ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	196/1169	423/7206	2.20954719989e-51
ko04724	Glutamatergic synapse	90/1169	152/7206	4.80833280028e-34
ko05033	Nicotine addiction	48/1169	56/7206	2.00785828584e-30
ko05032	Morphine addiction	68/1169	110/7206	1.61249508723e-27
ko04727	GABAergic synapse	66/1169	110/7206	1.15964678001e-25
ko04713	Circadian entrainment	74/1169	136/7206	6.23322879293e-25
ko04721	Synaptic vesicle cycle	54/1169	80/7206	7.9619351978e-25
ko04728	Dopaminergic synapse	83/1169	185/7206	1.28910987974e-20
ko04725	Cholinergic synapse	74/1169	160/7206	1.96119823471e-19
ko04723	Retrograde endocannabinoid signaling	77/1169	175/7206	1.39076339614e-18
ko04742	Taste transduction	40/1169	61/7206	5.2712121388e-18
ko04024	cAMP signaling pathway	102/1169	279/7206	3.56257955574e-17
ko04020	Calcium signaling pathway	97/1169	265/7206	2.2646703283e-16
ko04911	Insulin secretion	56/1169	117/7206	8.1700094895e-16
ko04726	Serotonergic synapse	60/1169	137/7206	1.27549907064e-14
ko04921	Oxytocin signaling pathway	79/1169	209/7206	1.95385412646e-14
ko04744	Phototransduction	26/1169	36/7206	1.10666345443e-13
ko04720	Long-term potentiation	44/1169	99/7206	2.52093600992e-11
ko05031	Amphetamine addiction	41/1169	91/7206	7.1575820156e-11
ko03040	Spliceosome	1/1169	145/7206	3.19999294633e-10
ko04970	Salivary secretion	41/1169	95/7206	3.69569791203e-10
ko04261	Adrenergic signaling in cardiomyocytes	69/1169	205/7206	4.92848720205e-10
ko05203	Viral carcinogenesis	14/1169	277/7206	9.68117104101e-09
ko04740	Olfactory transduction	34/1169	80/7206	1.90580884235e-08
ko04925	Aldosterone synthesis and secretion	41/1169	105/7206	2.05784778327e-08
ko05168	Herpes simplex infection	6/1169	182/7206	3.6120864415e-08
ko04022	cGMP-PKG signaling pathway	66/1169	216/7206	9.39312732354e-08
ko04971	Gastric acid secretion	37/1169	98/7206	2.14120681e-07
ko04966	Collecting duct acid secretion	16/1169	26/7206	2.19210175908e-07
ko05030	Cocaine addiction	30/1169	73/7206	3.19455899199e-07
ko04360	Axon guidance	68/1169	233/7206	4.59531913815e-07
ko04120	Ubiquitin mediated proteolysis	4/1169	138/7206	9.65690106894e-07
ko04060	Cytokine-cytokine receptor interaction	9/1169	191/7206	1.20833938881e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1169	74/7206	1.62806204604e-06
ko03013	RNA transport	7/1169	166/7206	1.89221264017e-06
ko05164	Influenza A	7/1169	167/7206	1.92561105877e-06
ko04260	Cardiac muscle contraction	35/1169	98/7206	2.37822992723e-06
ko04540	Gap junction	42/1169	128/7206	2.7140134468e-06
ko05322	Systemic lupus erythematosus	7/1169	151/7206	1.64510906363e-05
ko05169	Epstein-Barr virus infection	13/1169	206/7206	2.07237232781e-05
ko04924	Renin secretion	30/1169	86/7206	2.10386744738e-05
ko04972	Pancreatic secretion	36/1169	111/7206	2.13756294344e-05
ko04010	MAPK signaling pathway	81/1169	321/7206	2.50437671851e-05
ko04621	NOD-like receptor signaling pathway	8/1169	157/7206	2.5313067503e-05
ko04514	Cell adhesion molecules (CAMs)	40/1169	130/7206	3.18254133604e-05
ko04141	Protein processing in endoplasmic reticulum	11/1169	184/7206	4.04840266407e-05
ko05162	Measles	5/1169	120/7206	7.94909094677e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1169	79/7206	7.9947692548e-05
ko05110	Vibrio cholerae infection	23/1169	63/7206	8.59172167403e-05
ko04976	Bile secretion	27/1169	80/7206	9.67832583781e-05
ko04745	Phototransduction - fly	16/1169	38/7206	0.000131358626111
ko04110	Cell cycle	8/1169	145/7206	0.000140571334209
ko04730	Long-term depression	26/1169	78/7206	0.000160968443861
ko03008	Ribosome biogenesis in eukaryotes	2/1169	79/7206	0.00017205850532
ko05205	Proteoglycans in cancer	23/1169	271/7206	0.000204020619582
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1169	59/7206	0.000250927126064
ko05161	Hepatitis B	12/1169	173/7206	0.000347232100417
ko05140	Leishmaniasis	2/1169	75/7206	0.000389111534769
ko04064	NF-kappa B signaling pathway	4/1169	96/7206	0.000404422743135
ko04750	Inflammatory mediator regulation of TRP channels	35/1169	122/7206	0.000449465497444
ko04626	Plant-pathogen interaction	9/1169	18/7206	0.000909020021844
ko05414	Dilated cardiomyopathy	32/1169	112/7206	0.00104682962869
