	47/7206	0.0252390185941
ko05219	Bladder cancer	1/902	48/7206	0.0257402257723
ko04978	Mineral absorption	10/902	40/7206	0.0272659228623
ko04510	Focal adhesion	19/902	240/7206	0.0285739089177
ko05414	Dilated cardiomyopathy	22/902	112/7206	0.0296467643006
ko00330	Arginine and proline metabolism	2/902	61/7206	0.0297412692813
ko00830	Retinol metabolism	10/902	42/7206	0.0347510799202
ko03022	Basal transcription factors	1/902	44/7206	0.0372334063404
ko05144	Malaria	1/902	45/7206	0.0381253159004
ko00071	Fatty acid degradation	1/902	45/7206	0.0381253159004
ko04930	Type II diabetes mellitus	12/902	54/7206	0.0383260286633
ko05321	Inflammatory bowel disease (IBD)	2/902	56/7206	0.0409521800939
ko04150	mTOR signaling pathway	14/902	184/7206	0.0417470029681
ko04611	Platelet activation	12/902	163/7206	0.0418749376932
ko04961	Endocrine and other factor-regulated calcium reabsorption	13/902	59/7206	0.0444387440482
ko04142	Lysosome	11/902	151/7206	0.0470119349072
ko05418	Fluid shear stress and atherosclerosis	13/902	173/7206	0.0471947109976