ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 31/334 134/7206 3.65813811336e-14 ko04060 Cytokine-cytokine receptor interaction 37/334 191/7206 4.43527959618e-14 ko04650 Natural killer cell mediated cytotoxicity 26/334 97/7206 1.11426880898e-13 ko04621 NOD-like receptor signaling pathway 31/334 157/7206 3.40585848747e-12 ko05340 Primary immunodeficiency 14/334 30/7206 1.19763898097e-11 ko04064 NF-kappa B signaling pathway 23/334 96/7206 3.84892935612e-11 ko05164 Influenza A 30/334 167/7206 9.39544125809e-11 ko04620 Toll-like receptor signaling pathway 23/334 100/7206 9.40792824284e-11 ko05152 Tuberculosis 31/334 187/7206 3.718881749e-10 ko05140 Leishmaniasis 19/334 75/7206 7.27158949537e-10 ko05162 Measles 24/334 120/7206 7.96895826466e-10 ko04660 T cell receptor signaling pathway 24/334 124/7206 1.60823649834e-09 ko05145 Toxoplasmosis 23/334 126/7206 1.15967845025e-08 ko05150 Staphylococcus aureus infection 12/334 36/7206 3.70001985405e-08 ko04217 Necroptosis 27/334 178/7206 3.81350714416e-08 ko05321 Inflammatory bowel disease (IBD) 14/334 56/7206 1.59094826358e-07 ko05167 Kaposi's sarcoma-associated herpesvirus infection 27/334 191/7206 1.70727385304e-07 ko05168 Herpes simplex infection 26/334 182/7206 2.3577027568e-07 ko04659 Th17 cell differentiation 19/334 106/7206 3.03102638958e-07 ko05320 Autoimmune thyroid disease 10/334 29/7206 3.64543302516e-07 ko04662 B cell receptor signaling pathway 17/334 88/7206 4.24704752833e-07 ko04610 Complement and coagulation cascades 16/334 79/7206 4.75742780531e-07 ko05330 Allograft rejection 9/334 24/7206 6.25447621863e-07 ko05161 Hepatitis B 24/334 173/7206 1.20006043525e-06 ko04612 Antigen processing and presentation 15/334 77/7206 1.83823985781e-06 ko05133 Pertussis 16/334 87/7206 1.86157908143e-06 ko05144 Malaria 11/334 45/7206 4.42210720848e-06 ko04062 Chemokine signaling pathway 25/334 201/7206 5.45461044031e-06 ko04658 Th1 and Th2 cell differentiation 16/334 96/7206 7.109444556e-06 ko05332 Graft-versus-host disease 7/334 18/7206 8.82463181731e-06 ko04630 Jak-STAT signaling pathway 19/334 132/7206 9.24935402551e-06 ko05323 Rheumatoid arthritis 15/334 89/7206 1.19746525251e-05 ko04623 Cytosolic DNA-sensing pathway 10/334 41/7206 1.23969026974e-05 ko04611 Platelet activation 21/334 163/7206 1.82112016678e-05 ko04622 RIG-I-like receptor signaling pathway 12/334 62/7206 2.1456870457e-05 ko04210 Apoptosis 22/334 180/7206 2.66432544947e-05 ko05142 Chagas disease (American trypanosomiasis) 18/334 130/7206 2.73366177279e-05 ko04668 TNF signaling pathway 17/334 120/7206 3.38661275146e-05 ko04672 Intestinal immune network for IgA production 9/334 37/7206 3.48344597907e-05 ko04145 Phagosome 19/334 162/7206 0.000164779981362 ko04664 Fc epsilon RI signaling pathway 12/334 77/7206 0.000195111668963 ko04670 Leukocyte transendothelial migration 18/334 151/7206 0.000198835684057 ko04940 Type I diabetes mellitus 7/334 32/7206 0.000532112677442 ko05134 Legionellosis 11/334 74/7206 0.000545552118032 ko04640 Hematopoietic cell lineage 10/334 64/7206 0.000648053073544 ko05160 Hepatitis C 17/334 153/7206 0.000681255804495 ko05310 Asthma 5/334 17/7206 0.000809545259013 ko04666 Fc gamma R-mediated phagocytosis 14/334 122/7206 0.00146064685788 ko05034 Alcoholism 2/334 238/7206 0.00149104680514 ko05132 Salmonella infection 12/334 98/7206 0.00180177005081 ko04728 Dopaminergic synapse 1/334 185/7206 0.00229370603622 ko05131 Shigellosis 10/334 82/7206 0.00437881401199 ko05224 Breast cancer 1/334 174/7206 0.00507220315947 ko04723 Retrograde endocannabinoid signaling 1/334 175/7206 0.00515035004555 ko04933 AGE-RAGE signaling pathway in diabetic complications 14/334 135/7206 0.00533715625982 ko05418 Fluid shear stress and atherosclerosis 16/334 173/7206 0.00867024897434 ko04514 Cell adhesion molecules (CAMs) 13/334 130/7206 0.00900653551562 ko03050 Proteasome 7/334 54/7206 0.0117088216803 ko00120 Primary bile acid biosynthesis 4/334 20/7206 0.0121780709512 ko05416 Viral myocarditis 7/334 55/7206 0.0128997828309 ko04110 Cell cycle 1/334 145/7206 0.0149742101084 ko04657 IL-17 signaling pathway 9/334 87/7206 0.018855677372 ko05146 Amoebiasis 10/334 99/7206 0.0247976389678 ko04550 Signaling pathways regulating pluripotency of stem cells 2/334 165/7206 0.0360807666122 ko05020 Prion diseases 5/334 40/7206 0.0360982059568 ko04911 Insulin secretion 1/334 117/7206 0.0444977984312 ko05166 HTLV-I infection 21/334 292/7206 0.0448742098638 ko05016 Huntington's disease 4/334 215/7206 0.0472253944643 ko04724 Glutamatergic synapse 2/334 152/7206 0.0488238146127