ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	195/1205	423/7206	1.82383918287e-48
ko04724	Glutamatergic synapse	89/1205	152/7206	4.34138858954e-32
ko05033	Nicotine addiction	46/1205	56/7206	5.73374559261e-27
ko04713	Circadian entrainment	77/1205	136/7206	1.53486194211e-26
ko05032	Morphine addiction	67/1205	110/7206	8.75969576261e-26
ko04727	GABAergic synapse	63/1205	110/7206	2.86533598416e-22
ko04728	Dopaminergic synapse	86/1205	185/7206	1.07961922978e-21
ko04721	Synaptic vesicle cycle	51/1205	80/7206	3.51276875207e-21
ko04725	Cholinergic synapse	76/1205	160/7206	5.52722890623e-20
ko04020	Calcium signaling pathway	102/1205	265/7206	4.80173963087e-18
ko04723	Retrograde endocannabinoid signaling	76/1205	175/7206	3.56807793459e-17
ko04911	Insulin secretion	57/1205	117/7206	6.67589377077e-16
ko04024	cAMP signaling pathway	101/1205	279/7206	9.88547333445e-16
ko04726	Serotonergic synapse	62/1205	137/7206	2.97533681407e-15
ko04921	Oxytocin signaling pathway	81/1205	209/7206	9.61944490312e-15
ko04742	Taste transduction	37/1205	61/7206	1.07979906913e-14
ko04970	Salivary secretion	43/1205	95/7206	5.656019983e-11
ko05031	Amphetamine addiction	41/1205	91/7206	1.89850732701e-10
ko04261	Adrenergic signaling in cardiomyocytes	71/1205	205/7206	2.39200540329e-10
ko04720	Long-term potentiation	43/1205	99/7206	2.904971835e-10
ko03040	Spliceosome	2/1205	145/7206	1.57589442026e-09
ko04744	Phototransduction	22/1205	36/7206	2.40812802196e-09
ko04022	cGMP-PKG signaling pathway	69/1205	216/7206	2.51477943392e-08
ko05322	Systemic lupus erythematosus	5/1205	151/7206	3.83299895471e-07
ko05203	Viral carcinogenesis	18/1205	277/7206	4.06829214587e-07
ko04925	Aldosterone synthesis and secretion	39/1205	105/7206	4.20701205242e-07
ko04360	Axon guidance	69/1205	233/7206	6.51817996393e-07
ko04621	NOD-like receptor signaling pathway	6/1205	157/7206	7.04842170627e-07
ko04971	Gastric acid secretion	37/1205	98/7206	7.13890907787e-07
ko03013	RNA transport	7/1205	166/7206	8.54913732588e-07
ko05168	Herpes simplex infection	9/1205	182/7206	1.60183651169e-06
ko04966	Collecting duct acid secretion	15/1205	26/7206	2.52987521895e-06
ko04010	MAPK signaling pathway	86/1205	321/7206	3.61087311753e-06
ko04730	Long-term depression	30/1205	78/7206	3.86775044491e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1205	74/7206	4.28993180395e-06
ko04740	Olfactory transduction	30/1205	80/7206	6.41944779832e-06
ko04540	Gap junction	42/1205	128/7206	6.45562210253e-06
ko04060	Cytokine-cytokine receptor interaction	11/1205	191/7206	7.32727707061e-06
ko05030	Cocaine addiction	28/1205	73/7206	8.86179614158e-06
ko05164	Influenza A	9/1205	167/7206	1.29735396646e-05
ko04120	Ubiquitin mediated proteolysis	6/1205	138/7206	1.40358066311e-05
ko04972	Pancreatic secretion	37/1205	111/7206	1.54706519407e-05
ko04070	Phosphatidylinositol signaling system	37/1205	112/7206	1.83369703897e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1205	79/7206	4.92098225106e-05
ko04924	Renin secretion	30/1205	86/7206	5.36693339025e-05
ko04110	Cell cycle	8/1205	145/7206	6.76067922985e-05
ko04514	Cell adhesion molecules (CAMs)	40/1205	130/7206	6.83928545433e-05
ko04750	Inflammatory mediator regulation of TRP channels	38/1205	122/7206	6.95036719473e-05
ko04260	Cardiac muscle contraction	32/1205	98/7206	9.7563361737e-05
ko04610	Complement and coagulation cascades	2/1205	79/7206	0.000110781638823
ko03008	Ribosome biogenesis in eukaryotes	2/1205	79/7206	0.000110781638823
ko04014	Ras signaling pathway	71/1205	279/7206	0.000153635730543
ko04745	Phototransduction - fly	16/1205	38/7206	0.000189803743658
ko04371	Apelin signaling pathway	49/1205	177/7206	0.000209498463352
ko04064	NF-kappa B signaling pathway	4/1205	96/7206	0.000271303459829
ko05414	Dilated cardiomyopathy	34/1205	112/7206	0.000293764906245
ko04710	Circadian rhythm	17/1205	43/7206	0.000300151232254
ko04141	Protein processing in endoplasmic reticulum	14/1205	184/7206	0.00041051971277
ko04976	Bile secretion	26/1205	80/7206	0.000439391523874
ko04072	Phospholipase D signaling pathway	52/1205	197/7206	0.000459308224338
