ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	193/1165	423/7206	1.6466380158e-49
ko04724	Glutamatergic synapse	88/1165	152/7206	2.24415476764e-32
ko05033	Nicotine addiction	47/1165	56/7206	4.93350369544e-29
ko04713	Circadian entrainment	76/1165	136/7206	1.0906097303e-26
ko05032	Morphine addiction	64/1165	110/7206	5.88179985916e-24
ko04727	GABAergic synapse	63/1165	110/7206	4.38222982113e-23
ko04721	Synaptic vesicle cycle	52/1165	80/7206	7.49855595513e-23
ko04728	Dopaminergic synapse	86/1165	185/7206	1.01841896536e-22
ko04725	Cholinergic synapse	75/1165	160/7206	3.33111855229e-20
ko04024	cAMP signaling pathway	102/1165	279/7206	2.93740115107e-17
ko04723	Retrograde endocannabinoid signaling	74/1165	175/7206	8.20748198349e-17
ko04020	Calcium signaling pathway	95/1165	265/7206	2.12523964995e-15
ko04742	Taste transduction	37/1165	61/7206	3.5433578053e-15
ko04921	Oxytocin signaling pathway	80/1165	209/7206	6.58863911672e-15
ko04744	Phototransduction	27/1165	36/7206	7.04820084801e-15
ko04726	Serotonergic synapse	60/1165	137/7206	1.08582834421e-14
ko04911	Insulin secretion	54/1165	117/7206	1.62493915735e-14
ko04720	Long-term potentiation	47/1165	99/7206	2.29407070506e-13
ko05031	Amphetamine addiction	43/1165	91/7206	2.98345528394e-12
ko04970	Salivary secretion	44/1165	95/7206	3.94701865753e-12
ko04261	Adrenergic signaling in cardiomyocytes	72/1165	205/7206	1.54975735419e-11
ko04740	Olfactory transduction	38/1165	80/7206	4.58104216802e-11
ko03040	Spliceosome	1/1165	145/7206	3.15410222626e-10
ko04360	Axon guidance	74/1165	233/7206	1.91154349135e-09
ko04060	Cytokine-cytokine receptor interaction	6/1165	191/7206	1.14917914694e-08
ko05203	Viral carcinogenesis	14/1165	277/7206	1.44276369475e-08
ko04925	Aldosterone synthesis and secretion	40/1165	105/7206	4.86438352092e-08
ko05168	Herpes simplex infection	6/1165	182/7206	5.6401104585e-08
ko04971	Gastric acid secretion	37/1165	98/7206	1.9965296244e-07
ko05030	Cocaine addiction	30/1165	73/7206	2.95790087886e-07
ko05164	Influenza A	6/1165	167/7206	3.57491896886e-07
ko04924	Renin secretion	33/1165	86/7206	7.49904385388e-07
ko04120	Ubiquitin mediated proteolysis	4/1165	138/7206	9.59190336999e-07
ko04540	Gap junction	43/1165	128/7206	1.17080970778e-06
ko04022	cGMP-PKG signaling pathway	63/1165	216/7206	1.17604775787e-06
ko04621	NOD-like receptor signaling pathway	6/1165	157/7206	1.59660651479e-06
ko04966	Collecting duct acid secretion	15/1165	26/7206	1.62563941501e-06
ko03013	RNA transport	7/1165	166/7206	1.90927365007e-06
ko04730	Long-term depression	30/1165	78/7206	2.57633073389e-06
ko04010	MAPK signaling pathway	83/1165	321/7206	5.73013433679e-06
ko04745	Phototransduction - fly	18/1165	38/7206	6.54415122217e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1165	74/7206	7.14800460116e-06
ko05322	Systemic lupus erythematosus	7/1165	151/7206	1.64222459624e-05
ko04260	Cardiac muscle contraction	33/1165	98/7206	1.98460898163e-05
ko04610	Complement and coagulation cascades	1/1165	79/7206	2.0534619937e-05
ko05169	Epstein-Barr virus infection	13/1165	206/7206	2.93350086113e-05
ko04514	Cell adhesion molecules (CAMs)	40/1165	130/7206	3.05916688675e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1165	79/7206	3.51595788394e-05
ko04972	Pancreatic secretion	35/1165	111/7206	6.80443606881e-05
ko04070	Phosphatidylinositol signaling system	35/1165	112/7206	7.32968000101e-05
ko04141	Protein processing in endoplasmic reticulum	12/1165	184/7206	0.000102010941094
ko04110	Cell cycle	8/1165	145/7206	0.00013972203283
ko04626	Plant-pathogen interaction	10/1165	18/7206	0.000147271877415
ko03008	Ribosome biogenesis in eukaryotes	2/1165	79/7206	0.000172909642288
ko04014	Ras signaling pathway	69/1165	279/7206	0.000173102896839
ko05110	Vibrio cholerae infection	22/1165	63/7206	0.000222041013716
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1165	59/7206	0.000241323659309
ko05162	Measles	6/1165	120/7206	0.000246284176952
ko04964	Proximal tubule bicarbonate reclamation	13/1165	29/7206	0.000256095264722
ko04612	Antigen processing and presentation	2/1165	77/7206	0.000257451824837
ko04976	Bile secretion	26/1165	80/7206	0.00031314501915
ko05414	Dilated cardiomyopathy	33/1165	112/7206	0.000386029240619
ko05140	Leishmaniasis	2/1165	75/7206	0.000387019304509
