ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	195/1181	423/7206	6.32917670749e-50
ko04724	Glutamatergic synapse	95/1181	152/7206	2.45848958916e-38
ko05033	Nicotine addiction	50/1181	56/7206	2.61549474878e-33
ko05032	Morphine addiction	72/1181	110/7206	3.85570459238e-31
ko04713	Circadian entrainment	81/1181	136/7206	1.22139543256e-30
ko04727	GABAergic synapse	70/1181	110/7206	3.70495760164e-29
ko04725	Cholinergic synapse	81/1181	160/7206	4.08206371127e-24
ko04728	Dopaminergic synapse	87/1181	185/7206	5.54557441439e-23
ko04723	Retrograde endocannabinoid signaling	81/1181	175/7206	6.53127662376e-21
ko04721	Synaptic vesicle cycle	49/1181	80/7206	1.075808432e-19
ko04911	Insulin secretion	61/1181	117/7206	2.95904459687e-19
ko04024	cAMP signaling pathway	105/1181	279/7206	2.08986926691e-18
ko04020	Calcium signaling pathway	99/1181	265/7206	6.22109820042e-17
ko04921	Oxytocin signaling pathway	83/1181	209/7206	2.57292746635e-16
ko04726	Serotonergic synapse	61/1181	137/7206	4.85082554115e-15
ko04744	Phototransduction	27/1181	36/7206	9.99800702105e-15
ko04261	Adrenergic signaling in cardiomyocytes	78/1181	205/7206	3.2952648148e-14
ko04742	Taste transduction	36/1181	61/7206	4.3565678272e-14
ko04720	Long-term potentiation	48/1181	99/7206	7.8531440891e-14
ko05031	Amphetamine addiction	45/1181	91/7206	1.93422746186e-13
ko04970	Salivary secretion	43/1181	95/7206	2.86723741148e-11
ko03040	Spliceosome	1/1181	145/7206	1.92696493823e-10
ko04740	Olfactory transduction	37/1181	80/7206	3.26188341506e-10
ko04925	Aldosterone synthesis and secretion	44/1181	105/7206	3.76983134939e-10
ko04971	Gastric acid secretion	42/1181	98/7206	4.08394394781e-10
ko04360	Axon guidance	75/1181	233/7206	1.3580796737e-09
ko05030	Cocaine addiction	34/1181	73/7206	1.35981135145e-09
ko04010	MAPK signaling pathway	88/1181	321/7206	3.98622277616e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1181	74/7206	5.70997778757e-07
ko05322	Systemic lupus erythematosus	5/1181	151/7206	5.8109071876e-07
ko05168	Herpes simplex infection	8/1181	182/7206	7.27761649298e-07
ko04060	Cytokine-cytokine receptor interaction	9/1181	191/7206	8.2227089629e-07
ko04972	Pancreatic secretion	39/1181	111/7206	1.55057506203e-06
ko04745	Phototransduction - fly	19/1181	38/7206	1.58829774369e-06
ko04070	Phosphatidylinositol signaling system	39/1181	112/7206	1.7730765065e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	25/1181	59/7206	1.89263162662e-06
ko03013	RNA transport	7/1181	166/7206	1.93998914114e-06
ko04022	cGMP-PKG signaling pathway	63/1181	216/7206	2.18081984918e-06
ko05203	Viral carcinogenesis	20/1181	277/7206	6.45820113757e-06
ko04141	Protein processing in endoplasmic reticulum	10/1181	184/7206	7.19029007065e-06
ko04730	Long-term depression	29/1181	78/7206	7.74980286852e-06
ko04072	Phospholipase D signaling pathway	57/1181	197/7206	8.41040220434e-06
ko04540	Gap junction	40/1181	128/7206	2.91749396766e-05
ko05414	Dilated cardiomyopathy	36/1181	112/7206	2.93581927652e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1181	79/7206	3.91631569475e-05
ko04621	NOD-like receptor signaling pathway	9/1181	157/7206	7.23278893765e-05
ko05110	Vibrio cholerae infection	23/1181	63/7206	9.70789814664e-05
ko04915	Estrogen signaling pathway	39/1181	131/7206	0.000110285990651
ko04014	Ras signaling pathway	70/1181	279/7206	0.000137701879406
ko04260	Cardiac muscle contraction	31/1181	98/7206	0.000159272819026
ko03008	Ribosome biogenesis in eukaryotes	2/1181	79/7206	0.000172118846938
ko04924	Renin secretion	28/1181	86/7206	0.000186534540141
ko05164	Influenza A	11/1181	167/7206	0.000191258512179
ko04640	Hematopoietic cell lineage	1/1181	64/7206	0.000249570692728
ko04612	Antigen processing and presentation	2/1181	77/7206	0.00026160097386
ko04371	Apelin signaling pathway	48/1181	177/7206	0.000276148385402
ko04750	Inflammatory mediator regulation of TRP channels	36/1181	122/7206	0.000278889059836
ko04976	Bile secretion	26/1181	80/7206	0.000352444291879
ko04923	Regulation of lipolysis in adipocytes	25/1181	77/7206	0.000488694903504
ko04912	GnRH signaling pathway	35/1181	122/7206	0.00073204891952
ko04110	Cell cycle	10/1181	145/7206	0.000925815699302
ko04514	Cell adhesion molecules (CAMs)	36/1181	130/7206	0.00108951911803
ko04064	NF-kappa B signaling pathway	5/1181	96/7206	0.00127838341068