ko05110	Vibrio cholerae infection	22/1205	63/7206	0.000469789549535
ko05169	Epstein-Barr virus infection	17/1205	206/7206	0.000587652522006
ko04930	Type II diabetes mellitus	19/1205	54/7206	0.000814756128576
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1205	59/7206	0.00121823458215
ko05161	Hepatitis B	14/1205	173/7206	0.0012858301383
ko04964	Proximal tubule bicarbonate reclamation	12/1205	29/7206	0.00144428489253
ko05140	Leishmaniasis	3/1205	75/7206	0.00151484117715
ko04330	Notch signaling pathway	2/1205	62/7206	0.00175986713572
ko04612	Antigen processing and presentation	4/1205	77/7206	0.00336195943569
ko04657	IL-17 signaling pathway	5/1205	87/7206	0.00349958047556
ko04915	Estrogen signaling pathway	35/1205	131/7206	0.00420163647404
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1205	100/7206	0.0042312742787
ko05162	Measles	9/1205	120/7206	0.00431620805555
ko00071	Fatty acid degradation	1/1205	45/7206	0.00433378643529
ko03420	Nucleotide excision repair	1/1205	46/7206	0.0044560931938
ko04626	Plant-pathogen interaction	8/1205	18/7206	0.00539249045537
ko05145	Toxoplasmosis	10/1205	126/7206	0.0054082907565
ko00280	Valine, leucine and isoleucine degradation	2/1205	54/7206	0.00558284135678
ko00480	Glutathione metabolism	2/1205	55/7206	0.00564567024914
ko05321	Inflammatory bowel disease (IBD)	2/1205	56/7206	0.00588814987406
ko05205	Proteoglycans in cancer	29/1205	271/7206	0.00600596726239
ko00562	Inositol phosphate metabolism	25/1205	89/7206	0.00624285381739
ko00310	Lysine degradation	4/1205	73/7206	0.00674436681758
ko03022	Basal transcription factors	1/1205	44/7206	0.00687337042412
ko04217	Necroptosis	17/1205	178/7206	0.00793509441472
ko00590	Arachidonic acid metabolism	2/1205	52/7206	0.00818247748414
ko04922	Glucagon signaling pathway	33/1205	128/7206	0.00822966843081
ko04923	Regulation of lipolysis in adipocytes	22/1205	77/7206	0.0084137045005
ko04622	RIG-I-like receptor signaling pathway	3/1205	62/7206	0.00925772286975
ko04146	Peroxisome	6/1205	89/7206	0.00934817682148
ko05166	HTLV-I infection	33/1205	292/7206	0.0102530176482
ko00380	Tryptophan metabolism	2/1205	50/7206	0.0120553990606
ko04711	Circadian rhythm - fly	6/1205	13/7206	0.0127912646708
ko04668	TNF signaling pathway	10/1205	120/7206	0.0128990089528
ko05133	Pertussis	6/1205	87/7206	0.0129877492779
ko01524	Platinum drug resistance	5/1205	76/7206	0.0131009598836
ko00240	Pyrimidine metabolism	9/1205	110/7206	0.0138413551405
ko05131	Shigellosis	6/1205	82/7206	0.01722401999
ko03018	RNA degradation	6/1205	84/7206	0.0174993494455
ko04630	Jak-STAT signaling pathway	12/1205	132/7206	0.0178485389833
ko04960	Aldosterone-regulated sodium reabsorption	13/1205	41/7206	0.0182974840354
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1205	14/7206	0.019271883484
ko04973	Carbohydrate digestion and absorption	13/1205	42/7206	0.0206372972668
ko04270	Vascular smooth muscle contraction	37/1205	154/7206	0.0211810238332
ko04015	Rap1 signaling pathway	61/1205	278/7206	0.0214457913938
ko05214	Glioma	21/1205	79/7206	0.0228189806876
ko04916	Melanogenesis	34/1205	142/7206	0.0231473418775
ko04214	Apoptosis - fly	5/1205	72/7206	0.0249995902125
ko05144	Malaria	2/1205	45/7206	0.0254435892717
ko04210	Apoptosis	19/1205	180/7206	0.0255263237269
ko04658	Th1 and Th2 cell differentiation	8/1205	96/7206	0.0266474352376
ko04640	Hematopoietic cell lineage	4/1205	64/7206	0.0267711046969
ko00640	Propanoate metabolism	1/1205	34/7206	0.0342040081266
ko00860	Porphyrin and chlorophyll metabolism	1/1205	34/7206	0.0342040081266
ko00330	Arginine and proline metabolism	4/1205	61/7206	0.0365699535905
ko04213	Longevity regulating pathway - multiple species	22/1205	86/7206	0.0401436248922
ko04620	Toll-like receptor signaling pathway	9/1205	100/7206	0.0416914428078
ko04115	p53 signaling pathway	6/1205	74/7206	0.0423960469664
ko04142	Lysosome	16/1205	151/7206	0.0464376888868
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1205	92/7206	0.0473601717308
ko05340	Primary immunodeficiency	1/1205	30/7206	0.0486873608271
ko04912	GnRH signaling pathway	29/1205	122/7206	0.0490277204784