ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 35/310 191/7206 1.35555552504e-13 ko05340 Primary immunodeficiency 14/310 30/7206 4.34522232881e-12 ko04380 Osteoclast differentiation 27/310 134/7206 9.75299634496e-12 ko05140 Leishmaniasis 19/310 75/7206 2.03494500768e-10 ko05145 Toxoplasmosis 24/310 126/7206 4.95581836176e-10 ko04650 Natural killer cell mediated cytotoxicity 21/310 97/7206 5.29457919568e-10 ko05321 Inflammatory bowel disease (IBD) 16/310 56/7206 8.1846146309e-10 ko05150 Staphylococcus aureus infection 13/310 36/7206 1.27413924563e-09 ko04612 Antigen processing and presentation 18/310 77/7206 2.53723317477e-09 ko04640 Hematopoietic cell lineage 16/310 64/7206 7.01563105963e-09 ko05164 Influenza A 26/310 167/7206 8.50555875033e-09 ko04659 Th17 cell differentiation 20/310 106/7206 1.72160814733e-08 ko05152 Tuberculosis 27/310 187/7206 2.29386666134e-08 ko05162 Measles 21/310 120/7206 3.01443056194e-08 ko04610 Complement and coagulation cascades 16/310 79/7206 1.72061941087e-07 ko04621 NOD-like receptor signaling pathway 23/310 157/7206 2.0107103776e-07 ko05168 Herpes simplex infection 25/310 182/7206 2.10006883737e-07 ko05330 Allograft rejection 9/310 24/7206 3.32106961405e-07 ko04620 Toll-like receptor signaling pathway 17/310 100/7206 9.88449743221e-07 ko04672 Intestinal immune network for IgA production 10/310 37/7206 2.32242960004e-06 ko04658 Th1 and Th2 cell differentiation 16/310 96/7206 2.71566315424e-06 ko04064 NF-kappa B signaling pathway 16/310 96/7206 2.71566315424e-06 ko04630 Jak-STAT signaling pathway 19/310 132/7206 3.1174887359e-06 ko05310 Asthma 7/310 17/7206 3.41659971066e-06 ko04660 T cell receptor signaling pathway 18/310 124/7206 5.03585526104e-06 ko04145 Phagosome 21/310 162/7206 5.23227484434e-06 ko05332 Graft-versus-host disease 7/310 18/7206 5.38593910428e-06 ko05144 Malaria 10/310 45/7206 1.56495661818e-05 ko05320 Autoimmune thyroid disease 8/310 29/7206 2.08384895484e-05 ko04622 RIG-I-like receptor signaling pathway 11/310 62/7206 5.56517105905e-05 ko04217 Necroptosis 20/310 178/7206 7.24492710573e-05 ko04662 B cell receptor signaling pathway 13/310 88/7206 8.76210464299e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 20/310 191/7206 0.000192685522949 ko04611 Platelet activation 18/310 163/7206 0.0002072085316 ko05133 Pertussis 12/310 87/7206 0.000316382596722 ko04940 Type I diabetes mellitus 7/310 32/7206 0.000338520814202 ko05161 Hepatitis B 18/310 173/7206 0.000433913337857 ko05142 Chagas disease (American trypanosomiasis) 15/310 130/7206 0.000434501141132 ko05034 Alcoholism 1/310 238/7206 0.00050411586654 ko04062 Chemokine signaling pathway 20/310 201/7206 0.00050863395554 ko00120 Primary bile acid biosynthesis 5/310 20/7206 0.00129665413393 ko04514 Cell adhesion molecules (CAMs) 14/310 130/7206 0.00133064840741 ko05323 Rheumatoid arthritis 11/310 89/7206 0.00142128843037 ko04664 Fc epsilon RI signaling pathway 10/310 77/7206 0.00158890774715 ko04666 Fc gamma R-mediated phagocytosis 13/310 122/7206 0.00215727944407 ko05416 Viral myocarditis 8/310 55/7206 0.00223192919991 ko05166 HTLV-I infection 23/310 292/7206 0.0046005225928 ko04310 Wnt signaling pathway 1/310 181/7206 0.00489954820214 ko00590 Arachidonic acid metabolism 7/310 52/7206 0.00644833905986 ko04670 Leukocyte transendothelial migration 14/310 151/7206 0.00656330743897 ko05160 Hepatitis C 14/310 153/7206 0.00711436049925 ko04623 Cytosolic DNA-sensing pathway 6/310 41/7206 0.00761037533135 ko05132 Salmonella infection 10/310 98/7206 0.00918162521693 ko05418 Fluid shear stress and atherosclerosis 14/310 173/7206 0.0208008014061 ko04137 Mitophagy - animal 8/310 82/7206 0.0241197493449 ko04390 Hippo signaling pathway 2/310 188/7206 0.0260698397895 ko03050 Proteasome 6/310 54/7206 0.0275030556688 ko04072 Phospholipase D signaling pathway 15/310 197/7206 0.0302179848882 ko04713 Circadian entrainment 1/310 136/7206 0.0311529852807 ko05224 Breast cancer 2/310 174/7206 0.0352077751139 ko04210 Apoptosis 14/310 180/7206 0.0371601600426 ko04668 TNF signaling pathway 10/310 120/7206 0.0383200227098 ko05146 Amoebiasis 9/310 99/7206 0.0386094295764 ko05134 Legionellosis 7/310 74/7206 0.0391089864687 ko01524 Platinum drug resistance 7/310 76/7206 0.0442245440785 ko03010 Ribosome 1/310 129/7206 0.0453055009005 ko00592 alpha-Linolenic acid metabolism 3/310 19/7206 0.0458436097012 ko04360 Axon guidance 4/310 233/7206 0.0474590668879 ko04152 AMPK signaling pathway 2/310 161/7206 0.0487023753932