ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	185/1136	423/7206	9.42651206058e-46
ko04724	Glutamatergic synapse	90/1136	152/7206	4.59733223441e-35
ko05033	Nicotine addiction	50/1136	56/7206	3.75445597217e-34
ko05032	Morphine addiction	69/1136	110/7206	2.91629468021e-29
ko04727	GABAergic synapse	67/1136	110/7206	2.43467424756e-27
ko04713	Circadian entrainment	73/1136	136/7206	6.50395887302e-25
ko04728	Dopaminergic synapse	84/1136	185/7206	4.04497481324e-22
ko04721	Synaptic vesicle cycle	49/1136	80/7206	1.92832650132e-20
ko04723	Retrograde endocannabinoid signaling	78/1136	175/7206	5.33221948846e-20
ko04725	Cholinergic synapse	73/1136	160/7206	1.6821787789e-19
ko04024	cAMP signaling pathway	97/1136	279/7206	1.4992332126e-15
ko04911	Insulin secretion	53/1136	117/7206	2.55862470461e-14
ko04744	Phototransduction	26/1136	36/7206	5.49175696587e-14
ko04742	Taste transduction	35/1136	61/7206	9.67334517409e-14
ko04921	Oxytocin signaling pathway	75/1136	209/7206	5.35466603019e-13
ko04726	Serotonergic synapse	56/1136	137/7206	9.57260448382e-13
ko04020	Calcium signaling pathway	86/1136	265/7206	6.05923471429e-12
ko04261	Adrenergic signaling in cardiomyocytes	71/1136	205/7206	1.57111271357e-11
ko05031	Amphetamine addiction	40/1136	91/7206	1.26145231161e-10
ko04720	Long-term potentiation	42/1136	99/7206	1.71606095971e-10
ko03040	Spliceosome	1/1136	145/7206	5.18440035438e-10
ko04740	Olfactory transduction	34/1136	80/7206	9.02933681426e-09
ko05030	Cocaine addiction	32/1136	73/7206	9.90279668491e-09
ko05203	Viral carcinogenesis	14/1136	277/7206	2.94163222304e-08
ko04925	Aldosterone synthesis and secretion	40/1136	105/7206	3.27795849506e-08
ko04970	Salivary secretion	36/1136	95/7206	1.92684816623e-07
ko04010	MAPK signaling pathway	85/1136	321/7206	4.27746929102e-07
ko03013	RNA transport	6/1136	166/7206	7.97016130959e-07
ko04360	Axon guidance	66/1136	233/7206	8.74950627156e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1136	74/7206	8.8695317612e-07
ko04971	Gastric acid secretion	35/1136	98/7206	9.76863446915e-07
ko05322	Systemic lupus erythematosus	5/1136	151/7206	1.3390210635e-06
ko05168	Herpes simplex infection	8/1136	182/7206	2.36673389695e-06
ko04060	Cytokine-cytokine receptor interaction	10/1136	191/7206	7.69266943707e-06
ko04972	Pancreatic secretion	36/1136	111/7206	9.69028705593e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1136	59/7206	1.32166940514e-05
ko05164	Influenza A	8/1136	167/7206	1.32639677872e-05
ko04730	Long-term depression	27/1136	78/7206	3.24083823633e-05
ko04514	Cell adhesion molecules (CAMs)	39/1136	130/7206	4.34201850517e-05
ko04621	NOD-like receptor signaling pathway	8/1136	157/7206	5.28448585066e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1136	79/7206	5.92865831812e-05
ko04072	Phospholipase D signaling pathway	53/1136	197/7206	5.96914383182e-05
ko04141	Protein processing in endoplasmic reticulum	11/1136	184/7206	8.04986175253e-05
ko04022	cGMP-PKG signaling pathway	56/1136	216/7206	8.99460609351e-05
ko04260	Cardiac muscle contraction	30/1136	98/7206	0.000210562375366
ko03008	Ribosome biogenesis in eukaryotes	2/1136	79/7206	0.000265845116561
ko05162	Measles	6/1136	120/7206	0.000358731571847
ko04612	Antigen processing and presentation	2/1136	77/7206	0.000400323179975
ko05205	Proteoglycans in cancer	23/1136	271/7206	0.000460441872698
ko04976	Bile secretion	25/1136	80/7206	0.000511212253098
ko04120	Ubiquitin mediated proteolysis	8/1136	138/7206	0.000538356996952
ko05414	Dilated cardiomyopathy	32/1136	112/7206	0.000556461581734
ko04915	Estrogen signaling pathway	36/1136	131/7206	0.000595025516104
ko04064	NF-kappa B signaling pathway	4/1136	96/7206	0.000599752852305
ko05140	Leishmaniasis	2/1136	75/7206	0.000609202382745
ko03018	RNA degradation	3/1136	84/7206	0.000744846949237
ko04966	Collecting duct acid secretion	11/1136	26/7206	0.00111123340898
ko04745	Phototransduction - fly	14/1136	38/7206	0.00125519914248
ko00480	Glutathione metabolism	1/1136	55/7206	0.00134166860019
ko04540	Gap junction	34/1136	128/7206	0.0013854218382
