ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	189/1107	423/7206	2.42983906148e-50
ko04724	Glutamatergic synapse	83/1107	152/7206	9.77566719414e-30
ko05033	Nicotine addiction	46/1107	56/7206	1.25453062585e-28
ko05032	Morphine addiction	64/1107	110/7206	3.13944162954e-25
ko04721	Synaptic vesicle cycle	53/1107	80/7206	5.87558342472e-25
ko04713	Circadian entrainment	71/1107	136/7206	5.39248193633e-24
ko04727	GABAergic synapse	62/1107	110/7206	1.90468964444e-23
ko04725	Cholinergic synapse	75/1107	160/7206	1.41550834838e-21
ko04728	Dopaminergic synapse	82/1107	185/7206	1.56998927934e-21
ko04723	Retrograde endocannabinoid signaling	74/1107	175/7206	4.28401508527e-18
ko04024	cAMP signaling pathway	96/1107	279/7206	7.45020845255e-16
ko04911	Insulin secretion	54/1107	117/7206	1.73836792179e-15
ko04726	Serotonergic synapse	59/1107	137/7206	4.28573673942e-15
ko04020	Calcium signaling pathway	91/1107	265/7206	5.31753224161e-15
ko04742	Taste transduction	36/1107	61/7206	5.49148997432e-15
ko04921	Oxytocin signaling pathway	76/1107	209/7206	4.77697649058e-14
ko04261	Adrenergic signaling in cardiomyocytes	70/1107	205/7206	1.12720961133e-11
ko04720	Long-term potentiation	43/1107	99/7206	1.70477469434e-11
ko05031	Amphetamine addiction	40/1107	91/7206	5.56960231678e-11
ko04970	Salivary secretion	40/1107	95/7206	2.77403362003e-10
ko03040	Spliceosome	1/1107	145/7206	1.38193120659e-09
ko04744	Phototransduction	21/1107	36/7206	3.782795827e-09
ko05203	Viral carcinogenesis	13/1107	277/7206	2.0496187388e-08
ko04360	Axon guidance	69/1107	233/7206	2.71878486026e-08
ko05168	Herpes simplex infection	5/1107	182/7206	3.03786519044e-08
ko04971	Gastric acid secretion	36/1107	98/7206	2.21996190571e-07
ko04060	Cytokine-cytokine receptor interaction	7/1107	191/7206	2.34281352721e-07
ko04740	Olfactory transduction	31/1107	80/7206	2.78303073741e-07
ko04540	Gap junction	43/1107	128/7206	3.19076960128e-07
ko04925	Aldosterone synthesis and secretion	37/1107	105/7206	3.68208593068e-07
ko04924	Renin secretion	32/1107	86/7206	5.30070312787e-07
ko04966	Collecting duct acid secretion	15/1107	26/7206	8.28434665434e-07
ko04022	cGMP-PKG signaling pathway	61/1107	216/7206	1.11237911699e-06
ko05030	Cocaine addiction	28/1107	73/7206	1.3349527704e-06
ko04010	MAPK signaling pathway	82/1107	321/7206	1.57580825486e-06
ko04730	Long-term depression	29/1107	78/7206	1.83631008045e-06
ko04120	Ubiquitin mediated proteolysis	4/1107	138/7206	3.50379294014e-06
ko04514	Cell adhesion molecules (CAMs)	40/1107	130/7206	6.92189838798e-06
ko03013	RNA transport	7/1107	166/7206	9.20084167711e-06
ko05322	Systemic lupus erythematosus	6/1107	151/7206	1.09161474192e-05
ko04260	Cardiac muscle contraction	32/1107	98/7206	1.47736768646e-05
ko04745	Phototransduction - fly	17/1107	38/7206	1.51595868219e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1107	74/7206	2.4318415199e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1107	79/7206	2.67690163597e-05
ko05164	Influenza A	8/1107	167/7206	2.80022444725e-05
ko04014	Ras signaling pathway	69/1107	279/7206	2.95620499941e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1107	59/7206	3.03448509296e-05
ko04610	Complement and coagulation cascades	1/1107	79/7206	5.2220857087e-05
ko05169	Epstein-Barr virus infection	13/1107	206/7206	7.8002000063e-05
ko04626	Plant-pathogen interaction	10/1107	18/7206	9.43602753942e-05
ko04972	Pancreatic secretion	33/1107	111/7206	9.64755658415e-05
ko05110	Vibrio cholerae infection	22/1107	63/7206	0.000122351352602
ko04621	NOD-like receptor signaling pathway	9/1107	157/7206	0.000291840600675
ko05414	Dilated cardiomyopathy	32/1107	112/7206	0.000300164485758
ko04070	Phosphatidylinositol signaling system	32/1107	112/7206	0.000300164485758
ko04141	Protein processing in endoplasmic reticulum	12/1107	184/7206	0.000375197372525
ko04110	Cell cycle	8/1107	145/7206	0.000406486366052
ko03008	Ribosome biogenesis in eukaryotes	2/1107	79/7206	0.000412490817924
ko05140	Leishmaniasis	2/1107	75/7206	0.000596627646915
ko05162	Measles	6/1107	120/7206	0.000754967838388
