ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 55/722 145/7206 1.19211924881e-19 ko03030 DNA replication 22/722 38/7206 3.62915282752e-13 ko05217 Basal cell carcinoma 29/722 68/7206 1.90462201346e-12 ko04550 Signaling pathways regulating pluripotency of stem cells 45/722 165/7206 1.73189898395e-10 ko04080 Neuroactive ligand-receptor interaction 12/722 423/7206 8.78817036428e-09 ko04110 Cell cycle 38/722 145/7206 1.56448266424e-08 ko04111 Cell cycle - yeast 28/722 90/7206 2.33310024342e-08 ko03015 mRNA surveillance pathway 28/722 93/7206 5.16781862265e-08 ko04144 Endocytosis 9/722 342/7206 1.47115287754e-07 ko04390 Hippo signaling pathway 43/722 188/7206 1.75017029864e-07 ko04020 Calcium signaling pathway 5/722 265/7206 1.88446480269e-07 ko03410 Base excision repair 15/722 38/7206 1.52179656115e-06 ko04340 Hedgehog signaling pathway 19/722 58/7206 1.78808658766e-06 ko05010 Alzheimer's disease 3/722 202/7206 2.02920744734e-06 ko05224 Breast cancer 38/722 174/7206 2.61082880055e-06 ko04310 Wnt signaling pathway 39/722 181/7206 3.46881925871e-06 ko04330 Notch signaling pathway 19/722 62/7206 5.488247224e-06 ko03050 Proteasome 17/722 54/7206 1.14432821132e-05 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/722 182/7206 1.35393975662e-05 ko04072 Phospholipase D signaling pathway 4/722 197/7206 1.75449320151e-05 ko05012 Parkinson's disease 2/722 155/7206 1.8724450471e-05 ko04724 Glutamatergic synapse 2/722 152/7206 2.77676800631e-05 ko04113 Meiosis - yeast 19/722 70/7206 3.75639381846e-05 ko04950 Maturity onset diabetes of the young 11/722 29/7206 6.02885548909e-05 ko04921 Oxytocin signaling pathway 6/722 209/7206 9.77594426546e-05 ko04723 Retrograde endocannabinoid signaling 4/722 175/7206 0.000104119572997 ko03013 RNA transport 33/722 166/7206 0.000109466595433 ko03420 Nucleotide excision repair 13/722 46/7206 0.000408333408126 ko04725 Cholinergic synapse 4/722 160/7206 0.000433473897524 ko04971 Gastric acid secretion 1/722 98/7206 0.000571619173773 ko04350 TGF-beta signaling pathway 22/722 103/7206 0.000666591415428 ko04022 cGMP-PKG signaling pathway 8/722 216/7206 0.000751355621793 ko04726 Serotonergic synapse 3/722 137/7206 0.00075825074406 ko03430 Mismatch repair 8/722 22/7206 0.000870155145116 ko04650 Natural killer cell mediated cytotoxicity 1/722 97/7206 0.00089034952747 ko04915 Estrogen signaling pathway 3/722 131/7206 0.00104471140164 ko04727 GABAergic synapse 2/722 110/7206 0.00120351267756 ko05032 Morphine addiction 2/722 110/7206 0.00120351267756 ko05202 Transcriptional misregulation in cancer 33/722 188/7206 0.0012209053798 ko04060 Cytokine-cytokine receptor interaction 7/722 191/7206 0.00138386356592 ko00190 Oxidative phosphorylation 3/722 127/7206 0.0014903412479 ko00240 Pyrimidine metabolism 22/722 110/7206 0.00188072861933 ko05169 Epstein-Barr virus infection 35/722 206/7206 0.0019637913983 ko04391 Hippo signaling pathway - fly 19/722 90/7206 0.00202502340439 ko04360 Axon guidance 38/722 233/7206 0.00251047773809 ko04141 Protein processing in endoplasmic reticulum 