ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	192/1176	423/7206	3.85807400893e-48
ko04724	Glutamatergic synapse	85/1176	152/7206	1.79605988005e-29
ko05033	Nicotine addiction	46/1176	56/7206	1.91750117264e-27
ko05032	Morphine addiction	64/1176	110/7206	1.00514176008e-23
ko04713	Circadian entrainment	71/1176	136/7206	2.1840271775e-22
ko04727	GABAergic synapse	61/1176	110/7206	3.58582392419e-21
ko04721	Synaptic vesicle cycle	50/1176	80/7206	1.03200121499e-20
ko04728	Dopaminergic synapse	81/1176	185/7206	3.61926626885e-19
ko04725	Cholinergic synapse	72/1176	160/7206	5.82306906306e-18
ko04024	cAMP signaling pathway	101/1176	279/7206	1.94277229656e-16
ko04020	Calcium signaling pathway	95/1176	265/7206	3.11290812611e-15
ko04723	Retrograde endocannabinoid signaling	71/1176	175/7206	7.93005239828e-15
ko04921	Oxytocin signaling pathway	76/1176	209/7206	1.29569463961e-12
ko04726	Serotonergic synapse	56/1176	137/7206	4.12728921314e-12
ko04742	Taste transduction	33/1176	61/7206	1.24543594495e-11
ko04911	Insulin secretion	49/1176	117/7206	3.27304036812e-11
ko05031	Amphetamine addiction	41/1176	91/7206	8.68023426889e-11
ko04744	Phototransduction	23/1176	36/7206	1.72019318898e-10
ko04720	Long-term potentiation	41/1176	99/7206	2.02176135035e-09
ko03010	Ribosome	1/1176	129/7206	4.11152380577e-09
ko04970	Salivary secretion	38/1176	95/7206	2.46655953821e-08
ko03040	Spliceosome	3/1176	145/7206	3.86236578019e-08
ko04261	Adrenergic signaling in cardiomyocytes	65/1176	205/7206	4.14695601686e-08
ko04966	Collecting duct acid secretion	16/1176	26/7206	2.38755811341e-07
ko04022	cGMP-PKG signaling pathway	65/1176	216/7206	2.90451622501e-07
ko04740	Olfactory transduction	32/1176	80/7206	3.13862154309e-07
ko05322	Systemic lupus erythematosus	5/1176	151/7206	5.81948467787e-07
ko04925	Aldosterone synthesis and secretion	38/1176	105/7206	6.77469597959e-07
ko05168	Herpes simplex infection	8/1176	182/7206	7.30965597918e-07
ko05203	Viral carcinogenesis	18/1176	277/7206	1.13779679033e-06
ko05030	Cocaine addiction	29/1176	73/7206	1.32621296209e-06
ko03013	RNA transport	7/1176	166/7206	1.90171697425e-06
ko04971	Gastric acid secretion	34/1176	98/7206	6.71761009291e-06
ko04730	Long-term depression	29/1176	78/7206	7.23064601931e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1176	74/7206	7.95119330756e-06
ko04360	Axon guidance	64/1176	233/7206	1.23207709998e-05
ko04060	Cytokine-cytokine receptor interaction	11/1176	191/7206	1.5134798113e-05
ko04120	Ubiquitin mediated proteolysis	6/1176	138/7206	2.05417188929e-05
ko04141	Protein processing in endoplasmic reticulum	11/1176	184/7206	2.82350249383e-05
ko04110	Cell cycle	7/1176	145/7206	3.30323596812e-05
ko04371	Apelin signaling pathway	50/1176	177/7206	4.91804475184e-05
ko04070	Phosphatidylinositol signaling system	35/1176	112/7206	8.02202480283e-05
ko04514	Cell adhesion molecules (CAMs)	39/1176	130/7206	9.62491569009e-05
ko04010	MAPK signaling pathway	79/1176	321/7206	0.000101085536386
ko04745	Phototransduction - fly	16/1176	38/7206	0.000141276195394
ko03008	Ribosome biogenesis in eukaryotes	2/1176	79/7206	0.000171614078537
ko04924	Renin secretion	28/1176	86/7206	0.000177222360046
ko04014	Ras signaling pathway	69/1176	279/7206	0.000252485105427
ko05164	Influenza A	11/1176	167/7206	0.000269297415043
ko04922	Glucagon signaling pathway	36/1176	128/7206	0.000642159812463
ko04540	Gap junction	36/1176	128/7206	0.000642159812463
ko05169	Epstein-Barr virus infection	17/1176	206/7206	0.000780309707758
ko05110	Vibrio cholerae infection	21/1176	63/7206	0.000841321533851
ko04972	Pancreatic secretion	32/1176	111/7206	0.00102107806695
ko04976	Bile secretion	25/1176	80/7206	0.00110630930926
