ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	173/1079	423/7206	4.11270025966e-41
ko04724	Glutamatergic synapse	85/1079	152/7206	2.57788656342e-32
ko05032	Morphine addiction	67/1079	110/7206	1.03226009455e-28
ko04727	GABAergic synapse	63/1079	110/7206	5.84533487443e-25
ko04713	Circadian entrainment	71/1079	136/7206	1.10381907692e-24
ko05033	Nicotine addiction	42/1079	56/7206	7.96755807164e-24
ko04728	Dopaminergic synapse	84/1079	185/7206	1.15094813211e-23
ko04723	Retrograde endocannabinoid signaling	74/1079	175/7206	9.51126394374e-19
ko04024	cAMP signaling pathway	100/1079	279/7206	1.44334214703e-18
ko04721	Synaptic vesicle cycle	45/1079	80/7206	9.79916257534e-18
ko04725	Cholinergic synapse	67/1079	160/7206	8.21484066477e-17
ko04911	Insulin secretion	53/1079	117/7206	2.80828556721e-15
ko04744	Phototransduction	26/1079	36/7206	1.55069594008e-14
ko04921	Oxytocin signaling pathway	75/1079	209/7206	2.68861089476e-14
ko04020	Calcium signaling pathway	88/1079	265/7206	2.92469796765e-14
ko04726	Serotonergic synapse	56/1079	137/7206	1.04454261058e-13
ko05031	Amphetamine addiction	43/1079	91/7206	2.00113553003e-13
ko04742	Taste transduction	32/1079	61/7206	7.18889546882e-12
ko04720	Long-term potentiation	42/1079	99/7206	3.17734346007e-11
ko04261	Adrenergic signaling in cardiomyocytes	68/1079	205/7206	4.84597108971e-11
ko05030	Cocaine addiction	32/1079	73/7206	2.68972177096e-09
ko04925	Aldosterone synthesis and secretion	40/1079	105/7206	4.36861236386e-09
ko03040	Spliceosome	2/1079	145/7206	2.61768194723e-08
ko03010	Ribosome	1/1079	129/7206	2.81158571788e-08
ko04970	Salivary secretion	35/1079	95/7206	1.08529058501e-07
ko04022	cGMP-PKG signaling pathway	61/1079	216/7206	3.25876812257e-07
ko04070	Phosphatidylinositol signaling system	38/1079	112/7206	6.06793429546e-07
ko05322	Systemic lupus erythematosus	4/1079	151/7206	7.52260725015e-07
ko04971	Gastric acid secretion	34/1079	98/7206	9.62473769479e-07
ko04072	Phospholipase D signaling pathway	55/1079	197/7206	2.17548345218e-06
ko04010	MAPK signaling pathway	79/1079	321/7206	4.08889323391e-06
ko04966	Collecting duct acid secretion	14/1079	26/7206	4.32404263422e-06
ko05168	Herpes simplex infection	8/1079	182/7206	7.21847985083e-06
ko03013	RNA transport	7/1079	166/7206	1.30477303308e-05
ko05203	Viral carcinogenesis	18/1079	277/7206	1.47676222579e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1079	74/7206	1.84294367027e-05
ko04740	Olfactory transduction	27/1079	80/7206	2.23343220473e-05
ko04110	Cell cycle	6/1079	145/7206	4.80852861451e-05
ko04972	Pancreatic secretion	33/1079	111/7206	6.93629258713e-05
ko04060	Cytokine-cytokine receptor interaction	11/1079	191/7206	8.33235281735e-05
ko04360	Axon guidance	57/1079	233/7206	0.00011259067155
ko05164	Influenza A	9/1079	167/7206	0.000158532974483
ko04745	Phototransduction - fly	15/1079	38/7206	0.000200484254747
ko05110	Vibrio cholerae infection	21/1079	63/7206	0.000236563316604
ko04922	Glucagon signaling pathway	35/1079	128/7206	0.000242927411608
ko04924	Renin secretion	26/1079	86/7206	0.000333773288656
ko04730	Long-term depression	24/1079	78/7206	0.000336836997625
ko04514	Cell adhesion molecules (CAMs)	35/1079	130/7206	0.000419155915901
ko04915	Estrogen signaling pathway	35/1079	131/7206	0.000448591441887
ko04750	Inflammatory mediator regulation of TRP channels	33/1079	122/7206	0.000467744990155
ko04014	Ras signaling pathway	63/1079	279/7206	0.000576043937349
ko04612	Antigen processing and presentation	2/1079	77/7206	0.000612324787314
ko03008	Ribosome biogenesis in eukaryotes	2/1079	79/7206	0.000646754663349
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1079	59/7206	0.000720857084783
ko04371	Apelin signaling pathway	43/1079	177/7206	0.000880466883379
ko04710	Circadian rhythm	15/1079	43/7206	0.000943070862532
ko05169	Epstein-Barr virus infection	15/1079	206/7206	0.000996551788267
ko04120	Ubiquitin mediated proteolysis	8/1079	138/7206	0.00106104801956
ko05162	Measles	6/1079	120/7206	0.00107167022188