ko05110	Vibrio cholerae infection	20/1136	63/7206	0.00139027379055
ko04070	Phosphatidylinositol signaling system	31/1136	112/7206	0.00146362601584
ko04110	Cell cycle	10/1136	145/7206	0.00175720136033
ko04146	Peroxisome	4/1136	89/7206	0.00178862856721
ko04640	Hematopoietic cell lineage	2/1136	64/7206	0.00279656131716
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1136	14/7206	0.00293426203693
ko04371	Apelin signaling pathway	43/1136	177/7206	0.00321276556056
ko04214	Apoptosis - fly	3/1136	72/7206	0.00323004781505
ko00590	Arachidonic acid metabolism	1/1136	52/7206	0.00323281640538
ko05169	Epstein-Barr virus infection	18/1136	206/7206	0.00351500036321
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1136	182/7206	0.00369912071994
ko05161	Hepatitis B	14/1136	173/7206	0.00408881352065
ko04924	Renin secretion	24/1136	86/7206	0.00409703255426
ko04014	Ras signaling pathway	62/1136	279/7206	0.00421485636847
ko00260	Glycine, serine and threonine metabolism	1/1136	48/7206	0.00456571703868
ko04217	Necroptosis	15/1136	178/7206	0.00477112647695
ko00240	Pyrimidine metabolism	7/1136	110/7206	0.00511315665803
ko04750	Inflammatory mediator regulation of TRP channels	31/1136	122/7206	0.00545446385363
ko05145	Toxoplasmosis	9/1136	126/7206	0.00618070853635
ko05144	Malaria	1/1136	45/7206	0.00680771908227
ko03420	Nucleotide excision repair	1/1136	46/7206	0.00696206693853
ko04657	IL-17 signaling pathway	5/1136	87/7206	0.0071434945846
ko05321	Inflammatory bowel disease (IBD)	2/1136	56/7206	0.00870351207678
ko04115	p53 signaling pathway	4/1136	74/7206	0.00984440086597
ko01200	Carbon metabolism	10/1136	128/7206	0.00992508478411
ko03022	Basal transcription factors	1/1136	44/7206	0.0107190990225
ko04622	RIG-I-like receptor signaling pathway	3/1136	62/7206	0.0134677959899
ko04137	Mitophagy - animal	5/1136	82/7206	0.0137550200748
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1136	40/7206	0.0152387909334
ko00140	Steroid hormone biosynthesis	1/1136	41/7206	0.0156876235762
ko04918	Thyroid hormone synthesis	22/1136	86/7206	0.0166452549746
ko04210	Apoptosis	17/1136	180/7206	0.0168838035991
ko04964	Proximal tubule bicarbonate reclamation	10/1136	29/7206	0.0172051281246
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1136	100/7206	0.017705984509
ko05133	Pertussis	6/1136	87/7206	0.0178171355994
ko04923	Regulation of lipolysis in adipocytes	20/1136	77/7206	0.018018461931
ko00330	Arginine and proline metabolism	3/1136	61/7206	0.0198673540969
ko04218	Cellular senescence	17/1136	177/7206	0.021280514099
ko05166	HTLV-I infection	32/1136	292/7206	0.0214163833471
ko00982	Drug metabolism - cytochrome P450	1/1136	37/7206	0.0226401881323
ko04658	Th1 and Th2 cell differentiation	7/1136	96/7206	0.022852670272
ko00630	Glyoxylate and dicarboxylate metabolism	1/1136	38/7206	0.0230377572126
ko04912	GnRH signaling pathway	29/1136	122/7206	0.0230944633296
ko04270	Vascular smooth muscle contraction	35/1136	154/7206	0.024570120783
ko00270	Cysteine and methionine metabolism	2/1136	47/7206	0.0259511999312
ko04140	Autophagy - animal	16/1136	164/7206	0.0301841485189
ko00513	Various types of N-glycan biosynthesis	12/1136	42/7206	0.0316304263246
ko05131	Shigellosis	6/1136	82/7206	0.0324121064823
ko00640	Propanoate metabolism	1/1136	34/7206	0.0336877315587
ko05418	Fluid shear stress and atherosclerosis	17/1136	173/7206	0.0338891893034
ko04015	Rap1 signaling pathway	57/1136	278/7206	0.0353842849385
ko04620	Toll-like receptor signaling pathway	8/1136	100/7206	0.0367465096944
ko00071	Fatty acid degradation	2/1136	45/7206	0.0377576857273
ko00280	Valine, leucine and isoleucine degradation	3/1136	54/7206	0.0379528475971
ko00620	Pyruvate metabolism	2/1136	46/7206	0.0390208426225
ko05222	Small cell lung cancer	7/1136	89/7206	0.0396910784789
ko04668	TNF signaling pathway	11/1136	120/7206	0.0434221792955
ko05034	Alcoholism	49/1136	238/7206	0.0460163714492
ko00515	Mannose type O-glycan biosynthesis	8/1136	25/7206	0.0467156376001
ko04062	Chemokine signaling pathway	42/1136	201/7206	0.049180931048