ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	194/1161	423/7206	1.83001637497e-50
ko04724	Glutamatergic synapse	88/1161	152/7206	1.70861001353e-32
ko05033	Nicotine addiction	47/1161	56/7206	4.20773196839e-29
ko04727	GABAergic synapse	65/1161	110/7206	6.2191422263e-25
ko05032	Morphine addiction	65/1161	110/7206	6.2191422263e-25
ko04713	Circadian entrainment	72/1161	136/7206	1.63649816847e-23
ko04721	Synaptic vesicle cycle	52/1161	80/7206	6.35944671971e-23
ko04728	Dopaminergic synapse	84/1161	185/7206	1.7859215273e-21
ko04725	Cholinergic synapse	76/1161	160/7206	5.46117543123e-21
ko04723	Retrograde endocannabinoid signaling	76/1161	175/7206	3.92935750886e-18
ko04024	cAMP signaling pathway	100/1161	279/7206	2.71232153537e-16
ko04020	Calcium signaling pathway	95/1161	265/7206	1.95447434323e-15
ko04742	Taste transduction	37/1161	61/7206	3.16188511117e-15
ko04744	Phototransduction	27/1161	36/7206	6.45304313185e-15
ko04726	Serotonergic synapse	60/1161	137/7206	9.23645162616e-15
ko04911	Insulin secretion	52/1161	117/7206	2.85837779412e-13
ko04921	Oxytocin signaling pathway	76/1161	209/7206	4.64361956118e-13
ko05031	Amphetamine addiction	41/1161	91/7206	5.73051021594e-11
ko04720	Long-term potentiation	43/1161	99/7206	8.47469714704e-11
ko03040	Spliceosome	1/1161	145/7206	3.14791026702e-10
ko04261	Adrenergic signaling in cardiomyocytes	69/1161	205/7206	4.15940563538e-10
ko04970	Salivary secretion	39/1161	95/7206	4.64734566652e-09
ko04621	NOD-like receptor signaling pathway	5/1161	157/7206	4.24639586316e-07
ko05203	Viral carcinogenesis	17/1161	277/7206	4.41736051094e-07
ko04360	Axon guidance	67/1161	233/7206	7.26304735166e-07
ko04120	Ubiquitin mediated proteolysis	4/1161	138/7206	9.59957002176e-07
ko05030	Cocaine addiction	29/1161	73/7206	1.00952846453e-06
ko05168	Herpes simplex infection	8/1161	182/7206	1.07597880741e-06
ko04925	Aldosterone synthesis and secretion	37/1161	105/7206	1.3428980772e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1161	74/7206	1.40843378479e-06
ko04966	Collecting duct acid secretion	15/1161	26/7206	1.55377712007e-06
ko04971	Gastric acid secretion	35/1161	98/7206	2.16579827081e-06
ko03013	RNA transport	7/1161	166/7206	2.85707782048e-06
ko04070	Phosphatidylinositol signaling system	38/1161	112/7206	3.05631794395e-06
ko04740	Olfactory transduction	30/1161	80/7206	3.47508905358e-06
ko05322	Systemic lupus erythematosus	6/1161	151/7206	5.01709767571e-06
ko04514	Cell adhesion molecules (CAMs)	41/1161	130/7206	9.8578336003e-06
ko04141	Protein processing in endoplasmic reticulum	10/1161	184/7206	1.49772872576e-05
ko04010	MAPK signaling pathway	81/1161	321/7206	1.70418596726e-05
ko04060	Cytokine-cytokine receptor interaction	11/1161	191/7206	2.16433094773e-05
ko05164	Influenza A	9/1161	167/7206	2.72222641209e-05
ko04972	Pancreatic secretion	35/1161	111/7206	4.18793811194e-05
ko04014	Ras signaling pathway	71/1161	279/7206	4.22197015582e-05
ko04022	cGMP-PKG signaling pathway	58/1161	216/7206	4.49797759836e-05
ko04072	Phospholipase D signaling pathway	54/1161	197/7206	4.60837281412e-05
ko04110	Cell cycle	7/1161	145/7206	4.89821080897e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1161	79/7206	7.35203041922e-05
ko04064	NF-kappa B signaling pathway	3/1161	96/7206	0.000112794540654
ko04745	Phototransduction - fly	16/1161	38/7206	0.000120784720502
ko04540	Gap junction	38/1161	128/7206	0.000130347473771
ko04730	Long-term depression	26/1161	78/7206	0.000146561482821
ko04924	Renin secretion	28/1161	86/7206	0.000154307802377
ko03008	Ribosome biogenesis in eukaryotes	2/1161	79/7206	0.000174192460565
ko05110	Vibrio cholerae infection	22/1161	63/7206	0.000212297171545
ko04612	Antigen processing and presentation	2/1161	77/7206	0.000257954935038
ko05414	Dilated cardiomyopathy	33/1161	112/7206	0.000375021216271
ko05140	Leishmaniasis	2/1161	75/7206	0.000385792836591
ko04750	Inflammatory mediator regulation of TRP channels	35/1161	122/7206	0.000419786798415
