ko pathway ratio_in_study ratio_in_pop p_value ko04921 Oxytocin signaling pathway 44/684 209/7206 2.64646194577e-07 ko04925 Aldosterone synthesis and secretion 26/684 105/7206 3.40904153524e-06 ko04020 Calcium signaling pathway 49/684 265/7206 4.89889303148e-06 ko04922 Glucagon signaling pathway 29/684 128/7206 8.9234875111e-06 ko04713 Circadian entrainment 30/684 136/7206 8.98129552069e-06 ko04270 Vascular smooth muscle contraction 32/684 154/7206 1.78329748736e-05 ko04710 Circadian rhythm 14/684 43/7206 2.42489336733e-05 ko00120 Primary bile acid biosynthesis 9/684 20/7206 3.81290152826e-05 ko03010 Ribosome 1/684 129/7206 5.5492000902e-05 ko04022 cGMP-PKG signaling pathway 39/684 216/7206 7.62264829589e-05 ko04745 Phototransduction - fly 12/684 38/7206 0.000129157785643 ko04371 Apelin signaling pathway 33/684 177/7206 0.000129964077997 ko03040 Spliceosome 2/684 145/7206 0.000137939795133 ko04144 Endocytosis 14/684 342/7206 0.000199839486969 ko00010 Glycolysis / Gluconeogenesis 17/684 74/7206 0.000438681633726 ko04970 Salivary secretion 20/684 95/7206 0.000557842362375 ko04650 Natural killer cell mediated cytotoxicity 20/684 97/7206 0.000703590706889 ko04110 Cell cycle 3/684 145/7206 0.000790050703846 ko04971 Gastric acid secretion 20/684 98/7206 0.000793003625873 ko04137 Mitophagy - animal 18/684 82/7206 0.000809588605833 ko04380 Osteoclast differentiation 25/684 134/7206 0.000869932470635 ko04724 Glutamatergic synapse 27/684 152/7206 0.00115834491467 ko04720 Long-term potentiation 20/684 99/7206 0.00140050783917 ko00051 Fructose and mannose metabolism 11/684 42/7206 0.00143065476376 ko04725 Cholinergic synapse 28/684 160/7206 0.00143609424463 ko04727 GABAergic synapse 21/684 110/7206 0.00156466708676 ko05322 Systemic lupus erythematosus 4/684 151/7206 0.00174596949593 ko04911 Insulin secretion 22/684 117/7206 0.0020063834688 ko04261 Adrenergic signaling in cardiomyocytes 33/684 205/7206 0.00228412881099 ko04730 Long-term depression 16/684 78/7206 0.00270320888086 ko04750 Inflammatory mediator regulation of TRP channels 22/684 122/7206 0.00273703105321 ko04070 Phosphatidylinositol signaling system 21/684 112/7206 0.00280196956949 ko04726 Serotonergic synapse 24/684 137/7206 0.00285128513121 ko04066 HIF-1 signaling pathway 22/684 123/7206 0.00295495036065 ko05031 Amphetamine addiction 18/684 91/7206 0.00309314188618 ko00620 Pyruvate metabolism 11/684 46/7206 0.00314126259564 ko04626 Plant-pathogen interaction 6/684 18/7206 0.00489966313857 ko04060 Cytokine-cytokine receptor interaction 30/684 191/7206 0.00548410689394 ko00592 alpha-Linolenic acid metabolism 6/684 19/7206 0.00659612198114 ko03013 RNA transport 6/684 166/7206 0.00675539441401 ko04924 Renin secretion 16/684 86/7206 0.0081446973177 ko04611 Platelet activation 26/684 163/7206 0.00938126234255 ko04080 Neuroactive ligand-receptor interaction 56/684 423/7206 0.0100198579299 ko04610 Complement and coagulation cascades 15/684 79/7206 0.0100609998134 ko04068 FoxO signaling pathway 26/684 167/7206 0.0105745960105 ko00710 Carbon fixation in photosynthetic organisms 7/684 27/7206 0.0110328244366 ko04138 Autophagy - yeast 15/684 81/7206 0.0112693298344 ko00680 Methane metabolism 8/684 34/7206 0.0123712438156 ko03320 PPAR signaling pathway 13/684 69/7206 0.0128673163263 ko05152 Tuberculosis 28/684 187/7206 0.0154247840573 ko05203 Viral carcinogenesis 15/684 277/7206 0.0158821745565 ko05167 Kaposi's sarcoma-associated herpesvirus infection 28/684 191/7206 0.0173155106273 ko05340 Primary immunodeficiency 7/684 30/7206 0.0197203216276 ko05230 Central carbon metabolism in cancer 14/684 81/7206 0.0220346199972 ko01200 Carbon metabolism 20/684 128/7206 0.022120883015 ko04540 Gap junction 20/684 128/7206 0.022120883015 ko04136 Autophagy - other 7/684 31/7206 0.0234521304776 ko04213 Longevity regulating pathway - multiple species 15/684 86/7206 0.0236530052915 ko00380 Tryptophan metabolism 10/684 50/7206 0.0240292885479 ko05224 Breast cancer 8/684 174/7206 0.0250205158285 ko04072 Phospholipase D signaling pathway 28/684 197/7206 0.0263528919956 ko04146 Peroxisome 15/684 89/7206 0.0266828182595 ko04966 Collecting duct acid secretion 6/684 26/7206 0.0316572767951 ko05034 Alcoholism 13/684 238/7206 0.0318082602242 ko00350 Tyrosine metabolism 7/684 33/7206 0.0323141335083 ko04930 Type II diabetes mellitus 10/684 54/7206 0.0331545550139 ko04024 cAMP signaling pathway 37/684 279/7206 0.0364157895985 ko01230 Biosynthesis of amino acids 14/684 85/7206 0.0381038081288 ko05032 Morphine addiction 17/684 110/7206 0.0465300423266