ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 27/367 80/7206 6.20247143321e-16 ko04724 Glutamatergic synapse 35/367 152/7206 1.59911356228e-14 ko05033 Nicotine addiction 20/367 56/7206 1.20468375422e-12 ko04723 Retrograde endocannabinoid signaling 33/367 175/7206 3.38210345919e-11 ko04727 GABAergic synapse 25/367 110/7206 1.42951481762e-10 ko04728 Dopaminergic synapse 33/367 185/7206 1.59557518652e-10 ko04514 Cell adhesion molecules (CAMs) 26/367 130/7206 1.19767427409e-09 ko04911 Insulin secretion 24/367 117/7206 3.11363251843e-09 ko05032 Morphine addiction 23/367 110/7206 4.53211468496e-09 ko04080 Neuroactive ligand-receptor interaction 50/367 423/7206 1.50175125767e-08 ko04725 Cholinergic synapse 27/367 160/7206 2.73107288644e-08 ko04713 Circadian entrainment 24/367 136/7206 6.86766508466e-08 ko04261 Adrenergic signaling in cardiomyocytes 28/367 205/7206 1.43383030502e-06 ko04024 cAMP signaling pathway 34/367 279/7206 1.90096534846e-06 ko04921 Oxytocin signaling pathway 26/367 209/7206 1.91739243589e-05 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/367 14/7206 3.55047684034e-05 ko04726 Serotonergic synapse 18/367 137/7206 0.000185998084003 ko04970 Salivary secretion 14/367 95/7206 0.000290564405244 ko04010 MAPK signaling pathway 31/367 321/7206 0.000593752467382 ko04060 Cytokine-cytokine receptor interaction 1/367 191/7206 0.00113838602244 ko05014 Amyotrophic lateral sclerosis (ALS) 11/367 74/7206 0.00119069875831 ko04972 Pancreatic secretion 14/367 111/7206 0.0014260396169 ko04720 Long-term potentiation 13/367 99/7206 0.00144191093561 ko04966 Collecting duct acid secretion 6/367 26/7206 0.0016170443393 ko05031 Amphetamine addiction 12/367 91/7206 0.0020970788005 ko04550 Signaling pathways regulating pluripotency of stem cells 1/367 165/7206 0.00338934035406 ko05164 Influenza A 1/367 167/7206 0.00349517730992 ko05030 Cocaine addiction 10/367 73/7206 0.00365297139256 ko04260 Cardiac muscle contraction 12/367 98/7206 0.00392246909671 ko04022 cGMP-PKG signaling pathway 21/367 216/7206 0.00405294713695 ko05110 Vibrio cholerae infection 9/367 63/7206 0.00430665771292 ko04730 Long-term depression 10/367 78/7206 0.00590746342933 ko03040 Spliceosome 1/367 145/7206 0.00699415196673 ko05322 Systemic lupus erythematosus 1/367 151/7206 0.00733985229589 ko05168 Herpes simplex infection 2/367 182/7206 0.00907775400963 ko04120 Ubiquitin mediated proteolysis 1/367 138/7206 0.0101541065009 ko04020 Calcium signaling pathway 23/367 265/7206 0.0143047364069 ko05410 Hypertrophic cardiomyopathy (HCM) 11/367 100/7206 0.0175942751313 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 9/367 79/7206 0.0183967415693 ko04360 Axon guidance 20/367 233/7206 0.0215612363767 ko04940 Type I diabetes mellitus 5/367 32/7206 0.0215764848191 ko05205 Proteoglycans in cancer 6/367 271/7206 0.0236444173408 ko05203 Viral carcinogenesis 6/367 277/7206 0.0242988347779 ko05120 Epithelial cell signaling in Helicobacter pylori infection 10/367 92/7206 0.0259925683024 ko04071 Sphingolipid signaling pathway 15/367 162/7206 0.0271395234928 ko00680 Methane metabolism 5/367 34/7206 0.0274534337504 ko05166 HTLV-I infection 7/367 292/7206 0.0290634888819 ko04961 Endocrine and other factor-regulated calcium reabsorption 7/367 59/7206 0.0292729545032 ko05414 Dilated cardiomyopathy 11/367 112/7206 0.0295957847757 ko04971 Gastric acid secretion 10/367 98/7206 0.032654963733 ko04742 Taste transduction 7/367 61/7206 0.0343599606638 ko05224 Breast cancer 3/367 174/7206 0.0354655239699 ko05161 Hepatitis B 3/367 173/7206 0.035465948921 ko02024 Quorum sensing 3/367 15/7206 0.0377674733024 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 3/367 15/7206 0.0377674733024 ko04924 Renin secretion 9/367 86/7206 0.0410510622068 ko04745 Phototransduction - fly 5/367 38/7206 0.0420246630305 ko01521 EGFR tyrosine kinase inhibitor resistance 1/367 106/7206 0.0441141478023 ko00240 Pyrimidine metabolism 1/367 110/7206 0.045157783841 ko04145 Phagosome 14/367 162/7206 0.0456151560999 ko05215 Prostate cancer 1/367 111/7206 0.0456817482066 ko03013 RNA transport 3/367 166/7206 0.0485682835168