ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 54/727 145/7206 9.53782676378e-19 ko03030 DNA replication 22/727 38/7206 4.18434564111e-13 ko05217 Basal cell carcinoma 29/727 68/7206 2.26934888781e-12 ko04550 Signaling pathways regulating pluripotency of stem cells 48/727 165/7206 4.20228218947e-12 ko04110 Cell cycle 42/727 145/7206 1.11916649261e-10 ko04080 Neuroactive ligand-receptor interaction 10/727 423/7206 3.7332808979e-10 ko04111 Cell cycle - yeast 29/727 90/7206 6.22768109227e-09 ko03015 mRNA surveillance pathway 29/727 93/7206 1.44270794223e-08 ko04390 Hippo signaling pathway 45/727 188/7206 2.09857145699e-08 ko04340 Hedgehog signaling pathway 20/727 58/7206 4.17577554395e-07 ko04310 Wnt signaling pathway 41/727 181/7206 4.93239876016e-07 ko04144 Endocytosis 11/727 342/7206 1.33295528442e-06 ko03410 Base excision repair 15/727 38/7206 1.662062029e-06 ko04113 Meiosis - yeast 21/727 70/7206 2.90317870605e-06 ko04072 Phospholipase D signaling pathway 3/727 197/7206 2.99109016665e-06 ko04020 Calcium signaling pathway 7/727 265/7206 3.54256196892e-06 ko04330 Notch signaling pathway 19/727 62/7206 6.0764034335e-06 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/727 182/7206 8.79967406546e-06 ko05224 Breast cancer 37/727 174/7206 9.10106251291e-06 ko05012 Parkinson's disease 2/727 155/7206 1.87989574924e-05 ko04724 Glutamatergic synapse 2/727 152/7206 2.82772154483e-05 ko05010 Alzheimer's disease 5/727 202/7206 4.29743627424e-05 ko04950 Maturity onset diabetes of the young 11/727 29/7206 6.42731632572e-05 ko04725 Cholinergic synapse 3/727 160/7206 8.47372914791e-05 ko03420 Nucleotide excision repair 14/727 46/7206 0.000110574350361 ko04060 Cytokine-cytokine receptor interaction 5/727 191/7206 0.000124632335212 ko04723 Retrograde endocannabinoid signaling 5/727 175/7206 0.00049332915485 ko04726 Serotonergic synapse 3/727 137/7206 0.000507402871997 ko04650 Natural killer cell mediated cytotoxicity 1/727 97/7206 0.000570452982033 ko03013 RNA transport 31/727 166/7206 0.000607378072499 ko05231 Choline metabolism in cancer 3/727 134/7206 0.000727654947087 ko04360 Axon guidance 40/727 233/7206 0.000794739275704 ko03430 Mismatch repair 8/727 22/7206 0.000911270110314 ko00190 Oxidative phosphorylation 3/727 127/7206 0.00150418367515 ko04621 NOD-like receptor signaling pathway 5/727 157/7206 0.00181664634513 ko04062 Chemokine signaling pathway 8/727 201/7206 0.00186016077866 ko00240 Pyrimidine metabolism 22/727 110/7206 0.00193771094794 ko05166 HTLV-I infection 46/727 292/7206 0.0019745259845 ko04391 Hippo signaling pathway - fly 19/727 90/7206 0.00208369419841 ko03050 Proteasome 13/727 54/7206 0.00222926141145 ko05202 Transcriptional misregulation in cancer 32/727 188/7206 0.0029334339253 ko04921 Oxytocin signaling pathway 9/727 209/7206 0.00328240310082 ko04610 Complement and coagulation cascades 1/727 79/7206 0.00404093236284 ko04350 TGF-beta signaling pathway 20/727 103/7206 0.00424135180591 ko04138 Autophagy - yeast 1/727 81/7206 0.00429087908396 ko04915 Estrogen signaling pathway 4/727 131/7206 0.00475628358255 