ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	150/875	423/7206	3.00715417802e-38
ko04724	Glutamatergic synapse	76/875	152/7206	6.3573490984e-31
ko05033	Nicotine addiction	42/875	56/7206	1.54656057103e-27
ko04727	GABAergic synapse	54/875	110/7206	9.63751622018e-22
ko05032	Morphine addiction	54/875	110/7206	9.63751622018e-22
ko04725	Cholinergic synapse	66/875	160/7206	4.43070698714e-21
ko04713	Circadian entrainment	60/875	136/7206	4.91475617034e-21
ko04728	Dopaminergic synapse	69/875	185/7206	4.26289610883e-19
ko04723	Retrograde endocannabinoid signaling	65/875	175/7206	6.13479288354e-18
ko04721	Synaptic vesicle cycle	41/875	80/7206	1.17039614002e-17
ko04742	Taste transduction	32/875	61/7206	1.96669525791e-14
ko04024	cAMP signaling pathway	80/875	279/7206	3.10391475368e-14
ko04911	Insulin secretion	46/875	117/7206	4.25061949809e-14
ko04744	Phototransduction	23/875	36/7206	3.24145384307e-13
ko04726	Serotonergic synapse	47/875	137/7206	7.65000055676e-12
ko04921	Oxytocin signaling pathway	60/875	209/7206	8.72309296886e-11
ko05031	Amphetamine addiction	33/875	91/7206	2.10158007958e-09
ko04020	Calcium signaling pathway	66/875	265/7206	4.60624943329e-09
ko04261	Adrenergic signaling in cardiomyocytes	54/875	205/7206	2.33581392873e-08
ko04970	Salivary secretion	32/875	95/7206	2.92430458008e-08
ko05203	Viral carcinogenesis	8/875	277/7206	4.98484921026e-08
ko04720	Long-term potentiation	32/875	99/7206	8.85817538922e-08
ko05030	Cocaine addiction	26/875	73/7206	1.65062889396e-07
ko03040	Spliceosome	1/875	145/7206	2.23737284887e-07
ko04971	Gastric acid secretion	31/875	98/7206	2.43958517747e-07
ko04740	Olfactory transduction	27/875	80/7206	3.38474743492e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	25/875	74/7206	9.01578299966e-07
ko04514	Cell adhesion molecules (CAMs)	36/875	130/7206	1.0931169384e-06
ko05164	Influenza A	3/875	167/7206	1.62836653634e-06
ko04060	Cytokine-cytokine receptor interaction	5/875	191/7206	2.91689213751e-06
ko04120	Ubiquitin mediated proteolysis	2/875	138/7206	4.79027817835e-06
ko05168	Herpes simplex infection	5/875	182/7206	8.74539861243e-06
ko04925	Aldosterone synthesis and secretion	29/875	105/7206	1.34865377807e-05
ko05322	Systemic lupus erythematosus	4/875	151/7206	4.32376128899e-05
ko04972	Pancreatic secretion	29/875	111/7206	4.73346500619e-05
ko04022	cGMP-PKG signaling pathway	47/875	216/7206	4.81657894066e-05
ko05162	Measles	2/875	120/7206	5.1828636018e-05
ko03013	RNA transport	5/875	166/7206	5.37207877901e-05
ko04010	MAPK signaling pathway	63/875	321/7206	7.60965187184e-05
ko04621	NOD-like receptor signaling pathway	5/875	157/7206	0.00010555573865
ko04730	Long-term depression	22/875	78/7206	0.000135858740171
ko04976	Bile secretion	22/875	80/7206	0.000176035305496
ko04260	Cardiac muscle contraction	25/875	98/7206	0.00023866919653
ko04360	Axon guidance	47/875	233/7206	0.000332741302899
ko05166	HTLV-I infection	17/875	292/7206	0.000333524515684
ko04964	Proximal tubule bicarbonate reclamation	11/875	29/7206	0.000344739029056
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	21/875	79/7206	0.000377000376341
ko04932	Non-alcoholic fatty liver disease (NAFLD)	8/875	182/7206	0.000490648500606
ko04966	Collecting duct acid secretion	10/875	26/7206	0.000563435686039
ko04924	Renin secretion	22/875	86/7206	0.000626673510814
ko03008	Ribosome biogenesis in eukaryotes	1/875	79/7206	0.000753833008383
ko04612	Antigen processing and presentation	1/875	77/7206	0.00117330934996
ko04110	Cell cycle	6/875	145/7206	0.00122322431518
ko04745	Phototransduction - fly	12/875	38/7206	0.0012672177731
ko05161	Hepatitis B	8/875	173/7206	0.00128830016375
ko04540	Gap junction	28/875	128/7206	0.0015322462007