7/722 184/7206 0.00258198953113 ko04062 Chemokine signaling pathway 8/722 201/7206 0.00260436642128 ko04925 Aldosterone synthesis and secretion 2/722 105/7206 0.0026252742506 ko04024 cAMP signaling pathway 14/722 279/7206 0.0030293132548 ko05231 Choline metabolism in cancer 4/722 134/7206 0.00330772316328 ko04713 Circadian entrainment 4/722 136/7206 0.00341729494143 ko04610 Complement and coagulation cascades 1/722 79/7206 0.00402260095096 ko04138 Autophagy - yeast 1/722 81/7206 0.00421275405508 ko04371 Apelin signaling pathway 7/722 177/7206 0.00482357137531 ko04970 Salivary secretion 2/722 95/7206 0.00523498221735 ko04070 Phosphatidylinositol signaling system 3/722 112/7206 0.00615147505583 ko03020 RNA polymerase 8/722 29/7206 0.00620993027259 ko04621 NOD-like receptor signaling pathway 6/722 157/7206 0.00660232677328 ko04922 Glucagon signaling pathway 4/722 128/7206 0.00666953630436 ko03008 Ribosome biogenesis in eukaryotes 16/722 79/7206 0.00678360665179 ko04211 Longevity regulating pathway 4/722 123/7206 0.00907209495148 ko04066 HIF-1 signaling pathway 4/722 123/7206 0.00907209495148 ko04213 Longevity regulating pathway - multiple species 2/722 86/7206 0.0106858762273 ko04630 Jak-STAT signaling pathway 5/722 132/7206 0.0122170101773 ko05200 Pathways in cancer 66/722 492/7206 0.0125616159252 ko05205 Proteoglycans in cancer 40/722 271/7206 0.0127924515344 ko04910 Insulin signaling pathway 8/722 172/7206 0.0141661471029 ko05166 HTLV-I infection 42/722 292/7206 0.0164033961977 ko04720 Long-term potentiation 3/722 99/7206 0.0167859560436 ko05146 Amoebiasis 3/722 99/7206 0.0167859560436 ko04913 Ovarian steroidogenesis 1/722 63/7206 0.0186689374526 ko00600 Sphingolipid metabolism 1/722 63/7206 0.0186689374526 ko04270 Vascular smooth muscle contraction 7/722 154/7206 0.0201954883339 ko04931 Insulin resistance 6/722 137/7206 0.0213541918198 ko04740 Olfactory transduction 2/722 80/7206 0.0223463600608 ko04912 GnRH signaling pathway 5/722 122/7206 0.022415821431 ko04666 Fc gamma R-mediated phagocytosis 5/722 122/7206 0.022415821431 ko05211 Renal cell carcinoma 3/722 96/7206 0.0239476314676 ko04611 Platelet activation 8/722 163/7206 0.0244699278941 ko04712 Circadian rhythm - plant 3/722 7/7206 0.0257584550121 ko01212 Fatty acid metabolism 1/722 60/7206 0.0277745472115 ko05030 Cocaine addiction 2/722 73/7206 0.030758481789 ko04662 B cell receptor signaling pathway 3/722 88/7206 0.0318546250462 ko04920 Adipocytokine signaling pathway 3/722 89/7206 0.0319059077534 ko05130 Pathogenic Escherichia coli infection 14/722 77/7206 0.0326119539865 ko03010 Ribosome 6/722 129/7206 0.037796936518 ko00280 Valine, leucine and isoleucine degradation 1/722 54/7206 0.039502636709 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 6/722 26/7206 0.0398938910004 ko04911 Insulin secretion 5/722 117/7206 0.0415004640187 ko04620 Toll-like receptor signaling pathway 4/722 100/7206 0.0428836209398 ko04140 Autophagy - animal 9/722 164/7206 0.0484559322263 ko04341 Hedgehog signaling pathway - fly 8/722 38/7206 0.0496499422922