ko04064	NF-kappa B signaling pathway	4/1165	96/7206	0.000405218885319
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1165	14/7206	0.000547392393493
ko05205	Proteoglycans in cancer	25/1165	271/7206	0.000990999188325
ko04750	Inflammatory mediator regulation of TRP channels	34/1165	122/7206	0.00108324557184
ko05161	Hepatitis B	13/1165	173/7206	0.00108403705257
ko05166	HTLV-I infection	28/1165	292/7206	0.00114519189735
ko04146	Peroxisome	4/1165	89/7206	0.0012092722191
ko00480	Glutathione metabolism	1/1165	55/7206	0.00133583718481
ko04371	Apelin signaling pathway	44/1165	177/7206	0.00256007328593
ko04214	Apoptosis - fly	3/1165	72/7206	0.00322257810664
ko00240	Pyrimidine metabolism	7/1165	110/7206	0.00367414375072
ko04915	Estrogen signaling pathway	34/1165	131/7206	0.00376950504593
ko04072	Phospholipase D signaling pathway	47/1165	197/7206	0.0043122963406
ko03420	Nucleotide excision repair	1/1165	46/7206	0.00445983373016
ko04657	IL-17 signaling pathway	5/1165	87/7206	0.00502019369612
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1165	182/7206	0.0055867842423
ko04630	Jak-STAT signaling pathway	10/1165	132/7206	0.00564346842941
ko05321	Inflammatory bowel disease (IBD)	2/1165	56/7206	0.00573074427082
ko03022	Basal transcription factors	1/1165	44/7206	0.00668881620649
ko00071	Fatty acid degradation	1/1165	45/7206	0.0068722509111
ko01524	Platinum drug resistance	4/1165	76/7206	0.00698546105416
ko03018	RNA degradation	5/1165	84/7206	0.00698659336748
ko04668	TNF signaling pathway	9/1165	120/7206	0.00808765460561
ko00562	Inositol phosphate metabolism	24/1165	89/7206	0.00857028349734
ko04912	GnRH signaling pathway	31/1165	122/7206	0.0086299736511
ko04640	Hematopoietic cell lineage	3/1165	64/7206	0.00945052541516
ko00310	Lysine degradation	4/1165	73/7206	0.00974873439709
ko05145	Toxoplasmosis	10/1165	126/7206	0.00984021135649
ko04922	Glucagon signaling pathway	32/1165	128/7206	0.01033412469
ko05418	Fluid shear stress and atherosclerosis	16/1165	173/7206	0.0116760792424
ko04923	Regulation of lipolysis in adipocytes	21/1165	77/7206	0.0120314171599
ko00590	Arachidonic acid metabolism	2/1165	52/7206	0.0124377469251
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1165	100/7206	0.0128711275426
ko04217	Necroptosis	17/1165	178/7206	0.0131422378549
ko00330	Arginine and proline metabolism	3/1165	61/7206	0.0133487066418
ko04622	RIG-I-like receptor signaling pathway	3/1165	62/7206	0.0137458321643
ko00260	Glycine, serine and threonine metabolism	2/1165	48/7206	0.0176817179706
ko04270	Vascular smooth muscle contraction	36/1165	154/7206	0.0195212999751
ko04350	TGF-beta signaling pathway	8/1165	103/7206	0.0208305680016
ko00630	Glyoxylate and dicarboxylate metabolism	1/1165	38/7206	0.0237455635903
ko03410	Base excision repair	1/1165	38/7206	0.0237455635903
ko00910	Nitrogen metabolism	7/1165	19/7206	0.0239023748518
ko04115	p53 signaling pathway	5/1165	74/7206	0.025302385907
ko05144	Malaria	2/1165	45/7206	0.0256480517213
ko04930	Type II diabetes mellitus	15/1165	54/7206	0.0257943890093
ko04620	Toll-like receptor signaling pathway	8/1165	100/7206	0.027424154059
ko04916	Melanogenesis	33/1165	142/7206	0.0279164012236
ko05222	Small cell lung cancer	7/1165	89/7206	0.0294886432281
ko05034	Alcoholism	51/1165	238/7206	0.0311710591072
ko05214	Glioma	20/1165	79/7206	0.031425642188
ko05131	Shigellosis	6/1165	82/7206	0.0329897497208
ko00860	Porphyrin and chlorophyll metabolism	1/1165	34/7206	0.0334213212684
ko04142	Lysosome	15/1165	151/7206	0.0336999292873
ko00500	Starch and sucrose metabolism	1/1165	35/7206	0.034513484341
ko04658	Th1 and Th2 cell differentiation	8/1165	96/7206	0.035592713044
ko04330	Notch signaling pathway	4/1165	62/7206	0.0364452855344
ko00600	Sphingolipid metabolism	4/1165	63/7206	0.0370813909466
ko04015	Rap1 signaling pathway	58/1165	278/7206	0.0373308937744
ko05215	Prostate cancer	10/1165	111/7206	0.0374272364231
ko00280	Valine, leucine and isoleucine degradation	3/1165	54/7206	0.0386171551281
ko05133	Pertussis	7/1165	87/7206	0.0393079667116
ko04140	Autophagy - animal	17/1165	164/7206	0.0412261788058
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1165	92/7206	0.0464237449333
ko05217	Basal cell carcinoma	5/1165	68/7206	0.0466709231694
ko05016	Huntington's disease	24/1165	215/7206	0.0476596404631