ko04915	Estrogen signaling pathway	36/1176	131/7206	0.00112680115202
ko04072	Phospholipase D signaling pathway	50/1176	197/7206	0.00114825726139
ko04964	Proximal tubule bicarbonate reclamation	12/1176	29/7206	0.00115809851441
ko04750	Inflammatory mediator regulation of TRP channels	34/1176	122/7206	0.00115836306436
ko04710	Circadian rhythm	16/1176	43/7206	0.00120904887395
ko00520	Amino sugar and nucleotide sugar metabolism	1/1176	55/7206	0.00135826834622
ko05140	Leishmaniasis	3/1176	75/7206	0.00149996279165
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/1176	79/7206	0.00181486743658
ko05205	Proteoglycans in cancer	26/1176	271/7206	0.00183242057148
ko05166	HTLV-I infection	29/1176	292/7206	0.00203322165226
ko04621	NOD-like receptor signaling pathway	12/1176	157/7206	0.00204824291283
ko04330	Notch signaling pathway	2/1176	62/7206	0.0027294760546
ko04923	Regulation of lipolysis in adipocytes	23/1176	77/7206	0.00276672897509
ko04610	Complement and coagulation cascades	4/1176	79/7206	0.0034286799872
ko03420	Nucleotide excision repair	1/1176	46/7206	0.00442007780271
ko04626	Plant-pathogen interaction	8/1176	18/7206	0.00462029677625
ko05161	Hepatitis B	15/1176	173/7206	0.00467995754578
ko04612	Antigen processing and presentation	4/1176	77/7206	0.00484852605177
ko04260	Cardiac muscle contraction	27/1176	98/7206	0.00531118882145
ko00480	Glutathione metabolism	2/1176	55/7206	0.00570656427698
ko05162	Measles	9/1176	120/7206	0.00590875474185
ko04350	TGF-beta signaling pathway	7/1176	103/7206	0.00668576881541
ko03022	Basal transcription factors	1/1176	44/7206	0.00668713264866
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1176	59/7206	0.00679263911104
ko00280	Valine, leucine and isoleucine degradation	2/1176	54/7206	0.0084629159691
ko00240	Pyrimidine metabolism	8/1176	110/7206	0.00866170325663
ko04622	RIG-I-like receptor signaling pathway	3/1176	62/7206	0.00924231833383
ko05414	Dilated cardiomyopathy	29/1176	112/7206	0.00934735381189
ko04214	Apoptosis - fly	4/1176	72/7206	0.00964413916341
ko04064	NF-kappa B signaling pathway	7/1176	96/7206	0.01215275249
ko04657	IL-17 signaling pathway	6/1176	87/7206	0.0128209491384
ko05133	Pertussis	6/1176	87/7206	0.0128209491384
ko04146	Peroxisome	6/1176	89/7206	0.0131414873816
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1176	14/7206	0.0171735006331
ko03018	RNA degradation	6/1176	84/7206	0.0174767855919
ko05219	Bladder cancer	2/1176	48/7206	0.0176041792085
ko05217	Basal cell carcinoma	4/1176	68/7206	0.0193909610346
ko05230	Central carbon metabolism in cancer	21/1176	81/7206	0.0232199971006
ko05206	MicroRNAs in cancer	18/1176	177/7206	0.0232628990329
ko04217	Necroptosis	18/1176	178/7206	0.023356040118
ko05131	Shigellosis	6/1176	82/7206	0.0236398640827
ko04115	p53 signaling pathway	5/1176	74/7206	0.0254404672107
ko00071	Fatty acid degradation	2/1176	45/7206	0.0254475120384
ko05321	Inflammatory bowel disease (IBD)	3/1176	56/7206	0.0272099148544
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1176	100/7206	0.0279356399041
ko04510	Focal adhesion	27/1176	240/7206	0.0325430414857
ko00860	Porphyrin and chlorophyll metabolism	1/1176	34/7206	0.0335040585794
ko04658	Th1 and Th2 cell differentiation	8/1176	96/7206	0.035774403025
ko00330	Arginine and proline metabolism	4/1176	61/7206	0.0361908270734
ko00590	Arachidonic acid metabolism	3/1176	52/7206	0.0372984808809
ko05016	Huntington's disease	24/1176	215/7206	0.0389116912498
ko04930	Type II diabetes mellitus	15/1176	54/7206	0.0391952906645
ko00562	Inositol phosphate metabolism	22/1176	89/7206	0.0418151679696
ko04630	Jak-STAT signaling pathway	13/1176	132/7206	0.0428719032104
ko04711	Circadian rhythm - fly	5/1176	13/7206	0.0470925294226