ko00562	Inositol phosphate metabolism	27/1161	89/7206	0.000695788082393
ko04260	Cardiac muscle contraction	29/1161	98/7206	0.000741773049556
ko04923	Regulation of lipolysis in adipocytes	24/1161	77/7206	0.00086939829658
ko05169	Epstein-Barr virus infection	17/1161	206/7206	0.00103511236849
ko04610	Complement and coagulation cascades	3/1161	79/7206	0.00104783544111
ko04915	Estrogen signaling pathway	35/1161	131/7206	0.00167878696342
ko04976	Bile secretion	24/1161	80/7206	0.00183564867946
ko05161	Hepatitis B	14/1161	173/7206	0.00231056620162
ko05205	Proteoglycans in cancer	26/1161	271/7206	0.00231893006877
ko04330	Notch signaling pathway	2/1161	62/7206	0.00269331316209
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1161	14/7206	0.00333674944387
ko04964	Proximal tubule bicarbonate reclamation	11/1161	29/7206	0.00376567000386
ko04626	Plant-pathogen interaction	8/1161	18/7206	0.00425698862875
ko05166	HTLV-I infection	30/1161	292/7206	0.00438266003103
ko03420	Nucleotide excision repair	1/1161	46/7206	0.00448154364375
ko04146	Peroxisome	5/1161	89/7206	0.00520363878647
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1161	59/7206	0.00643202980816
ko03022	Basal transcription factors	1/1161	44/7206	0.0066992139952
ko05144	Malaria	1/1161	45/7206	0.00684600444119
ko00071	Fatty acid degradation	1/1161	45/7206	0.00684600444119
ko05162	Measles	9/1161	120/7206	0.00804792951794
ko00480	Glutathione metabolism	2/1161	55/7206	0.00863543370732
ko04214	Apoptosis - fly	4/1161	72/7206	0.00971987294318
ko05145	Toxoplasmosis	10/1161	126/7206	0.00981674921803
ko00590	Arachidonic acid metabolism	2/1161	52/7206	0.0123974170642
ko04371	Apelin signaling pathway	41/1161	177/7206	0.0127377631394
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1161	100/7206	0.0127440373957
ko04217	Necroptosis	17/1161	178/7206	0.0131802762517
ko04622	RIG-I-like receptor signaling pathway	3/1161	62/7206	0.0136662648981
ko04930	Type II diabetes mellitus	16/1161	54/7206	0.0137789185409
ko04973	Carbohydrate digestion and absorption	13/1161	42/7206	0.0177073030467
ko05219	Bladder cancer	2/1161	48/7206	0.0177323602575
ko04657	IL-17 signaling pathway	6/1161	87/7206	0.0178223727982
ko05133	Pertussis	6/1161	87/7206	0.0178223727982
ko00240	Pyrimidine metabolism	9/1161	110/7206	0.0186689327973
ko04710	Circadian rhythm	13/1161	43/7206	0.0196684796824
ko04630	Jak-STAT signaling pathway	12/1161	132/7206	0.0232742825644
ko00630	Glyoxylate and dicarboxylate metabolism	1/1161	38/7206	0.0236108429126
ko03018	RNA degradation	6/1161	84/7206	0.0240065078268
ko04015	Rap1 signaling pathway	59/1161	278/7206	0.0242680714862
ko04510	Focal adhesion	26/1161	240/7206	0.0251261971113
ko04115	p53 signaling pathway	5/1161	74/7206	0.0252981112952
ko05321	Inflammatory bowel disease (IBD)	3/1161	56/7206	0.0268831369143
ko05206	MicroRNAs in cancer	18/1161	177/7206	0.0292975849717
ko04722	Neurotrophin signaling pathway	36/1161	160/7206	0.0296841809026
ko05016	Huntington's disease	23/1161	215/7206	0.0298033038189
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1161	92/7206	0.0307814943574
ko04062	Chemokine signaling pathway	44/1161	201/7206	0.0316531394343
ko05131	Shigellosis	6/1161	82/7206	0.0328078497897
ko00860	Porphyrin and chlorophyll metabolism	1/1161	34/7206	0.0334162288508
ko00500	Starch and sucrose metabolism	1/1161	35/7206	0.0343875326232
ko00310	Lysine degradation	5/1161	73/7206	0.0355493401395
ko04658	Th1 and Th2 cell differentiation	8/1161	96/7206	0.0356022977972
ko00280	Valine, leucine and isoleucine degradation	3/1161	54/7206	0.0384513507262
ko04210	Apoptosis	19/1161	180/7206	0.0398089112635
ko04350	TGF-beta signaling pathway	9/1161	103/7206	0.0420186824126
ko05202	Transcriptional misregulation in cancer	20/1161	188/7206	0.0436453067985
ko04912	GnRH signaling pathway	28/1161	122/7206	0.0461090805205
ko05217	Basal cell carcinoma	5/1161	68/7206	0.0467433572544
ko04114	Oocyte meiosis	31/1161	139/7206	0.0480525696096