ko04610	Complement and coagulation cascades	3/1169	79/7206	0.00104758970652
ko04964	Proximal tubule bicarbonate reclamation	12/1169	29/7206	0.00109674488814
ko04014	Ras signaling pathway	66/1169	279/7206	0.00116292525739
ko04146	Peroxisome	4/1169	89/7206	0.00121504351835
ko00520	Amino sugar and nucleotide sugar metabolism	1/1169	55/7206	0.00134239773118
ko00480	Glutathione metabolism	1/1169	55/7206	0.00134239773118
ko04612	Antigen processing and presentation	3/1169	77/7206	0.00154416853572
ko04371	Apelin signaling pathway	45/1169	177/7206	0.00179351749423
ko00590	Arachidonic acid metabolism	1/1169	52/7206	0.00198554891833
ko05166	HTLV-I infection	29/1169	292/7206	0.00203059930152
ko04915	Estrogen signaling pathway	35/1169	131/7206	0.00251164058537
ko04214	Apoptosis - fly	3/1169	72/7206	0.00324190901921
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1169	14/7206	0.00347439124307
ko03420	Nucleotide excision repair	1/1169	46/7206	0.00444199219096
ko04922	Glucagon signaling pathway	33/1169	128/7206	0.00508548618582
ko04630	Jak-STAT signaling pathway	10/1169	132/7206	0.0056893201044
ko05321	Inflammatory bowel disease (IBD)	2/1169	56/7206	0.00571966804281
ko04072	Phospholipase D signaling pathway	47/1169	197/7206	0.00578297153176
ko03022	Basal transcription factors	1/1169	44/7206	0.00668363368176
ko05144	Malaria	1/1169	45/7206	0.00690409362169
ko00071	Fatty acid degradation	1/1169	45/7206	0.00690409362169
ko03018	RNA degradation	5/1169	84/7206	0.00696884220973
ko01524	Platinum drug resistance	4/1169	76/7206	0.00701683611156
ko04668	TNF signaling pathway	9/1169	120/7206	0.00814484320452
ko00240	Pyrimidine metabolism	8/1169	110/7206	0.00858045771633
ko05131	Shigellosis	5/1169	82/7206	0.00972109718591
ko00310	Lysine degradation	4/1169	73/7206	0.00977254068958
ko05145	Toxoplasmosis	10/1169	126/7206	0.00988494379818
ko04923	Regulation of lipolysis in adipocytes	21/1169	77/7206	0.0122752189998
ko04622	RIG-I-like receptor signaling pathway	3/1169	62/7206	0.0138386720206
ko00630	Glyoxylate and dicarboxylate metabolism	1/1169	38/7206	0.0149850924759
ko03410	Base excision repair	1/1169	38/7206	0.0149850924759
ko05219	Bladder cancer	2/1169	48/7206	0.0176430543692
ko04912	GnRH signaling pathway	30/1169	122/7206	0.017752357878
ko04933	AGE-RAGE signaling pathway in diabetic complications	12/1169	135/7206	0.0179661715217
ko04657	IL-17 signaling pathway	6/1169	87/7206	0.0180111682263
ko05133	Pertussis	6/1169	87/7206	0.0180111682263
ko05215	Prostate cancer	9/1169	111/7206	0.0187212347654
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1169	100/7206	0.0202513318889
ko05418	Fluid shear stress and atherosclerosis	17/1169	173/7206	0.021099045257
ko04210	Apoptosis	18/1169	180/7206	0.0236525911899
ko05212	Pancreatic cancer	6/1169	83/7206	0.0237904215537
ko04115	p53 signaling pathway	5/1169	74/7206	0.0253311649418
ko04640	Hematopoietic cell lineage	4/1169	64/7206	0.0262367779728
ko04930	Type II diabetes mellitus	15/1169	54/7206	0.0262833338288
ko04620	Toll-like receptor signaling pathway	8/1169	100/7206	0.0275791508954
ko04070	Phosphatidylinositol signaling system	27/1169	112/7206	0.0276884733011
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1169	92/7206	0.0313427957985
ko05010	Alzheimer's disease	44/1169	202/7206	0.0331771763547
ko00860	Porphyrin and chlorophyll metabolism	1/1169	34/7206	0.0334397519242
ko04658	Th1 and Th2 cell differentiation	8/1169	96/7206	0.0356235019207
ko04114	Oocyte meiosis	32/1169	139/7206	0.0357169389445
ko04330	Notch signaling pathway	4/1169	62/7206	0.0364722288058
ko00561	Glycerolipid metabolism	4/1169	63/7206	0.0372358766309
ko00600	Sphingolipid metabolism	4/1169	63/7206	0.0372358766309
ko04015	Rap1 signaling pathway	58/1169	278/7206	0.0377272213976
ko00280	Valine, leucine and isoleucine degradation	3/1169	54/7206	0.0388066568646
ko04217	Necroptosis	19/1169	178/7206	0.0397262005496
ko04140	Autophagy - animal	17/1169	164/7206	0.0412409884165
ko05217	Basal cell carcinoma	5/1169	68/7206	0.046632277309
ko05206	MicroRNAs in cancer	19/1169	177/7206	0.0491643679538
ko04916	Melanogenesis	32/1169	142/7206	0.0496599643657