ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	188/1144	423/7206	2.53745675284e-47
ko04724	Glutamatergic synapse	84/1144	152/7206	1.58800612698e-29
ko05033	Nicotine addiction	46/1144	56/7206	5.53377798446e-28
ko05032	Morphine addiction	67/1144	110/7206	3.73725247093e-27
ko04713	Circadian entrainment	72/1144	136/7206	6.52851797356e-24
ko04727	GABAergic synapse	63/1144	110/7206	1.58393249191e-23
ko04728	Dopaminergic synapse	82/1144	185/7206	1.38495089724e-20
ko04725	Cholinergic synapse	74/1144	160/7206	5.33640924967e-20
ko04723	Retrograde endocannabinoid signaling	75/1144	175/7206	6.92852771022e-18
ko04020	Calcium signaling pathway	96/1144	265/7206	1.40157224246e-16
ko04024	cAMP signaling pathway	98/1144	279/7206	8.29792064302e-16
ko04911	Insulin secretion	55/1144	117/7206	1.51856928396e-15
ko04721	Synaptic vesicle cycle	43/1144	80/7206	4.53293808479e-15
ko04742	Taste transduction	36/1144	61/7206	1.57775788328e-14
ko04726	Serotonergic synapse	58/1144	137/7206	8.18799924486e-14
ko04744	Phototransduction	25/1144	36/7206	8.42439863319e-13
ko04921	Oxytocin signaling pathway	74/1144	209/7206	1.92727022901e-12
ko03040	Spliceosome	1/1144	145/7206	5.14464601152e-10
ko04261	Adrenergic signaling in cardiomyocytes	68/1144	205/7206	6.23952515707e-10
ko05031	Amphetamine addiction	38/1144	91/7206	2.70477738677e-09
ko04360	Axon guidance	72/1144	233/7206	5.00686603406e-09
ko04970	Salivary secretion	38/1144	95/7206	1.13682068079e-08
ko04720	Long-term potentiation	39/1144	99/7206	1.2131016728e-08
ko03013	RNA transport	5/1144	166/7206	1.33101651375e-07
ko05322	Systemic lupus erythematosus	4/1144	151/7206	2.08795005352e-07
ko05203	Viral carcinogenesis	17/1144	277/7206	8.66995366535e-07
ko04971	Gastric acid secretion	35/1144	98/7206	1.87137874714e-06
ko04010	MAPK signaling pathway	83/1144	321/7206	2.35986310554e-06
ko04925	Aldosterone synthesis and secretion	36/1144	105/7206	2.61305797522e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1144	74/7206	3.57729807002e-06
ko04972	Pancreatic secretion	37/1144	111/7206	4.67532414399e-06
ko04070	Phosphatidylinositol signaling system	37/1144	112/7206	5.52921578179e-06
ko04022	cGMP-PKG signaling pathway	60/1144	216/7206	6.73548532784e-06
ko04740	Olfactory transduction	29/1144	80/7206	7.42310561446e-06
ko04060	Cytokine-cytokine receptor interaction	10/1144	191/7206	7.61004637034e-06
ko05030	Cocaine addiction	27/1144	73/7206	1.18526848687e-05
ko05164	Influenza A	8/1144	167/7206	1.33619033709e-05
ko04072	Phospholipase D signaling pathway	54/1144	197/7206	2.73576522186e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1144	79/7206	3.27102670747e-05
ko04621	NOD-like receptor signaling pathway	8/1144	157/7206	5.41857182832e-05
ko04730	Long-term depression	27/1144	78/7206	5.56873525459e-05
ko05168	Herpes simplex infection	11/1144	182/7206	7.81926773521e-05
ko04514	Cell adhesion molecules (CAMs)	38/1144	130/7206	0.000133761467722
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1144	79/7206	0.00014574228819
ko04750	Inflammatory mediator regulation of TRP channels	35/1144	122/7206	0.000377913352085
ko04745	Phototransduction - fly	15/1144	38/7206	0.000387842993402
ko04612	Antigen processing and presentation	2/1144	77/7206	0.000406748348063
ko04141	Protein processing in endoplasmic reticulum	13/1144	184/7206	0.000458711417228
ko04120	Ubiquitin mediated proteolysis	8/1144	138/7206	0.000548973611172
ko04014	Ras signaling pathway	66/1144	279/7206	0.000572250438851
ko05414	Dilated cardiomyopathy	32/1144	112/7206	0.000592281333347
ko04260	Cardiac muscle contraction	29/1144	98/7206	0.000664994600685
ko04540	Gap junction	35/1144	128/7206	0.000855324724507
ko04966	Collecting duct acid secretion	11/1144	26/7206	0.00118001341784
ko04930	Type II diabetes mellitus	18/1144	54/7206	0.00123523754489
ko04610	Complement and coagulation cascades	3/1144	79/7206	0.0015982840612