ko05169	Epstein-Barr virus infection	11/875	206/7206	0.00153787148161
ko05205	Proteoglycans in cancer	17/875	271/7206	0.00165468710443
ko04141	Protein processing in endoplasmic reticulum	10/875	184/7206	0.0028221700626
ko05215	Prostate cancer	4/875	111/7206	0.00301436899761
ko04064	NF-kappa B signaling pathway	3/875	96/7206	0.00397825363363
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/875	14/7206	0.00398860114129
ko04961	Endocrine and other factor-regulated calcium reabsorption	15/875	59/7206	0.00419907305228
ko04610	Complement and coagulation cascades	2/875	79/7206	0.00481744219436
ko04140	Autophagy - animal	9/875	164/7206	0.00530505325037
ko04014	Ras signaling pathway	49/875	279/7206	0.00656628099988
ko05140	Leishmaniasis	2/875	75/7206	0.00688688520818
ko04750	Inflammatory mediator regulation of TRP channels	25/875	122/7206	0.00740993511457
ko04146	Peroxisome	3/875	89/7206	0.00795825060761
ko05110	Vibrio cholerae infection	15/875	63/7206	0.00990165610356
ko04214	Apoptosis - fly	2/875	72/7206	0.00997646918938
ko00310	Lysine degradation	2/875	73/7206	0.0102227207828
ko04072	Phospholipase D signaling pathway	36/875	197/7206	0.010648760062
ko03018	RNA degradation	3/875	84/7206	0.0109406827264
ko04668	TNF signaling pathway	6/875	120/7206	0.0110508193671
ko00520	Amino sugar and nucleotide sugar metabolism	1/875	55/7206	0.0117600845766
ko00480	Glutathione metabolism	1/875	55/7206	0.0117600845766
ko05414	Dilated cardiomyopathy	23/875	112/7206	0.0120754452894
ko04630	Jak-STAT signaling pathway	7/875	132/7206	0.0145139249178
ko04550	Signaling pathways regulating pluripotency of stem cells	10/875	165/7206	0.0151169341839
ko04974	Protein digestion and absorption	20/875	96/7206	0.0167454236323
ko00590	Arachidonic acid metabolism	1/875	52/7206	0.0173986409018
ko05418	Fluid shear stress and atherosclerosis	11/875	173/7206	0.0177262410413
ko00280	Valine, leucine and isoleucine degradation	1/875	54/7206	0.0184856470276
ko05016	Huntington's disease	15/875	215/7206	0.019042693767
ko04640	Hematopoietic cell lineage	2/875	64/7206	0.0203008996055
ko04350	TGF-beta signaling pathway	5/875	103/7206	0.0213551709549
ko01524	Platinum drug resistance	3/875	76/7206	0.0215382233801
ko05206	MicroRNAs in cancer	12/875	177/7206	0.0261976812003
ko04218	Cellular senescence	12/875	177/7206	0.0261976812003
ko00240	Pyrimidine metabolism	6/875	110/7206	0.026878693079
ko00330	Arginine and proline metabolism	2/875	61/7206	0.0290331093745
ko05220	Chronic myeloid leukemia	4/875	85/7206	0.0296969240639
ko04150	mTOR signaling pathway	13/875	184/7206	0.0297416521463
ko04657	IL-17 signaling pathway	4/875	87/7206	0.03009838642
ko05133	Pertussis	4/875	87/7206	0.03009838642
ko04973	Carbohydrate digestion and absorption	10/875	42/7206	0.0301063499662
ko00561	Glycerolipid metabolism	2/875	63/7206	0.0301794274084
ko04115	p53 signaling pathway	3/875	74/7206	0.0302419649447
ko04371	Apelin signaling pathway	31/875	177/7206	0.0350270202175
ko03022	Basal transcription factors	1/875	44/7206	0.0373798909413
ko05144	Malaria	1/875	45/7206	0.0374527961341
ko00071	Fatty acid degradation	1/875	45/7206	0.0374527961341
ko04210	Apoptosis	13/875	180/7206	0.0376362890271
ko03420	Nucleotide excision repair	1/875	46/7206	0.038108344314
ko01200	Carbon metabolism	8/875	128/7206	0.039673511825
ko04137	Mitophagy - animal	4/875	82/7206	0.0405990059737
ko04915	Estrogen signaling pathway	24/875	131/7206	0.0412969484911
ko05410	Hypertrophic cardiomyopathy (HCM)	19/875	100/7206	0.0436647644328
ko04933	AGE-RAGE signaling pathway in diabetic complications	9/875	135/7206	0.046298504876
ko04217	Necroptosis	13/875	178/7206	0.0475022025747