ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	197/1185	423/7206	4.3388298917e-51
ko04724	Glutamatergic synapse	90/1185	152/7206	1.45797262213e-33
ko05033	Nicotine addiction	49/1185	56/7206	1.17614004779e-31
ko04713	Circadian entrainment	81/1185	136/7206	1.56437750705e-30
ko05032	Morphine addiction	70/1185	110/7206	4.60612295704e-29
ko04727	GABAergic synapse	67/1185	110/7206	3.18156748345e-26
ko04725	Cholinergic synapse	79/1185	160/7206	1.50375656461e-22
ko04728	Dopaminergic synapse	86/1185	185/7206	3.36168064926e-22
ko04723	Retrograde endocannabinoid signaling	81/1185	175/7206	8.15326723535e-21
ko04024	cAMP signaling pathway	107/1185	279/7206	3.25070393436e-19
ko04721	Synaptic vesicle cycle	47/1185	80/7206	7.82534550695e-18
ko04020	Calcium signaling pathway	99/1185	265/7206	6.78647236286e-17
ko04911	Insulin secretion	57/1185	117/7206	3.05562220282e-16
ko04921	Oxytocin signaling pathway	82/1185	209/7206	1.00811503829e-15
ko04742	Taste transduction	37/1185	61/7206	6.22002268404e-15
ko04726	Serotonergic synapse	57/1185	137/7206	1.51654024435e-12
ko04261	Adrenergic signaling in cardiomyocytes	75/1185	205/7206	1.92217895611e-12
ko04360	Axon guidance	80/1185	233/7206	1.48496676674e-11
ko05031	Amphetamine addiction	42/1185	91/7206	2.49948181183e-11
ko04720	Long-term potentiation	44/1185	99/7206	4.02398724076e-11
ko03040	Spliceosome	1/1185	145/7206	1.92409247761e-10
ko04744	Phototransduction	23/1185	36/7206	2.01587621036e-10
ko04970	Salivary secretion	41/1185	95/7206	5.67188453134e-10
ko04740	Olfactory transduction	36/1185	80/7206	1.59869613688e-09
ko04925	Aldosterone synthesis and secretion	42/1185	105/7206	5.71879782066e-09
ko05030	Cocaine addiction	32/1185	73/7206	2.83386087574e-08
ko04022	cGMP-PKG signaling pathway	68/1185	216/7206	3.46882137516e-08
ko05322	Systemic lupus erythematosus	4/1185	151/7206	8.72791683842e-08
ko04971	Gastric acid secretion	38/1185	98/7206	1.01394907518e-07
ko05203	Viral carcinogenesis	18/1185	277/7206	8.05006834064e-07
ko04060	Cytokine-cytokine receptor interaction	9/1185	191/7206	8.23617913086e-07
ko04010	MAPK signaling pathway	87/1185	321/7206	9.4251665845e-07
ko03013	RNA transport	7/1185	166/7206	1.27945333992e-06
ko05168	Herpes simplex infection	9/1185	182/7206	2.35898864215e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1185	74/7206	8.77759952572e-06
ko05164	Influenza A	9/1185	167/7206	1.87529246916e-05
ko04610	Complement and coagulation cascades	1/1185	79/7206	2.04951240562e-05
ko04072	Phospholipase D signaling pathway	56/1185	197/7206	2.17668432188e-05
ko04014	Ras signaling pathway	73/1185	279/7206	2.36475764599e-05
ko04972	Pancreatic secretion	36/1185	111/7206	2.62197941711e-05
ko04730	Long-term depression	28/1185	78/7206	3.53487648062e-05
ko04745	Phototransduction - fly	17/1185	38/7206	3.79033308365e-05
ko04141	Protein processing in endoplasmic reticulum	12/1185	184/7206	7.28819474357e-05
ko04371	Apelin signaling pathway	50/1185	177/7206	7.7648853137e-05
ko04070	Phosphatidylinositol signaling system	35/1185	112/7206	8.78654543459e-05
ko04924	Renin secretion	29/1185	86/7206	9.13285427685e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1185	79/7206	9.59651508292e-05
ko04514	Cell adhesion molecules (CAMs)	39/1185	130/7206	0.000103648589353
ko03008	Ribosome biogenesis in eukaryotes	2/1185	79/7206	0.000173022299288
ko04621	NOD-like receptor signaling pathway	10/1185	157/7206	0.000193575419687
ko05414	Dilated cardiomyopathy	34/1185	112/7206	0.000249841471453
ko04612	Antigen processing and presentation	2/1185	77/7206	0.000264210665998
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1185	59/7206	0.000294730525139
ko04110	Cell cycle	9/1185	145/7206	0.00038093972965
ko04540	Gap junction	37/1185	128/7206	0.000400794189439
ko04120	Ubiquitin mediated proteolysis	9/1185	138/7206	0.000695672444683
ko04750	Inflammatory mediator regulation of TRP channels	35/1185	122/7206	0.00074326322197
ko05110	Vibrio cholerae infection	21/1185	63/7206	0.000900500635603
ko04915	Estrogen signaling pathway	36/1185	131/7206	0.00120478107176
ko04064	NF-kappa B signaling pathway	5/1185	96/7206	0.0012738655458