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	23/1079	79/7206	0.0012079721975
ko04260	Cardiac muscle contraction	27/1079	98/7206	0.00141348875256
ko04141	Protein processing in endoplasmic reticulum	13/1079	184/7206	0.00154702560752
ko04923	Regulation of lipolysis in adipocytes	22/1079	77/7206	0.00192767337741
ko04350	TGF-beta signaling pathway	5/1079	103/7206	0.00196179955655
ko00520	Amino sugar and nucleotide sugar metabolism	1/1079	55/7206	0.00211225153639
ko04626	Plant-pathogen interaction	8/1079	18/7206	0.00265252107759
ko05414	Dilated cardiomyopathy	29/1079	112/7206	0.00292424848229
ko04621	NOD-like receptor signaling pathway	11/1079	157/7206	0.00309237327644
ko05161	Hepatitis B	13/1079	173/7206	0.00349783977151
ko04976	Bile secretion	22/1079	80/7206	0.00388679705484
ko05140	Leishmaniasis	3/1079	75/7206	0.00493129370793
ko05205	Proteoglycans in cancer	25/1079	271/7206	0.00538941272436
ko04540	Gap junction	31/1079	128/7206	0.00553064648563
ko04930	Type II diabetes mellitus	16/1079	54/7206	0.00600443455519
ko00562	Inositol phosphate metabolism	23/1079	89/7206	0.00661422726375
ko05231	Choline metabolism in cancer	32/1079	134/7206	0.00665369659486
ko04964	Proximal tubule bicarbonate reclamation	10/1079	29/7206	0.0072114523692
ko03320	PPAR signaling pathway	3/1079	69/7206	0.00991891073557
ko04146	Peroxisome	5/1079	89/7206	0.0102617333465
ko04610	Complement and coagulation cascades	4/1079	79/7206	0.0102789512533
ko03022	Basal transcription factors	1/1079	44/7206	0.010535539131
ko04210	Apoptosis	15/1079	180/7206	0.0106734038092
ko03420	Nucleotide excision repair	1/1079	46/7206	0.0109096517447
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1079	14/7206	0.0113518576473
ko05321	Inflammatory bowel disease (IBD)	2/1079	56/7206	0.0129946777746
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1079	100/7206	0.0157093414516
ko00590	Arachidonic acid metabolism	2/1079	52/7206	0.0184512739114
ko04330	Notch signaling pathway	3/1079	62/7206	0.019604208353
ko04622	RIG-I-like receptor signaling pathway	3/1079	62/7206	0.019604208353
ko04115	p53 signaling pathway	4/1079	74/7206	0.0202660419681
ko04062	Chemokine signaling pathway	42/1079	201/7206	0.0208513374457
ko04918	Thyroid hormone synthesis	21/1079	86/7206	0.0211880731524
ko00240	Pyrimidine metabolism	8/1079	110/7206	0.0212652752328
ko05215	Prostate cancer	8/1079	111/7206	0.0215837072132
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1079	40/7206	0.0236632923075
ko04015	Rap1 signaling pathway	55/1079	278/7206	0.0256264056902
ko04510	Focal adhesion	24/1079	240/7206	0.0270167920717
ko04912	GnRH signaling pathway	27/1079	122/7206	0.0296101155632
ko04658	Th1 and Th2 cell differentiation	7/1079	96/7206	0.0305645096996
ko05016	Huntington's disease	21/1079	215/7206	0.0321718778499
ko04722	Neurotrophin signaling pathway	34/1079	160/7206	0.0324280344217
ko05133	Pertussis	6/1079	87/7206	0.0332875691039
ko04550	Signaling pathways regulating pluripotency of stem cells	15/1079	165/7206	0.0351533578255
ko04630	Jak-STAT signaling pathway	11/1079	132/7206	0.0352227517472
ko05130	Pathogenic Escherichia coli infection	5/1079	77/7206	0.0357258015366
ko05166	HTLV-I infection	31/1079	292/7206	0.0358826185461
ko00630	Glyoxylate and dicarboxylate metabolism	1/1079	38/7206	0.0361171198403
ko05217	Basal cell carcinoma	4/1079	68/7206	0.0383533411443
ko05219	Bladder cancer	2/1079	48/7206	0.0392908025505
ko05120	Epithelial cell signaling in Helicobacter pylori infection	21/1079	92/7206	0.0393036059292
ko04114	Oocyte meiosis	30/1079	139/7206	0.0401584278431
ko05034	Alcoholism	47/1079	238/7206	0.0417106048839
ko04916	Melanogenesis	30/1079	142/7206	0.0432033482186
ko03018	RNA degradation	6/1079	84/7206	0.0444859908214
ko04213	Longevity regulating pathway - multiple species	20/1079	86/7206	0.0460858621291
ko00650	Butanoate metabolism	8/1079	26/7206	0.0461381744033
ko04973	Carbohydrate digestion and absorption	11/1079	42/7206	0.0499682894999