ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 34/326 134/7206 4.41843460348e-17 ko04064 NF-kappa B signaling pathway 27/326 96/7206 5.41943060811e-15 ko04621 NOD-like receptor signaling pathway 34/326 157/7206 7.81764831425e-15 ko04060 Cytokine-cytokine receptor interaction 37/326 191/7206 2.04397473195e-14 ko05164 Influenza A 34/326 167/7206 5.43906692079e-14 ko05140 Leishmaniasis 21/326 75/7206 6.99356597961e-12 ko05145 Toxoplasmosis 26/326 126/7206 4.24796808559e-11 ko05162 Measles 25/326 120/7206 8.206987244e-11 ko05152 Tuberculosis 31/326 187/7206 2.01673482968e-10 ko05168 Herpes simplex infection 30/326 182/7206 4.64191686619e-10 ko04217 Necroptosis 29/326 178/7206 1.22131298856e-09 ko05321 Inflammatory bowel disease (IBD) 16/326 56/7206 1.71190829274e-09 ko04620 Toll-like receptor signaling pathway 21/326 100/7206 2.40802795107e-09 ko05340 Primary immunodeficiency 12/326 30/7206 2.49543027665e-09 ko04668 TNF signaling pathway 23/326 120/7206 2.71809272007e-09 ko04660 T cell receptor signaling pathway 23/326 124/7206 5.29102884173e-09 ko05161 Hepatitis B 27/326 173/7206 1.22145195894e-08 ko04672 Intestinal immune network for IgA production 12/326 37/7206 4.01109724677e-08 ko05133 Pertussis 18/326 87/7206 4.39879237961e-08 ko04650 Natural killer cell mediated cytotoxicity 19/326 97/7206 4.70935528193e-08 ko04630 Jak-STAT signaling pathway 22/326 132/7206 8.69266271092e-08 ko04659 Th17 cell differentiation 19/326 106/7206 2.07635836858e-07 ko04658 Th1 and Th2 cell differentiation 18/326 96/7206 2.15418007821e-07 ko05150 Staphylococcus aureus infection 11/326 36/7206 2.98536319477e-07 ko05323 Rheumatoid arthritis 17/326 89/7206 3.56672633234e-07 ko05144 Malaria 12/326 45/7206 4.48755744146e-07 ko04610 Complement and coagulation cascades 15/326 79/7206 1.90746331519e-06 ko04622 RIG-I-like receptor signaling pathway 13/326 62/7206 2.91960787836e-06 ko05160 Hepatitis C 21/326 153/7206 4.59845888403e-06 ko05142 Chagas disease (American trypanosomiasis) 19/326 130/7206 5.18176925126e-06 ko05330 Allograft rejection 8/326 24/7206 6.27090728638e-06 ko04612 Antigen processing and presentation 14/326 77/7206 7.18054933771e-06 ko05332 Graft-versus-host disease 7/326 18/7206 7.51830324845e-06 ko04623 Cytosolic DNA-sensing pathway 10/326 41/7206 1.00137707853e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 23/326 191/7206 1.50487515089e-05 ko05132 Salmonella infection 15/326 98/7206 2.95625318794e-05 ko05320 Autoimmune thyroid disease 8/326 29/7206 2.99995505772e-05 ko04662 B cell receptor signaling pathway 14/326 88/7206 3.50026722836e-05 ko04210 Apoptosis 21/326 180/7206 5.70617693382e-05 ko05310 Asthma 6/326 17/7206 6.63233153799e-05 ko05131 Shigellosis 13/326 82/7206 6.91332607986e-05 ko04062 Chemokine signaling pathway 22/326 201/7206 0.000100258127871 ko05134 Legionellosis 12/326 74/7206 0.000104847440531 ko04933 AGE-RAGE signaling pathway in diabetic complications 17/326 135/7206 0.000113645044818 ko04657 IL-17 signaling pathway 13/326 87/7206 0.000129285699725 ko04940 Type I diabetes mellitus 7/326 32/7206 0.000459657069523 ko04664 Fc epsilon RI signaling pathway 10/326 77/7206 0.00230724648589 ko05169 Epstein-Barr virus infection 19/326 206/7206 0.00308197395214 ko04145 Phagosome 16/326 162/7206 0.00311856948129 ko04666 Fc gamma R-mediated phagocytosis 13/326 122/7206 0.00334402906663 ko04670 Leukocyte transendothelial migration 15/326 151/7206 0.00418132679589 ko05120 Epithelial cell signaling in Helicobacter pylori infection 10/326 92/7206 0.00835248283413 ko05166 HTLV-I infection 23/326 292/7206 0.00889134282557 ko05034 Alcoholism 3/326 238/7206 0.0100262174644 ko04080 Neuroactive ligand-receptor interaction 9/326 423/7206 0.0109935611041 ko04611 Platelet activation 15/326 163/7206 0.011098784159 ko05416 Viral myocarditis 7/326 55/7206 0.0113911161358 ko05143 African trypanosomiasis 5/326 32/7206 0.013527107697 ko05146 Amoebiasis 10/326 99/7206 0.0136812190495 ko04724 Glutamatergic synapse 1/326 152/7206 0.0155169944509 ko04917 Prolactin signaling pathway 9/326 87/7206 0.016346991563 ko04514 Cell adhesion molecules (CAMs) 12/326 130/7206 0.0166683626112 ko04310 Wnt signaling pathway 2/326 181/7206 0.017632966282 ko04728 Dopaminergic synapse 2/326 185/7206 0.0179732656602 ko05016 Huntington's disease 3/326 215/7206 0.018852566549 ko04713 Circadian entrainment 1/326 136/7206 0.021499183979 ko04072 Phospholipase D signaling pathway 16/326 197/7206 0.0219162854122 ko05130 Pathogenic Escherichia coli infection 8/326 77/7206 0.0224277860603 ko04640 Hematopoietic cell lineage 7/326 64/7206 0.0247334575959 ko00190 Oxidative phosphorylation 1/326 127/7206 0.0309882295511 ko01523 Antifolate resistance 4/326 30/7206 0.0445690318204 ko04932 Non-alcoholic fatty liver disease (NAFLD) 14/326 182/7206 0.0455227508906 ko04142 Lysosome 12/326 151/7206 0.0475742605534 ko04115 p53 signaling pathway 7/326 74/7206 0.0490757222097