ko04924	Renin secretion	25/1144	86/7206	0.00165373801181
ko04976	Bile secretion	24/1144	80/7206	0.00169158509545
ko05133	Pertussis	4/1144	87/7206	0.0017363402566
ko04110	Cell cycle	10/1144	145/7206	0.00176241810128
ko04711	Circadian rhythm - fly	7/1144	13/7206	0.00177010292366
ko00590	Arachidonic acid metabolism	1/1144	52/7206	0.00200627398317
ko05140	Leishmaniasis	3/1144	75/7206	0.00222632479057
ko04710	Circadian rhythm	15/1144	43/7206	0.00231785572034
ko05205	Proteoglycans in cancer	26/1144	271/7206	0.00293443379506
ko00562	Inositol phosphate metabolism	25/1144	89/7206	0.00312185585477
ko04964	Proximal tubule bicarbonate reclamation	11/1144	29/7206	0.00334457682682
ko05162	Measles	8/1144	120/7206	0.00350596024869
ko05169	Epstein-Barr virus infection	18/1144	206/7206	0.0035215266407
ko04960	Aldosterone-regulated sodium reabsorption	14/1144	41/7206	0.00390089960976
ko00330	Arginine and proline metabolism	2/1144	61/7206	0.00408305609052
ko04923	Regulation of lipolysis in adipocytes	22/1144	77/7206	0.00427384087135
ko00260	Glycine, serine and threonine metabolism	1/1144	48/7206	0.00457801991939
ko04146	Peroxisome	5/1144	89/7206	0.00510562276475
ko05016	Huntington's disease	20/1144	215/7206	0.00585716275533
ko05144	Malaria	1/1144	45/7206	0.00679647724815
ko00071	Fatty acid degradation	1/1144	45/7206	0.00679647724815
ko03022	Basal transcription factors	1/1144	44/7206	0.00680154233647
ko04064	NF-kappa B signaling pathway	6/1144	96/7206	0.00701568225107
ko00620	Pyruvate metabolism	1/1144	46/7206	0.00702533821315
ko03420	Nucleotide excision repair	1/1144	46/7206	0.00702533821315
ko05231	Choline metabolism in cancer	33/1144	134/7206	0.00819973151839
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1144	100/7206	0.0083505216485
ko00280	Valine, leucine and isoleucine degradation	2/1144	54/7206	0.00848462194743
ko00480	Glutathione metabolism	2/1144	55/7206	0.00852447160303
ko05110	Vibrio cholerae infection	18/1144	63/7206	0.00897946945651
ko03018	RNA degradation	5/1144	84/7206	0.00989683482348
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1144	59/7206	0.0110669770001
ko00240	Pyrimidine metabolism	8/1144	110/7206	0.0117480821432
ko04371	Apelin signaling pathway	41/1144	177/7206	0.0119498984302
ko04622	RIG-I-like receptor signaling pathway	3/1144	62/7206	0.0134754116142
ko05161	Hepatitis B	16/1144	173/7206	0.0149776980542
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1144	14/7206	0.0150562773306
ko04973	Carbohydrate digestion and absorption	13/1144	42/7206	0.016926993001
ko04657	IL-17 signaling pathway	6/1144	87/7206	0.0177224851117
ko01200	Carbon metabolism	11/1144	128/7206	0.0201746665222
ko04915	Estrogen signaling pathway	31/1144	131/7206	0.0209964653011
ko04071	Sphingolipid signaling pathway	37/1144	162/7206	0.0216864706045
ko03410	Base excision repair	1/1144	38/7206	0.0231707790372
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1144	182/7206	0.0235811612774
ko05145	Toxoplasmosis	11/1144	126/7206	0.0262090712139
ko05219	Bladder cancer	2/1144	48/7206	0.0266738349117
ko05131	Shigellosis	6/1144	82/7206	0.0323996117845
ko00860	Porphyrin and chlorophyll metabolism	1/1144	34/7206	0.0335437942453
ko00500	Starch and sucrose metabolism	1/1144	35/7206	0.0340098742629
ko05012	Parkinson's disease	15/1144	155/7206	0.0341076581699
ko00310	Lysine degradation	5/1144	73/7206	0.0349627350824
ko04918	Thyroid hormone synthesis	21/1144	86/7206	0.0367594604643
ko04217	Necroptosis	18/1144	178/7206	0.0370378231787
ko04640	Hematopoietic cell lineage	4/1144	64/7206	0.0372600718696
ko04142	Lysosome	15/1144	151/7206	0.0426813761011
ko02010	ABC transporters	11/1144	39/7206	0.0456704536869
ko04113	Meiosis - yeast	5/1144	70/7206	0.0472466688093
ko04658	Th1 and Th2 cell differentiation	8/1144	96/7206	0.0475767006771
ko04210	Apoptosis	19/1144	180/7206	0.0493857107113