ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 70/765 152/7206 1.98936888411e-29 ko05033 Nicotine addiction 41/765 56/7206 1.49367337193e-28 ko04080 Neuroactive ligand-receptor interaction 120/765 423/7206 5.57594036144e-26 ko05032 Morphine addiction 55/765 110/7206 1.54847529647e-25 ko04727 GABAergic synapse 50/765 110/7206 5.822149521e-21 ko04723 Retrograde endocannabinoid signaling 64/765 175/7206 2.38175062363e-20 ko04713 Circadian entrainment 54/765 136/7206 3.21380102865e-19 ko04728 Dopaminergic synapse 63/765 185/7206 3.22901631225e-18 ko04725 Cholinergic synapse 56/765 160/7206 6.38690761217e-17 ko04024 cAMP signaling pathway 76/765 279/7206 1.63333498853e-15 ko04020 Calcium signaling pathway 68/765 265/7206 1.3345762597e-12 ko04921 Oxytocin signaling pathway 58/765 209/7206 1.89444602216e-12 ko04261 Adrenergic signaling in cardiomyocytes 55/765 205/7206 3.12040901544e-11 ko04010 MAPK signaling pathway 74/765 321/7206 4.66672762658e-11 ko04911 Insulin secretion 36/765 117/7206 1.59939681672e-09 ko04726 Serotonergic synapse 39/765 137/7206 4.05436351493e-09 ko05031 Amphetamine addiction 30/765 91/7206 6.1859776492e-09 ko05030 Cocaine addiction 26/765 73/7206 1.0271900501e-08 ko04720 Long-term potentiation 31/765 99/7206 1.39003354982e-08 ko04721 Synaptic vesicle cycle 27/765 80/7206 2.02512715985e-08 ko04742 Taste transduction 23/765 61/7206 2.10988282193e-08 ko04925 Aldosterone synthesis and secretion 31/765 105/7206 6.45751698128e-08 ko04744 Phototransduction 15/765 36/7206 1.40078923745e-06 ko03040 Spliceosome 1/765 145/7206 2.03786683829e-06 ko05414 Dilated cardiomyopathy 29/765 112/7206 3.44124934345e-06 ko05203 Viral carcinogenesis 9/765 277/7206 5.91189339642e-06 ko04360 Axon guidance 47/765 233/7206 1.12339350428e-05 ko04970 Salivary secretion 25/765 95/7206 1.19019883735e-05 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 22/765 79/7206 1.49996900489e-05 ko04930 Type II diabetes mellitus 17/765 54/7206 2.46206376286e-05 ko04514 Cell adhesion molecules (CAMs) 30/765 130/7206 3.43908891249e-05 ko04730 Long-term depression 21/765 78/7206 4.07354256375e-05 ko04072 Phospholipase D signaling pathway 40/765 197/7206 4.93400862647e-05 ko04022 cGMP-PKG signaling pathway 42/765 216/7206 0.000108555795786 ko04060 Cytokine-cytokine receptor interaction 6/765 191/7206 0.000185209152794 ko04260 Cardiac muscle contraction 23/765 98/7206 0.000194787018785 ko00604 Glycosphingolipid biosynthesis - ganglio series 7/765 14/7206 0.000259545345721 ko04740 Olfactory transduction 20/765 80/7206 0.000308513704712 ko05322 Systemic lupus erythematosus 4/765 151/7206 0.000417992128942 ko03013 RNA transport 5/765 166/7206 0.000474751803003 ko04923 Regulation of lipolysis in adipocytes 19/765 77/7206 0.000493692108788 ko04915 Estrogen signaling pathway 27/765 131/7206 0.000781747924116 ko05410 Hypertrophic cardiomyopathy (HCM) 22/765 100/7206 0.00080457321438 ko04014 Ras signaling pathway 47/765 279/7206 0.00138479317141 ko05014 Amyotrophic lateral sclerosis (ALS) 17/765 74/7206 0.00179906303802 ko03018 RNA degradation 1/765 84/7206 0.0018796855924 ko04110 Cell cycle 5/765 145/7206 0.00245013630161 ko04912 GnRH signaling pathway 24/765 122/7206 0.00261358901113 ko04750 Inflammatory mediator regulation of TRP channels 24/765 122/7206 0.00261358901113 ko03008 Ribosome biogenesis in eukaryotes 1/765 79/7206 0.00268001322058 ko04144 Endocytosis 54/765 342/7206 0.00283342054294 ko00515 Mannose type O-glycan biosynthesis 8/765 25/7206 0.00324134589192 ko04971 Gastric acid secretion 20/765 98/7206 0.0041666214782 ko04612 Antigen processing and presentation 1/765 77/7206 0.00419017070486 ko00240 Pyrimidine metabolism 3/765 110/7206 0.00429211060992 ko04972 Pancreatic secretion 22/765 111/7206 0.0044342080879 ko04070 Phosphatidylinositol signaling system 22/765 112/7206 0.00462100369704 ko04670 Leukocyte transendothelial migration 6/765 151/7206 0.00468453434461 ko04145 Phagosome 7/765 162/7206 0.00625447240264 ko04012 ErbB signaling pathway 21/765 109/7206 0.00679922926026 ko04141 Protein processing in endoplasmic reticulum 9/765 184/7206 0.00743975511246 ko04722 Neurotrophin signaling pathway 28/765 160/7206 0.00870858552082 ko05231 Choline metabolism in cancer 24/765 134/7206 0.00999513821824 ko04640 Hematopoietic cell lineage 1/765 64/7206 0.0126430925264 ko00562 Inositol phosphate metabolism 17/765 89/7206 0.01430852646 ko05130 Pathogenic Escherichia coli infection 2/765 77/7206 0.0149425300113 ko04914 Progesterone-mediated oocyte maturation 19/765 104/7206 0.0155874745776 ko05162 Measles 5/765 120/7206 0.0162595439284 ko00330 Arginine and proline metabolism 1/765 61/7206 0.0189414292333 ko04115 p53 signaling pathway 2/765 74/7206 0.0213975768472 ko05210 Colorectal cancer 16/765 86/7206 0.0214615292525 ko05164 Influenza A 9/765 167/7206 0.0221015844281 ko00520 Amino sugar and nucleotide sugar metabolism 1/765 55/7206 0.0266557869253 ko05416 Viral myocarditis 1/765 55/7206 0.0266557869253 ko01522 Endocrine resistance 21/765 124/7206 0.0269067163946 ko05321 Inflammatory bowel disease (IBD) 1/765 56/7206 0.0269469872907 ko00190 Oxidative phosphorylation 6/765 127/7206 0.0281790149111 ko00512 Mucin type O-glycan biosynthesis 7/765 29/7206 0.0287199063746 ko04371 Apelin signaling pathway 28/765 177/7206 0.0344544183234 ko00510 N-Glycan biosynthesis 10/765 50/7206 0.0383321181067 ko05169 Epstein-Barr virus infection 13/765 206/7206 0.038929962273 ko04540 Gap junction 21/765 128/7206 0.0412658689084 ko04064 NF-kappa B signaling pathway 4/765 96/7206 0.0430414611661 ko04621 NOD-like receptor signaling pathway 9/765 157/7206 0.0482055204577 ko04062 Chemokine signaling pathway 30/765 201/7206 0.0483831279317 ko05168 Herpes simplex infection 11/765 182/7206 0.0498178967261