ko05205 Proteoglycans in cancer 42/727 271/7206 0.00518701058157 ko05211 Renal cell carcinoma 2/727 96/7206 0.005389569745 ko04727 GABAergic synapse 3/727 110/7206 0.00600312715677 ko05032 Morphine addiction 3/727 110/7206 0.00600312715677 ko04141 Protein processing in endoplasmic reticulum 8/727 184/7206 0.00605085669135 ko03020 RNA polymerase 8/727 29/7206 0.00647419844009 ko05169 Epstein-Barr virus infection 33/727 206/7206 0.00662886970061 ko04920 Adipocytokine signaling pathway 2/727 89/7206 0.00744554534267 ko04066 HIF-1 signaling pathway 4/727 123/7206 0.00921900310306 ko04010 MAPK signaling pathway 19/727 321/7206 0.0101273212329 ko04213 Longevity regulating pathway - multiple species 2/727 86/7206 0.0106977226231 ko04217 Necroptosis 8/727 178/7206 0.0109756407601 ko04022 cGMP-PKG signaling pathway 11/727 216/7206 0.0111576415422 ko05130 Pathogenic Escherichia coli infection 15/727 77/7206 0.0116508792969 ko04630 Jak-STAT signaling pathway 5/727 132/7206 0.0122827809953 ko04911 Insulin secretion 4/727 117/7206 0.0123080486091 ko04114 Oocyte meiosis 23/727 139/7206 0.0151448886201 ko04971 Gastric acid secretion 3/727 98/7206 0.0166647473052 ko01200 Carbon metabolism 5/727 128/7206 0.016730481681 ko04922 Glucagon signaling pathway 5/727 128/7206 0.016730481681 ko05146 Amoebiasis 3/727 99/7206 0.0169717384448 ko04212 Longevity regulating pathway - worm 16/727 87/7206 0.0178064498223 ko04913 Ovarian steroidogenesis 1/727 63/7206 0.0187443424048 ko00600 Sphingolipid metabolism 1/727 63/7206 0.0187443424048 ko04713 Circadian entrainment 6/727 136/7206 0.0213158369677 ko04931 Insulin resistance 6/727 137/7206 0.0213226118473 ko04371 Apelin signaling pathway 9/727 177/7206 0.0224161207478 ko04976 Bile secretion 2/727 80/7206 0.0226051777764 ko04916 Melanogenesis 23/727 142/7206 0.0229779539028 ko04024 cAMP signaling pathway 17/727 279/7206 0.0250431449992 ko04712 Circadian rhythm - plant 3/727 7/7206 0.0262399686952 ko04013 MAPK signaling pathway - fly 19/727 115/7206 0.0278885988157 ko05206 MicroRNAs in cancer 27/727 177/7206 0.0304627986521 ko05030 Cocaine addiction 2/727 73/7206 0.0307120864937 ko04662 B cell receptor signaling pathway 3/727 88/7206 0.031802172749 ko04925 Aldosterone synthesis and secretion 4/727 105/7206 0.0319540911002 ko04146 Peroxisome 3/727 89/7206 0.0319861201131 ko04612 Antigen processing and presentation 14/727 77/7206 0.0331036887667 ko03008 Ribosome biogenesis in eukaryotes 14/727 79/7206 0.0358439155175 ko03010 Ribosome 6/727 129/7206 0.0378510464446 ko00280 Valine, leucine and isoleucine degradation 1/727 54/7206 0.039502526805 ko05416 Viral myocarditis 1/727 55/7206 0.0399692465267 ko05033 Nicotine addiction 1/727 56/7206 0.0408414193486 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 6/727 26/7206 0.0410731857273 ko04620 Toll-like receptor signaling pathway 4/727 100/7206 0.0430408649702 ko04218 Cellular senescence 26/727 177/7206 0.0434531384726 ko04140 Autophagy - animal 9/727 164/7206 0.0484488186439 ko04211 Longevity regulating pathway 6/727 123/7206 0.0498784572647