ko04260	Cardiac muscle contraction	29/1185	98/7206	0.00134259930695
ko00520	Amino sugar and nucleotide sugar metabolism	1/1185	55/7206	0.00138700540033
ko05205	Proteoglycans in cancer	26/1185	271/7206	0.00142373689661
ko05169	Epstein-Barr virus infection	18/1185	206/7206	0.00157242690396
ko04966	Collecting duct acid secretion	11/1185	26/7206	0.00159152122047
ko04923	Regulation of lipolysis in adipocytes	24/1185	77/7206	0.00160567196857
ko04640	Hematopoietic cell lineage	2/1185	64/7206	0.00183667509405
ko04976	Bile secretion	24/1185	80/7206	0.00215209763655
ko04930	Type II diabetes mellitus	18/1185	54/7206	0.00243149903176
ko05162	Measles	8/1185	120/7206	0.00257545280482
ko00330	Arginine and proline metabolism	2/1185	61/7206	0.00265912621205
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1185	182/7206	0.00322869369356
ko04146	Peroxisome	5/1185	89/7206	0.00357952642215
ko04015	Rap1 signaling pathway	64/1185	278/7206	0.00375921822753
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1185	14/7206	0.00376315442708
ko03420	Nucleotide excision repair	1/1185	46/7206	0.00440933260142
ko00480	Glutathione metabolism	2/1185	55/7206	0.00565579383819
ko05321	Inflammatory bowel disease (IBD)	2/1185	56/7206	0.00573468914061
ko04912	GnRH signaling pathway	32/1185	122/7206	0.00622199524507
ko00240	Pyrimidine metabolism	8/1185	110/7206	0.00624621907212
ko03022	Basal transcription factors	1/1185	44/7206	0.00671520799598
ko05140	Leishmaniasis	4/1185	75/7206	0.00695027367928
ko03018	RNA degradation	5/1185	84/7206	0.00700374669973
ko05144	Malaria	1/1185	45/7206	0.00708789681315
ko00071	Fatty acid degradation	1/1185	45/7206	0.00708789681315
ko04270	Vascular smooth muscle contraction	38/1185	154/7206	0.00801327552599
ko00590	Arachidonic acid metabolism	2/1185	52/7206	0.00829195518155
ko04622	RIG-I-like receptor signaling pathway	3/1185	62/7206	0.00919372383209
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1185	40/7206	0.00993282770638
ko04217	Necroptosis	17/1185	178/7206	0.0102340698986
ko04916	Melanogenesis	35/1185	142/7206	0.0114035488101
ko00380	Tryptophan metabolism	2/1185	50/7206	0.0120465244406
ko04658	Th1 and Th2 cell differentiation	7/1185	96/7206	0.0120950755909
ko04657	IL-17 signaling pathway	6/1185	87/7206	0.0127749626972
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1185	100/7206	0.0138186579606
ko03410	Base excision repair	1/1185	38/7206	0.0148058115889
ko05161	Hepatitis B	17/1185	173/7206	0.0165368881855
ko00260	Glycine, serine and threonine metabolism	2/1185	48/7206	0.0176079763026
ko04918	Thyroid hormone synthesis	23/1185	86/7206	0.0179614296498
ko04626	Plant-pathogen interaction	7/1185	18/7206	0.0191121745353
ko05016	Huntington's disease	23/1185	215/7206	0.019367575594
ko00500	Starch and sucrose metabolism	1/1185	35/7206	0.0221788990057
ko00982	Drug metabolism - cytochrome P450	1/1185	37/7206	0.0230470864475
ko05131	Shigellosis	6/1185	82/7206	0.0236462056397
ko04214	Apoptosis - fly	5/1185	72/7206	0.0250006916963
ko00310	Lysine degradation	5/1185	73/7206	0.025146885194
ko04115	p53 signaling pathway	5/1185	74/7206	0.0256912512153
ko00620	Pyruvate metabolism	2/1185	46/7206	0.0258601234556
ko00280	Valine, leucine and isoleucine degradation	3/1185	54/7206	0.0263475743659
ko04114	Oocyte meiosis	33/1185	139/7206	0.0272590222306
ko05133	Pertussis	7/1185	87/7206	0.0292919661989
ko01200	Carbon metabolism	12/1185	128/7206	0.0296722371399
ko00640	Propanoate metabolism	1/1185	34/7206	0.0336465948958
ko00983	Drug metabolism - other enzymes	2/1185	42/7206	0.0365686222327
ko05215	Prostate cancer	10/1185	111/7206	0.0377422817747
ko04722	Neurotrophin signaling pathway	36/1185	160/7206	0.0404785599702
ko04620	Toll-like receptor signaling pathway	9/1185	100/7206	0.0415187683513
ko04630	Jak-STAT signaling pathway	13/1185	132/7206	0.0430188858592
ko00512	Mucin type O-glycan biosynthesis	9/1185	29/7206	0.0433697298824
ko04964	Proximal tubule bicarbonate reclamation	9/1185	29/7206	0.0433697298824
ko04711	Circadian rhythm - fly	5/1185	13/7206	0.0484742680435
ko05418	Fluid shear stress and atherosclerosis	19/1185	173/7206	0.0487103228155
ko05340	Primary immunodeficiency	1/1185	30/7206	0.0490818841885