ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	202/1221	423/7206	2.09799391865e-52
ko04724	Glutamatergic synapse	94/1221	152/7206	3.93750646694e-36
ko05033	Nicotine addiction	51/1221	56/7206	3.15963264715e-34
ko05032	Morphine addiction	73/1221	110/7206	3.56357469673e-31
ko04713	Circadian entrainment	79/1221	136/7206	7.67327816107e-28
ko04727	GABAergic synapse	69/1221	110/7206	2.78539125227e-27
ko04728	Dopaminergic synapse	91/1221	185/7206	1.06061045461e-24
ko04725	Cholinergic synapse	81/1221	160/7206	3.95813110879e-23
ko04024	cAMP signaling pathway	113/1221	279/7206	2.04152989752e-21
ko04723	Retrograde endocannabinoid signaling	83/1221	175/7206	2.71947646289e-21
ko04721	Synaptic vesicle cycle	50/1221	80/7206	5.63585205258e-20
ko04921	Oxytocin signaling pathway	85/1221	209/7206	1.48706168629e-16
ko04020	Calcium signaling pathway	100/1221	265/7206	1.87322747711e-16
ko04911	Insulin secretion	58/1221	117/7206	2.48250322539e-16
ko04742	Taste transduction	38/1221	61/7206	2.06972954659e-15
ko04726	Serotonergic synapse	62/1221	137/7206	5.65689126554e-15
ko04744	Phototransduction	27/1221	36/7206	2.3436472232e-14
ko05031	Amphetamine addiction	46/1221	91/7206	1.29546735367e-13
ko04261	Adrenergic signaling in cardiomyocytes	78/1221	205/7206	2.07499429559e-13
ko04720	Long-term potentiation	47/1221	99/7206	1.35884287296e-12
ko05030	Cocaine addiction	37/1221	73/7206	2.98881080165e-11
ko03040	Spliceosome	1/1221	145/7206	7.17321703484e-11
ko04360	Axon guidance	77/1221	233/7206	1.19773111993e-09
ko04971	Gastric acid secretion	41/1221	98/7206	4.4381954546e-09
ko04970	Salivary secretion	40/1221	95/7206	5.48708563955e-09
ko04925	Aldosterone synthesis and secretion	43/1221	105/7206	7.0181641422e-09
ko05322	Systemic lupus erythematosus	5/1221	151/7206	2.48298485729e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1221	74/7206	3.3112904679e-07
ko04060	Cytokine-cytokine receptor interaction	9/1221	191/7206	3.82998666078e-07
ko04022	cGMP-PKG signaling pathway	66/1221	216/7206	4.8155918785e-07
ko03013	RNA transport	7/1221	166/7206	5.75740409294e-07
ko04070	Phosphatidylinositol signaling system	41/1221	112/7206	6.10003199736e-07
ko05203	Viral carcinogenesis	19/1221	277/7206	7.33813247833e-07
ko04010	MAPK signaling pathway	89/1221	321/7206	8.61882954397e-07
ko04072	Phospholipase D signaling pathway	60/1221	197/7206	1.82486869462e-06
ko04972	Pancreatic secretion	39/1221	111/7206	2.68157682146e-06
ko04740	Olfactory transduction	31/1221	80/7206	2.82662470483e-06
ko05168	Herpes simplex infection	10/1221	182/7206	4.85484567737e-06
ko04610	Complement and coagulation cascades	1/1221	79/7206	1.26573273104e-05
ko04923	Regulation of lipolysis in adipocytes	28/1221	77/7206	4.02377020176e-05
ko04915	Estrogen signaling pathway	41/1221	131/7206	4.77646146551e-05
ko04730	Long-term depression	28/1221	78/7206	4.82375708369e-05
ko05110	Vibrio cholerae infection	24/1221	63/7206	5.47201186349e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1221	79/7206	5.90969818981e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1221	59/7206	6.05187795623e-05
ko05414	Dilated cardiomyopathy	36/1221	112/7206	6.47540059821e-05
ko04014	Ras signaling pathway	73/1221	279/7206	8.26824602182e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1221	79/7206	0.00011050059179
ko04540	Gap junction	39/1221	128/7206	0.00012206127492
ko04924	Renin secretion	29/1221	86/7206	0.000127210172209
ko04141	Protein processing in endoplasmic reticulum	13/1221	184/7206	0.000130867864767
ko04640	Hematopoietic cell lineage	1/1221	64/7206	0.000155749387404
ko04745	Phototransduction - fly	16/1221	38/7206	0.000222449057656
ko04371	Apelin signaling pathway	49/1221	177/7206	0.000334069494289
ko04966	Collecting duct acid secretion	12/1221	26/7206	0.000497058296673
ko04912	GnRH signaling pathway	36/1221	122/7206	0.000550111345728
ko04750	Inflammatory mediator regulation of TRP channels	36/1221	122/7206	0.000550111345728
ko04612	Antigen processing and presentation	3/1221	77/7206	0.0006844380352
ko05164	Influenza A	13/1221	167/7206	0.000766402651305
ko00520	Amino sugar and nucleotide sugar metabolism	1/1221	55/7206	0.000842637960105
