ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	195/1110	423/7206	1.66487132161e-54
ko04724	Glutamatergic synapse	90/1110	152/7206	6.8174385634e-36
ko05033	Nicotine addiction	49/1110	56/7206	4.85135805679e-33
ko04713	Circadian entrainment	75/1110	136/7206	3.03987284339e-27
ko05032	Morphine addiction	66/1110	110/7206	5.23180363338e-27
ko04727	GABAergic synapse	64/1110	110/7206	3.66972783956e-25
ko04728	Dopaminergic synapse	85/1110	185/7206	1.66308738112e-23
ko04721	Synaptic vesicle cycle	50/1110	80/7206	7.41799635224e-22
ko04725	Cholinergic synapse	75/1110	160/7206	1.67572716148e-21
ko04723	Retrograde endocannabinoid signaling	77/1110	175/7206	5.75612157099e-20
ko04024	cAMP signaling pathway	102/1110	279/7206	8.08085935069e-19
ko04020	Calcium signaling pathway	98/1110	265/7206	1.44869104824e-18
ko04911	Insulin secretion	55/1110	117/7206	3.89380767499e-16
ko04742	Taste transduction	37/1110	61/7206	7.09758609036e-16
ko04921	Oxytocin signaling pathway	79/1110	209/7206	1.25751985661e-15
ko04726	Serotonergic synapse	57/1110	137/7206	8.76622569762e-14
ko05031	Amphetamine addiction	43/1110	91/7206	5.46936127657e-13
ko04720	Long-term potentiation	45/1110	99/7206	8.86025427306e-13
ko04261	Adrenergic signaling in cardiomyocytes	72/1110	205/7206	1.85768583627e-12
ko04970	Salivary secretion	43/1110	95/7206	3.42456524365e-12
ko04744	Phototransduction	23/1110	36/7206	5.14326821174e-11
ko03040	Spliceosome	1/1110	145/7206	1.41125485898e-09
ko05203	Viral carcinogenesis	12/1110	277/7206	4.46468810784e-09
ko04925	Aldosterone synthesis and secretion	40/1110	105/7206	1.00682611089e-08
ko04971	Gastric acid secretion	38/1110	98/7206	1.33591958199e-08
ko04022	cGMP-PKG signaling pathway	66/1110	216/7206	1.35938042931e-08
ko04740	Olfactory transduction	33/1110	80/7206	2.02488902255e-08
ko05030	Cocaine addiction	30/1110	73/7206	9.86775386429e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1110	74/7206	1.41882489668e-07
ko04360	Axon guidance	67/1110	233/7206	1.45727136632e-07
ko05168	Herpes simplex infection	6/1110	182/7206	1.90669824307e-07
ko04060	Cytokine-cytokine receptor interaction	7/1110	191/7206	2.32440313904e-07
ko05322	Systemic lupus erythematosus	5/1110	151/7206	2.04774477477e-06
ko04010	MAPK signaling pathway	81/1110	321/7206	2.60851761196e-06
ko04514	Cell adhesion molecules (CAMs)	41/1110	130/7206	3.26444007434e-06
ko04966	Collecting duct acid secretion	14/1110	26/7206	6.09518121193e-06
ko03013	RNA transport	7/1110	166/7206	6.12113990078e-06
ko04924	Renin secretion	30/1110	86/7206	6.45192764325e-06
ko04972	Pancreatic secretion	36/1110	111/7206	6.70684207557e-06
ko04745	Phototransduction - fly	17/1110	38/7206	1.57279150833e-05
ko04540	Gap junction	39/1110	128/7206	1.72274118028e-05
ko04730	Long-term depression	27/1110	78/7206	2.22196628937e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1110	79/7206	2.79782897472e-05
ko04141	Protein processing in endoplasmic reticulum	10/1110	184/7206	4.3186322605e-05
ko04072	Phospholipase D signaling pathway	52/1110	197/7206	5.24624741788e-05
ko04070	Phosphatidylinositol signaling system	34/1110	112/7206	5.3910466873e-05
ko04120	Ubiquitin mediated proteolysis	6/1110	138/7206	6.54458493582e-05
ko04621	NOD-like receptor signaling pathway	8/1110	157/7206	7.5660256971e-05
ko05164	Influenza A	9/1110	167/7206	7.86646471094e-05
ko04260	Cardiac muscle contraction	30/1110	98/7206	0.00011393599467
ko05110	Vibrio cholerae infection	22/1110	63/7206	0.000125614800385
ko05414	Dilated cardiomyopathy	33/1110	112/7206	0.000163215600777
ko05205	Proteoglycans in cancer	21/1110	271/7206	0.000202233652739
ko05169	Epstein-Barr virus infection	14/1110	206/7206	0.000253887662347
ko04750	Inflammatory mediator regulation of TRP channels	34/1110	122/7206	0.000343492124744
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1110	59/7206	0.000373948740049
ko04110	Cell cycle	8/1110	145/7206	0.000410584189064
ko03008	Ribosome biogenesis in eukaryotes	2/1110	79/7206	0.000414681810485
ko05140	Leishmaniasis	2/1110	75/7206	0.000594812867713
ko04612	Antigen processing and presentation	2/1110	77/7206	0.000634550124613
