ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 30/278 191/7206 3.00591535149e-11 ko04380 Osteoclast differentiation 25/278 134/7206 3.19732639868e-11 ko05164 Influenza A 27/278 167/7206 1.5826345436e-10 ko04621 NOD-like receptor signaling pathway 23/278 157/7206 2.68710264602e-08 ko05162 Measles 19/278 120/7206 1.29775122552e-07 ko05167 Kaposi's sarcoma-associated herpesvirus infection 24/278 191/7206 2.64770470116e-07 ko05145 Toxoplasmosis 19/278 126/7206 2.86804264874e-07 ko05160 Hepatitis C 21/278 153/7206 3.44521368881e-07 ko04064 NF-kappa B signaling pathway 16/278 96/7206 6.40702776978e-07 ko04668 TNF signaling pathway 18/278 120/7206 6.44595895612e-07 ko04650 Natural killer cell mediated cytotoxicity 16/278 97/7206 7.40978281858e-07 ko05168 Herpes simplex infection 22/278 182/7206 1.65703287924e-06 ko05152 Tuberculosis 22/278 187/7206 2.62059514292e-06 ko04658 Th1 and Th2 cell differentiation 15/278 96/7206 3.35157288967e-06 ko04620 Toll-like receptor signaling pathway 15/278 100/7206 5.64765160458e-06 ko05321 Inflammatory bowel disease (IBD) 11/278 56/7206 7.32434365676e-06 ko04217 Necroptosis 20/278 178/7206 1.51753401495e-05 ko05161 Hepatitis B 18/278 173/7206 0.000112428941739 ko04622 RIG-I-like receptor signaling pathway 10/278 62/7206 0.000112888095588 ko05140 Leishmaniasis 11/278 75/7206 0.000125540376108 ko04630 Jak-STAT signaling pathway 15/278 132/7206 0.000158031679448 ko04664 Fc epsilon RI signaling pathway 11/278 77/7206 0.00015991676677 ko04710 Circadian rhythm 8/278 43/7206 0.000198284906605 ko04659 Th17 cell differentiation 13/278 106/7206 0.000201728365578 ko04610 Complement and coagulation cascades 11/278 79/7206 0.000201980273855 ko04660 T cell receptor signaling pathway 14/278 124/7206 0.000279489633938 ko04672 Intestinal immune network for IgA production 7/278 37/7206 0.000448567982897 ko04611 Platelet activation 16/278 163/7206 0.000521716877018 ko05340 Primary immunodeficiency 6/278 30/7206 0.00084800986723 ko05230 Central carbon metabolism in cancer 10/278 81/7206 0.00103421824702 ko05142 Chagas disease (American trypanosomiasis) 13/278 130/7206 0.00145186453839 ko04657 IL-17 signaling pathway 10/278 87/7206 0.00179794095906 ko05133 Pertussis 10/278 87/7206 0.00179794095906 ko04662 B cell receptor signaling pathway 10/278 88/7206 0.00196101815819 ko05323 Rheumatoid arthritis 10/278 89/7206 0.00213583425224 ko04062 Chemokine signaling pathway 17/278 201/7206 0.00221279158756 ko05150 Staphylococcus aureus infection 6/278 36/7206 0.00229100783307 ko04666 Fc gamma R-mediated phagocytosis 12/278 122/7206 0.00252034095478 ko05169 Epstein-Barr virus infection 17/278 206/7206 0.00271647446761 ko00590 Arachidonic acid metabolism 7/278 52/7206 0.00355951591416 ko00140 Steroid hormone biosynthesis 6/278 41/7206 0.00450185113788 ko04960 Aldosterone-regulated sodium reabsorption 6/278 41/7206 0.00450185113788 ko04210 Apoptosis 15/278 180/7206 0.00471983926747 ko04933 AGE-RAGE signaling pathway in diabetic complications 12/278 135/7206 0.00576492046212 ko04917 Prolactin signaling pathway 9/278 87/7206 0.00611372750416 ko00562 Inositol phosphate metabolism 9/278 89/7206 0.00708755698009 ko05215 Prostate cancer 10/278 111/7206 0.0103241478295 ko04070 Phosphatidylinositol signaling system 10/278 112/7206 0.0109627354508 ko05166 HTLV-I infection 20/278 292/7206 0.011953475049 ko05330 Allograft rejection 4/278 24/7206 0.0125167037332 ko04072 Phospholipase D signaling pathway 15/278 197/7206 0.0125174068232 ko04080 Neuroactive ligand-receptor interaction 7/278 423/7206 0.0126764608753 ko05132 Salmonella infection 9/278 98/7206 0.0130074549274 ko05131 Shigellosis 8/278 82/7206 0.0133582512807 ko04670 Leukocyte transendothelial migration 12/278 151/7206 0.0160319022175 ko04623 Cytosolic DNA-sensing pathway 5/278 41/7206 0.0198339335463 ko00051 Fructose and mannose metabolism 5/278 42/7206 0.0218268931651 ko05320 Autoimmune thyroid disease 4/278 29/7206 0.0240783490347 ko05120 Epithelial cell signaling in Helicobacter pylori infection 8/278 92/7206 0.0251421764021 ko04919 Thyroid hormone signaling pathway 11/278 143/7206 0.0254326761594 ko05310 Asthma 3/278 17/7206 0.0258598878651 ko01524 Platinum drug resistance 7/278 76/7206 0.0266787415704 ko04066 HIF-1 signaling pathway 10/278 123/7206 0.027705121959 ko04612 Antigen processing and presentation 7/278 77/7206 0.0284169636587 ko05144 Malaria 5/278 45/7206 0.0285703511322 ko05332 Graft-versus-host disease 3/278 18/7206 0.0301674934533 ko05034 Alcoholism 3/278 238/7206 0.0372088046452 ko04068 FoxO signaling pathway 12/278 167/7206 0.0378428023371 ko05212 Pancreatic cancer 7/278 83/7206 0.0404658472965 ko04931 Insulin resistance 10/278 137/7206 0.04294132879 ko03040 Spliceosome 1/278 145/7206 0.0459310776827 ko04110 Cell cycle 1/278 145/7206 0.0459310776827