ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 38/395 191/7206 1.72803211539e-12 ko04650 Natural killer cell mediated cytotoxicity 21/395 97/7206 4.08500785752e-08 ko04380 Osteoclast differentiation 25/395 134/7206 4.91926762566e-08 ko04610 Complement and coagulation cascades 18/395 79/7206 1.69666448219e-07 ko05340 Primary immunodeficiency 11/395 30/7206 2.48134415455e-07 ko05164 Influenza A 25/395 167/7206 3.69179692976e-06 ko00120 Primary bile acid biosynthesis 8/395 20/7206 5.34235726945e-06 ko05321 Inflammatory bowel disease (IBD) 13/395 56/7206 7.22959104611e-06 ko05152 Tuberculosis 26/395 187/7206 9.43264310197e-06 ko05150 Staphylococcus aureus infection 10/395 36/7206 1.53590534257e-05 ko04672 Intestinal immune network for IgA production 10/395 37/7206 2.00330140176e-05 ko04660 T cell receptor signaling pathway 19/395 124/7206 3.94283906945e-05 ko05140 Leishmaniasis 14/395 75/7206 4.56901938325e-05 ko00140 Steroid hormone biosynthesis 10/395 41/7206 5.29253097041e-05 ko05162 Measles 18/395 120/7206 8.36248796831e-05 ko05320 Autoimmune thyroid disease 8/395 29/7206 0.000117610359953 ko05167 Kaposi's sarcoma-associated herpesvirus infection 24/395 191/7206 0.000128030570581 ko05330 Allograft rejection 7/395 24/7206 0.000216254796102 ko04217 Necroptosis 22/395 178/7206 0.000307294822725 ko04146 Peroxisome 14/395 89/7206 0.000308259550893 ko05145 Toxoplasmosis 17/395 126/7206 0.000479218344143 ko05418 Fluid shear stress and atherosclerosis 21/395 173/7206 0.000523269815054 ko00982 Drug metabolism - cytochrome P450 8/395 37/7206 0.00071903170985 ko04630 Jak-STAT signaling pathway 17/395 132/7206 0.000824207434588 ko04612 Antigen processing and presentation 12/395 77/7206 0.000893320722628 ko04620 Toll-like receptor signaling pathway 14/395 100/7206 0.00102979903161 ko04621 NOD-like receptor signaling pathway 19/395 157/7206 0.00103201345338 ko04723 Retrograde endocannabinoid signaling 1/395 175/7206 0.00107423407614 ko05034 Alcoholism 3/395 238/7206 0.00125679113028 ko04145 Phagosome 19/395 162/7206 0.00141612727074 ko03013 RNA transport 1/395 166/7206 0.00154311252689 ko04137 Mitophagy - animal 12/395 82/7206 0.00157254906064 ko00350 Tyrosine metabolism 7/395 33/7206 0.00174013141482 ko04659 Th17 cell differentiation 14/395 106/7206 0.00182660823999 ko04064 NF-kappa B signaling pathway 13/395 96/7206 0.00209711290896 ko05332 Graft-versus-host disease 5/395 18/7206 0.00228177483548 ko05168 Herpes simplex infection 20/395 182/7206 0.00256719634797 ko05144 Malaria 8/395 45/7206 0.00273441240208 ko04662 B cell receptor signaling pathway 12/395 88/7206 0.00289877205266 ko00592 alpha-Linolenic acid metabolism 5/395 19/7206 0.00295932264897 ko05323 Rheumatoid arthritis 12/395 89/7206 0.00318935733466 ko04933 AGE-RAGE signaling pathway in diabetic complications 16/395 135/7206 0.00324837466524 ko04611 Platelet activation 18/395 163/7206 0.00439750639192 ko04916 Melanogenesis 1/395 142/7206 0.00476019623696 ko03040 Spliceosome 1/395 145/7206 0.00482211309614 ko00980 Metabolism of xenobiotics by cytochrome P450 7/395 40/7206 0.00545736308617 ko00590 Arachidonic acid metabolism 8/395 52/7206 0.0068352622934 ko04640 Hematopoietic cell lineage 9/395 64/7206 0.00769147782259 ko01524 Platinum drug resistance 10/395 76/7206 0.00813888860046 ko04664 Fc epsilon RI signaling pathway 10/395 77/7206 0.00891158268302 ko00480 Glutathione metabolism 8/395 55/7206 0.00958944661426 ko03010 Ribosome 1/395 129/7206 0.010080558292 ko01040 Biosynthesis of unsaturated fatty acids 5/395 25/7206 0.0103136227701 ko04062 Chemokine signaling pathway 20/395 201/7206 0.0105795322309 ko04080 Neuroactive ligand-receptor interaction 12/395 423/7206 0.0110035989958 ko05310 Asthma 4/395 17/7206 0.0119696110908 ko00360 Phenylalanine metabolism 4/395 17/7206 0.0119696110908 ko03320 PPAR signaling pathway 9/395 69/7206 0.0124528073349 ko04390 Hippo signaling pathway 3/395 188/7206 0.0136095656558 ko00950 Isoquinoline alkaloid biosynthesis 3/395 10/7206 0.0146944641499 ko05204 Chemical carcinogenesis 7/395 48/7206 0.0148152365368 ko05161 Hepatitis B 17/395 173/7206 0.0169377535651 ko04310 Wnt signaling pathway 3/395 181/7206 0.0189454537184 ko04658 Th1 and Th2 cell differentiation 11/395 96/7206 0.0197689362359 ko05202 Transcriptional misregulation in cancer 18/395 188/7206 0.021124346898 ko04911 Insulin secretion 1/395 117/7206 0.021612090347 ko05132 Salmonella infection 11/395 98/7206 0.0216715698777 ko04666 Fc gamma R-mediated phagocytosis 13/395 122/7206 0.0237768382927 ko00100 Steroid biosynthesis 4/395 21/7206 0.0253287750718 ko05224 Breast cancer 3/395 174/7206 0.026290355615 ko05010 Alzheimer's disease 4/395 202/7206 0.0262912515618 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/395 5/7206 0.0268364649461 ko00281 Geraniol degradation 2/395 5/7206 0.0268364649461 ko04670 Leukocyte transendothelial migration 15/395 151/7206 0.0272243638607 ko05133 Pertussis 10/395 87/7206 0.0272524160991 ko04940 Type I diabetes mellitus 5/395 32/7206 0.0285937020321 ko04925 Aldosterone synthesis and secretion 1/395 105/7206 0.030414791467 ko05032 Morphine addiction 1/395 110/7206 0.0313150730599 ko04713 Circadian entrainment 2/395 136/7206 0.0344512813241 ko04114 Oocyte meiosis 2/395 139/7206 0.0353647566419 ko04020 Calcium signaling pathway 7/395 265/7206 0.0380359396285 ko04971 Gastric acid secretion 1/395 98/7206 0.0437873449925 ko04720 Long-term potentiation 1/395 99/7206 0.0438415623218 ko04142 Lysosome 14/395 151/7206 0.0460127612655 ko04728 Dopaminergic synapse 4/395 185/7206 0.0473600201584 ko00330 Arginine and proline metabolism 7/395 61/7206 0.0480684001213 ko04540 Gap junction 2/395 128/7206 0.0480772246912 ko05012 Parkinson's disease 3/395 155/7206 0.0483720468711