ko pathway ratio_in_study ratio_in_pop p_value ko04070 Phosphatidylinositol signaling system 17/219 112/7206 3.60398762419e-08 ko04072 Phospholipase D signaling pathway 21/219 197/7206 4.63484328919e-07 ko04724 Glutamatergic synapse 18/219 152/7206 6.78385207837e-07 ko04020 Calcium signaling pathway 23/219 265/7206 4.81798650653e-06 ko04911 Insulin secretion 13/219 117/7206 5.00016073533e-05 ko04080 Neuroactive ligand-receptor interaction 28/219 423/7206 9.47450414549e-05 ko04024 cAMP signaling pathway 21/219 279/7206 0.00010552324175 ko04925 Aldosterone synthesis and secretion 11/219 105/7206 0.00032162825821 ko00562 Inositol phosphate metabolism 10/219 89/7206 0.000340784747163 ko04725 Cholinergic synapse 14/219 160/7206 0.000342781791219 ko04727 GABAergic synapse 11/219 110/7206 0.000481880283927 ko05032 Morphine addiction 11/219 110/7206 0.000481880283927 ko04970 Salivary secretion 10/219 95/7206 0.000577863076265 ko05231 Choline metabolism in cancer 12/219 134/7206 0.000737122446822 ko04726 Serotonergic synapse 12/219 137/7206 0.000897790989278 ko05033 Nicotine addiction 7/219 56/7206 0.00142149818464 ko04921 Oxytocin signaling pathway 15/219 209/7206 0.00168589327579 ko00750 Vitamin B6 metabolism 3/219 9/7206 0.00203085231134 ko04723 Retrograde endocannabinoid signaling 13/219 175/7206 0.00251235716567 ko04713 Circadian entrainment 11/219 136/7206 0.00276235995329 ko04750 Inflammatory mediator regulation of TRP channels 10/219 122/7206 0.00386977807777 ko04261 Adrenergic signaling in cardiomyocytes 14/219 205/7206 0.00539201156213 ko04972 Pancreatic secretion 9/219 111/7206 0.00647108986649 ko00604 Glycosphingolipid biosynthesis - ganglio series 3/219 14/7206 0.00786477800944 ko04971 Gastric acid secretion 8/219 98/7206 0.00965395339059 ko04720 Long-term potentiation 8/219 99/7206 0.0102362323501 ko04151 PI3K-Akt signaling pathway 4/219 390/7206 0.0140590295646 ko05203 Viral carcinogenesis 2/219 277/7206 0.0182868424733 ko05169 Epstein-Barr virus infection 1/219 206/7206 0.0219202562379 ko04144 Endocytosis 18/219 342/7206 0.0221412842032 ko05030 Cocaine addiction 6/219 73/7206 0.0230845733863 ko04139 Mitophagy - yeast 4/219 37/7206 0.0250169424716 ko00250 Alanine, aspartate and glutamate metabolism 4/219 38/7206 0.0273144385239 ko04923 Regulation of lipolysis in adipocytes 6/219 77/7206 0.0291226570655 ko00564 Glycerophospholipid metabolism 7/219 99/7206 0.0306179066062 ko04721 Synaptic vesicle cycle 6/219 80/7206 0.0342770725009 ko00220 Arginine biosynthesis 3/219 24/7206 0.0350194515992 ko04022 cGMP-PKG signaling pathway 12/219 216/7206 0.0406805001931 ko00561 Glycerolipid metabolism 5/219 63/7206 0.041893707133 ko05168 Herpes simplex infection 1/219 182/7206 0.0457709326153 ko04141 Protein processing in endoplasmic reticulum 1/219 184/7206 0.0462288988056 ko04918 Thyroid hormone synthesis 6/219 86/7206 0.0462704093741