ko04966	Collecting duct acid secretion	11/1181	26/7206	0.00154669851832
ko00590	Arachidonic acid metabolism	1/1181	52/7206	0.00200800049818
ko04120	Ubiquitin mediated proteolysis	10/1181	138/7206	0.00231512075599
ko04916	Melanogenesis	37/1181	142/7206	0.00278173277403
ko00260	Glycine, serine and threonine metabolism	1/1181	48/7206	0.00293040815942
ko04918	Thyroid hormone synthesis	25/1181	86/7206	0.00297179953877
ko04146	Peroxisome	5/1181	89/7206	0.00357104701752
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1181	14/7206	0.00368924691377
ko03420	Nucleotide excision repair	1/1181	46/7206	0.00441168421393
ko04960	Aldosterone-regulated sodium reabsorption	14/1181	41/7206	0.00479853716468
ko04062	Chemokine signaling pathway	48/1181	201/7206	0.00499261655025
ko00480	Glutathione metabolism	2/1181	55/7206	0.00567482005004
ko05321	Inflammatory bowel disease (IBD)	2/1181	56/7206	0.00572201288308
ko04973	Carbohydrate digestion and absorption	14/1181	42/7206	0.00585326363979
ko05162	Measles	9/1181	120/7206	0.00589947711168
ko04015	Rap1 signaling pathway	63/1181	278/7206	0.0061895185398
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1181	100/7206	0.00619783151428
ko00240	Pyrimidine metabolism	8/1181	110/7206	0.00627017923909
ko03022	Basal transcription factors	1/1181	44/7206	0.00669944817098
ko04115	p53 signaling pathway	4/1181	74/7206	0.00681976375542
ko05140	Leishmaniasis	4/1181	75/7206	0.00691913853726
ko03018	RNA degradation	5/1181	84/7206	0.00697909883864
ko00071	Fatty acid degradation	1/1181	45/7206	0.00703342868811
ko04213	Longevity regulating pathway - multiple species	24/1181	86/7206	0.00751510994997
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1181	182/7206	0.00806515809604
ko04622	RIG-I-like receptor signaling pathway	3/1181	62/7206	0.00920939733432
ko00310	Lysine degradation	4/1181	73/7206	0.00991632007746
ko04217	Necroptosis	17/1181	178/7206	0.0102537771086
ko04922	Glucagon signaling pathway	32/1181	128/7206	0.0110651668362
ko05169	Epstein-Barr virus infection	21/1181	206/7206	0.012882221716
ko03320	PPAR signaling pathway	4/1181	69/7206	0.0134694388374
ko00330	Arginine and proline metabolism	3/1181	61/7206	0.0135402233103
ko04114	Oocyte meiosis	34/1181	139/7206	0.0144563580913
ko04930	Type II diabetes mellitus	16/1181	54/7206	0.0147337254803
ko00630	Glyoxylate and dicarboxylate metabolism	1/1181	38/7206	0.0148384269172
ko04270	Vascular smooth muscle contraction	37/1181	154/7206	0.0148718436653
ko05205	Proteoglycans in cancer	30/1181	271/7206	0.0150556615542
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1181	40/7206	0.0157852032913
ko05202	Transcriptional misregulation in cancer	19/1181	188/7206	0.0163948592711
ko05161	Hepatitis B	17/1181	173/7206	0.016525318798
ko04722	Neurotrophin signaling pathway	38/1181	160/7206	0.0168697422084
ko04210	Apoptosis	18/1181	180/7206	0.0185651863588
ko04626	Plant-pathogen interaction	7/1181	18/7206	0.018776813907
ko00513	Various types of N-glycan biosynthesis	13/1181	42/7206	0.0188738222014
ko04964	Proximal tubule bicarbonate reclamation	10/1181	29/7206	0.0190642539034
ko05214	Glioma	21/1181	79/7206	0.020674426029
ko00982	Drug metabolism - cytochrome P450	1/1181	37/7206	0.0229510964485
ko05016	Huntington's disease	23/1181	215/7206	0.0242501479526
ko04214	Apoptosis - fly	5/1181	72/7206	0.0250702480092
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1181	15/7206	0.0252385494668
ko04012	ErbB signaling pathway	27/1181	109/7206	0.0255522610987
ko01200	Carbon metabolism	12/1181	128/7206	0.029649468976
ko04975	Fat digestion and absorption	1/1181	35/7206	0.0351584741646
ko05145	Toxoplasmosis	12/1181	126/7206	0.0381508371089
ko04919	Thyroid hormone signaling pathway	33/1181	143/7206	0.0390243780133
ko04657	IL-17 signaling pathway	7/1181	87/7206	0.0397543454129
ko05133	Pertussis	7/1181	87/7206	0.0397543454129
ko05034	Alcoholism	51/1181	238/7206	0.0400370283244
ko00562	Inositol phosphate metabolism	22/1181	89/7206	0.0423675973773
ko00512	Mucin type O-glycan biosynthesis	9/1181	29/7206	0.0427468006024
ko05231	Choline metabolism in cancer	31/1181	134/7206	0.0441513225036
ko04711	Circadian rhythm - fly	5/1181	13/7206	0.0478569905119
ko05340	Primary immunodeficiency	1/1181	30/7206	0.0492049652707