ko04976	Bile secretion	24/1107	80/7206	0.000833035679239
ko04750	Inflammatory mediator regulation of TRP channels	33/1107	122/7206	0.000843640521435
ko04072	Phospholipase D signaling pathway	48/1107	197/7206	0.000857830802705
ko04064	NF-kappa B signaling pathway	4/1107	96/7206	0.000884430623718
ko04915	Estrogen signaling pathway	34/1107	131/7206	0.00137749147807
ko00480	Glutathione metabolism	1/1107	55/7206	0.00209540996552
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1107	14/7206	0.00251677469153
ko04964	Proximal tubule bicarbonate reclamation	11/1107	29/7206	0.00256096074797
ko04146	Peroxisome	4/1107	89/7206	0.00263976786263
ko04640	Hematopoietic cell lineage	2/1107	64/7206	0.00279084798776
ko04371	Apelin signaling pathway	42/1107	177/7206	0.00296893306395
ko00590	Arachidonic acid metabolism	1/1107	52/7206	0.00311445656275
ko05205	Proteoglycans in cancer	25/1107	271/7206	0.00337978054818
ko05161	Hepatitis B	14/1107	173/7206	0.0053534331965
ko00330	Arginine and proline metabolism	2/1107	61/7206	0.006309780062
ko03420	Nucleotide excision repair	1/1107	46/7206	0.00692916445233
ko04912	GnRH signaling pathway	30/1107	122/7206	0.00732752088468
ko00260	Glycine, serine and threonine metabolism	1/1107	48/7206	0.00738386128283
ko05166	HTLV-I infection	29/1107	292/7206	0.00781848235751
ko04015	Rap1 signaling pathway	59/1107	278/7206	0.00830414358489
ko05321	Inflammatory bowel disease (IBD)	2/1107	56/7206	0.00866300829251
ko01524	Platinum drug resistance	4/1107	76/7206	0.0100092047664
ko04630	Jak-STAT signaling pathway	10/1107	132/7206	0.010104365191
ko04612	Antigen processing and presentation	4/1107	77/7206	0.0101150992073
ko03022	Basal transcription factors	1/1107	44/7206	0.0104282985309
ko05144	Malaria	1/1107	45/7206	0.0108175885869
ko00071	Fatty acid degradation	1/1107	45/7206	0.0108175885869
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1107	100/7206	0.0112354192157
ko00280	Valine, leucine and isoleucine degradation	2/1107	54/7206	0.0126334788714
ko03018	RNA degradation	5/1107	84/7206	0.013931401634
ko00310	Lysine degradation	4/1107	73/7206	0.0139834266481
ko00240	Pyrimidine metabolism	8/1107	110/7206	0.0157956094602
ko04923	Regulation of lipolysis in adipocytes	20/1107	77/7206	0.0158203654531
ko04270	Vascular smooth muscle contraction	35/1107	154/7206	0.0169761772356
ko05145	Toxoplasmosis	10/1107	126/7206	0.017424857633
ko05131	Shigellosis	5/1107	82/7206	0.019466201442
ko04330	Notch signaling pathway	3/1107	62/7206	0.0197575951549
ko04622	RIG-I-like receptor signaling pathway	3/1107	62/7206	0.0197575951549
ko04214	Apoptosis - fly	4/1107	72/7206	0.0199222009639
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1107	182/7206	0.0215749042197
ko04658	Th1 and Th2 cell differentiation	7/1107	96/7206	0.0227135426392
ko03410	Base excision repair	1/1107	38/7206	0.0229524296435
ko04657	IL-17 signaling pathway	6/1107	87/7206	0.0243825031846
ko05133	Pertussis	6/1107	87/7206	0.0243825031846
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1107	40/7206	0.0244246949079
ko04916	Melanogenesis	32/1107	142/7206	0.0246273121763
ko00380	Tryptophan metabolism	2/1107	50/7206	0.0275647357915
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1107	92/7206	0.0283332529965
ko05231	Choline metabolism in cancer	30/1107	134/7206	0.0288613265328
ko04668	TNF signaling pathway	10/1107	120/7206	0.0295704610164
ko04115	p53 signaling pathway	5/1107	74/7206	0.03523451221
ko00982	Drug metabolism - cytochrome P450	1/1107	37/7206	0.0356357346557
ko04620	Toll-like receptor signaling pathway	8/1107	100/7206	0.0363875103812
ko04930	Type II diabetes mellitus	14/1107	54/7206	0.0371625914839
ko00620	Pyruvate metabolism	2/1107	46/7206	0.0380618419542
ko00270	Cysteine and methionine metabolism	2/1107	47/7206	0.0391555672836
ko05214	Glioma	19/1107	79/7206	0.040117040829
ko05418	Fluid shear stress and atherosclerosis	17/1107	173/7206	0.0421198869042
ko05034	Alcoholism	48/1107	238/7206	0.0437862045569
ko04071	Sphingolipid signaling pathway	34/1107	162/7206	0.0476176283868