ko04514	Cell adhesion molecules (CAMs)	37/1221	130/7206	0.000872165591922
ko04064	NF-kappa B signaling pathway	5/1221	96/7206	0.000873258131231
ko04260	Cardiac muscle contraction	30/1221	98/7206	0.000937202876409
ko04621	NOD-like receptor signaling pathway	12/1221	157/7206	0.00112217076375
ko04626	Plant-pathogen interaction	9/1221	18/7206	0.00125873661709
ko04976	Bile secretion	25/1221	80/7206	0.00142458640054
ko04110	Cell cycle	11/1221	145/7206	0.00157737916647
ko00240	Pyrimidine metabolism	7/1221	110/7206	0.001855101262
ko04146	Peroxisome	5/1221	89/7206	0.00248693212288
ko04930	Type II diabetes mellitus	18/1221	54/7206	0.00297559458095
ko05231	Choline metabolism in cancer	36/1221	134/7206	0.00343343858128
ko05321	Inflammatory bowel disease (IBD)	2/1221	56/7206	0.00376195350137
ko03022	Basal transcription factors	1/1221	44/7206	0.00428628912819
ko00071	Fatty acid degradation	1/1221	45/7206	0.0043347223828
ko05162	Measles	9/1221	120/7206	0.00437215097266
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1221	14/7206	0.00448235197245
ko03420	Nucleotide excision repair	1/1221	46/7206	0.00456461347155
ko04115	p53 signaling pathway	4/1221	74/7206	0.00469944825428
ko05140	Leishmaniasis	4/1221	75/7206	0.00475902483301
ko05205	Proteoglycans in cancer	29/1221	271/7206	0.0048350608965
ko04722	Neurotrophin signaling pathway	41/1221	160/7206	0.00527185480695
ko00515	Mannose type O-glycan biosynthesis	10/1221	25/7206	0.00527747387354
ko04918	Thyroid hormone synthesis	25/1221	86/7206	0.00535092911053
ko04015	Rap1 signaling pathway	65/1221	278/7206	0.00538796945001
ko04916	Melanogenesis	37/1221	142/7206	0.00627872988488
ko05169	Epstein-Barr virus infection	21/1221	206/7206	0.00804446044368
ko00590	Arachidonic acid metabolism	2/1221	52/7206	0.00822332275455
ko00330	Arginine and proline metabolism	3/1221	61/7206	0.00911719855459
ko03320	PPAR signaling pathway	4/1221	69/7206	0.00936910862769
ko00562	Inositol phosphate metabolism	25/1221	89/7206	0.00961080548755
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1221	40/7206	0.00976944788378
ko04062	Chemokine signaling pathway	48/1221	201/7206	0.009935635711
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1221	100/7206	0.0102909774727
ko04114	Oocyte meiosis	35/1221	139/7206	0.0118067647103
ko00260	Glycine, serine and threonine metabolism	2/1221	48/7206	0.0118390985995
ko04270	Vascular smooth muscle contraction	38/1221	154/7206	0.0123831664716
ko03018	RNA degradation	6/1221	84/7206	0.012506707098
ko04711	Circadian rhythm - fly	6/1221	13/7206	0.0136385836996
ko00982	Drug metabolism - cytochrome P450	1/1221	37/7206	0.0145278757041
ko00630	Glyoxylate and dicarboxylate metabolism	1/1221	38/7206	0.0148776720521
ko03410	Base excision repair	1/1221	38/7206	0.0148776720521
ko04120	Ubiquitin mediated proteolysis	13/1221	138/7206	0.0157193253605
ko04922	Glucagon signaling pathway	32/1221	128/7206	0.0173850143075
ko00310	Lysine degradation	5/1221	73/7206	0.0179311982425
ko05161	Hepatitis B	18/1221	173/7206	0.0181547972995
ko00480	Glutathione metabolism	3/1221	55/7206	0.0182850530183
ko04071	Sphingolipid signaling pathway	39/1221	162/7206	0.019275373796
ko04213	Longevity regulating pathway - multiple species	23/1221	86/7206	0.0200228426368
ko04964	Proximal tubule bicarbonate reclamation	10/1221	29/7206	0.0215254695489
ko00513	Various types of N-glycan biosynthesis	13/1221	42/7206	0.0220395250973
ko04622	RIG-I-like receptor signaling pathway	4/1221	62/7206	0.0257827699934
ko00280	Valine, leucine and isoleucine degradation	3/1221	54/7206	0.0267150625998
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1221	15/7206	0.0293833895685
ko05034	Alcoholism	53/1221	238/7206	0.0344365346833
ko04962	Vasopressin-regulated water reabsorption	16/1221	58/7206	0.0353606826012
ko00380	Tryptophan metabolism	3/1221	50/7206	0.0366015534959
ko04710	Circadian rhythm	13/1221	43/7206	0.0380655246702
ko04012	ErbB signaling pathway	27/1221	109/7206	0.0383499677843
ko04217	Necroptosis	20/1221	178/7206	0.0424780834113
ko05320	Autoimmune thyroid disease	1/1221	29/7206	0.0484908530525
ko05340	Primary immunodeficiency	1/1221	30/7206	0.0486349518238