ko04976	Bile secretion	24/1110	80/7206	0.000853595535953
ko04064	NF-kappa B signaling pathway	4/1110	96/7206	0.000886080053273
ko05161	Hepatitis B	12/1110	173/7206	0.000894291799406
ko04014	Ras signaling pathway	63/1110	279/7206	0.00124196692299
ko04915	Estrogen signaling pathway	34/1110	131/7206	0.00141769421656
ko05162	Measles	7/1110	120/7206	0.00198348272018
ko04371	Apelin signaling pathway	43/1110	177/7206	0.00204621960938
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1110	14/7206	0.00255762572918
ko04964	Proximal tubule bicarbonate reclamation	11/1110	29/7206	0.00261821653788
ko04146	Peroxisome	4/1110	89/7206	0.0026605042305
ko04640	Hematopoietic cell lineage	2/1110	64/7206	0.00278185883882
ko04626	Plant-pathogen interaction	8/1110	18/7206	0.0031885917927
ko04923	Regulation of lipolysis in adipocytes	22/1110	77/7206	0.0035987600535
ko05166	HTLV-I infection	28/1110	292/7206	0.00371200203208
ko00330	Arginine and proline metabolism	2/1110	61/7206	0.00407826075723
ko04330	Notch signaling pathway	2/1110	62/7206	0.00408752238613
ko04630	Jak-STAT signaling pathway	9/1110	132/7206	0.00471481950763
ko00310	Lysine degradation	3/1110	73/7206	0.0048430507937
ko00240	Pyrimidine metabolism	7/1110	110/7206	0.00506727811029
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1110	100/7206	0.00507142439743
ko04140	Autophagy - animal	13/1110	164/7206	0.00591126195883
ko03420	Nucleotide excision repair	1/1110	46/7206	0.00691837657691
ko00260	Glycine, serine and threonine metabolism	1/1110	48/7206	0.00743062185845
ko05321	Inflammatory bowel disease (IBD)	2/1110	56/7206	0.0086464257734
ko04657	IL-17 signaling pathway	5/1110	87/7206	0.0101828867706
ko03022	Basal transcription factors	1/1110	44/7206	0.0104393473234
ko05144	Malaria	1/1110	45/7206	0.0108681829013
ko00071	Fatty acid degradation	1/1110	45/7206	0.0108681829013
ko00480	Glutathione metabolism	2/1110	55/7206	0.0130296014308
ko04015	Rap1 signaling pathway	58/1110	278/7206	0.0136971752287
ko03018	RNA degradation	5/1110	84/7206	0.0139684549594
ko04115	p53 signaling pathway	4/1110	74/7206	0.0141040262226
ko04918	Thyroid hormone synthesis	22/1110	86/7206	0.0149662419225
ko04217	Necroptosis	16/1110	178/7206	0.015189008436
ko04912	GnRH signaling pathway	29/1110	122/7206	0.0154209813766
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1110	40/7206	0.0154511540071
ko00140	Steroid hormone biosynthesis	1/1110	41/7206	0.0154634697751
ko05215	Prostate cancer	8/1110	111/7206	0.0161183779329
ko00380	Tryptophan metabolism	2/1110	50/7206	0.0182180200057
ko00590	Arachidonic acid metabolism	2/1110	52/7206	0.0186535175722
ko05131	Shigellosis	5/1110	82/7206	0.0195639928906
ko04622	RIG-I-like receptor signaling pathway	3/1110	62/7206	0.0198261614511
ko04214	Apoptosis - fly	4/1110	72/7206	0.0200049717209
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1110	182/7206	0.0216127980892
ko04270	Vascular smooth muscle contraction	34/1110	154/7206	0.0239710525321
ko05133	Pertussis	6/1110	87/7206	0.0243662664151
ko00562	Inositol phosphate metabolism	22/1110	89/7206	0.0251788402259
ko04922	Glucagon signaling pathway	29/1110	128/7206	0.0260311517694
ko05219	Bladder cancer	2/1110	48/7206	0.0262383455857
ko04210	Apoptosis	17/1110	180/7206	0.027385793005
ko04350	TGF-beta signaling pathway	8/1110	103/7206	0.0275879586011
ko05034	Alcoholism	49/1110	238/7206	0.028211703561
ko04973	Carbohydrate digestion and absorption	12/1110	42/7206	0.0288409215774
ko05231	Choline metabolism in cancer	30/1110	134/7206	0.029205282811
ko04114	Oocyte meiosis	31/1110	139/7206	0.0317250330262
ko05145	Toxoplasmosis	11/1110	126/7206	0.0341611141786
ko05206	MicroRNAs in cancer	17/1110	177/7206	0.0341990619802
ko00982	Drug metabolism - cytochrome P450	1/1110	37/7206	0.0357658073828
ko01524	Platinum drug resistance	5/1110	76/7206	0.0359602412485
ko05010	Alzheimer's disease	42/1110	202/7206	0.0374201733686
ko04930	Type II diabetes mellitus	14/1110	54/7206	0.037653627963
ko05418	Fluid shear stress and atherosclerosis	17/1110	173/7206	0.042171768594
ko04137	Mitophagy - animal	6/1110	82/7206	0.0441344187339
ko04916	Melanogenesis	31/1110	142/7206	0.0448106574972