ko pathway ratio_in_study ratio_in_pop p_value ko00190 Oxidative phosphorylation 55/547 127/7206 4.75367875282e-29 ko05010 Alzheimer's disease 66/547 202/7206 3.71269851161e-26 ko05012 Parkinson's disease 53/547 155/7206 3.52477039792e-22 ko05016 Huntington's disease 57/547 215/7206 8.34357361656e-18 ko04260 Cardiac muscle contraction 35/547 98/7206 1.13093389409e-15 ko00020 Citrate cycle (TCA cycle) 18/547 35/7206 7.1668737262e-12 ko04932 Non-alcoholic fatty liver disease (NAFLD) 43/547 182/7206 7.9196982837e-12 ko01200 Carbon metabolism 35/547 128/7206 9.0540151111e-12 ko04974 Protein digestion and absorption 28/547 96/7206 2.20727114703e-10 ko04723 Retrograde endocannabinoid signaling 39/547 175/7206 4.98909311861e-10 ko00010 Glycolysis / Gluconeogenesis 23/547 74/7206 2.34416299773e-09 ko05410 Hypertrophic cardiomyopathy (HCM) 27/547 100/7206 3.0966241311e-09 ko04261 Adrenergic signaling in cardiomyocytes 41/547 205/7206 5.53301733562e-09 ko04512 ECM-receptor interaction 23/547 79/7206 9.63075435931e-09 ko05414 Dilated cardiomyopathy 26/547 112/7206 1.75281348134e-07 ko04060 Cytokine-cytokine receptor interaction 1/547 191/7206 9.51427711924e-06 ko04510 Focal adhesion 38/547 240/7206 1.03418867201e-05 ko00350 Tyrosine metabolism 11/547 33/7206 1.80571701876e-05 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 18/547 79/7206 1.83454583869e-05 ko00620 Pyruvate metabolism 13/547 46/7206 2.37113021305e-05 ko04964 Proximal tubule bicarbonate reclamation 10/547 29/7206 3.12250376899e-05 ko03013 RNA transport 1/547 166/7206 4.26739364331e-05 ko04020 Calcium signaling pathway 39/547 265/7206 4.73097117462e-05 ko04140 Autophagy - animal 1/547 164/7206 6.61524915365e-05 ko00710 Carbon fixation in photosynthetic organisms 9/547 27/7206 0.000106073168177 ko01230 Biosynthesis of amino acids 17/547 85/7206 0.000176968460721 ko04062 Chemokine signaling pathway 3/547 201/7206 0.000202314035488 ko04022 cGMP-PKG signaling pathway 32/547 216/7206 0.000210774985476 ko00250 Alanine, aspartate and glutamate metabolism 10/547 38/7206 0.000394916360872 ko05203 Viral carcinogenesis 7/547 277/7206 0.000443396246779 ko04120 Ubiquitin mediated proteolysis 1/547 138/7206 0.00046495641914 ko04550 Signaling pathways regulating pluripotency of stem cells 2/547 165/7206 0.000470957878103 ko04922 Glucagon signaling pathway 21/547 128/7206 0.00061991645852 ko04621 NOD-like receptor signaling pathway 2/547 157/7206 0.000652827639422 ko00680 Methane metabolism 9/547 34/7206 0.000734410522496 ko04142 Lysosome 2/547 151/7206 0.000939266743184 ko05322 Systemic lupus erythematosus 2/547 151/7206 0.000939266743184 ko04514 Cell adhesion molecules (CAMs) 21/547 130/7206 0.00109603463267 ko05161 Hepatitis B 3/547 173/7206 0.00117652663845 ko04921 Oxytocin signaling pathway 29/547 209/7206 0.00130388594139 ko03040 Spliceosome 2/547 145/7206 0.00135273809723 ko05166 HTLV-I infection 9/547 292/7206 0.00147560202981 ko04144 Endocytosis 12/547 342/7206 0.00224062465515 ko04080 Neuroactive ligand-receptor interaction 49/547 423/7206 0.00236970356363 ko05416 Viral myocarditis 11/547 55/7206 0.00241535476499 ko04978 Mineral absorption 9/547 40/7206 0.00254273952188 ko04150 mTOR signaling pathway 4/547 184/7206 0.0026655224031 ko05033 Nicotine addiction 11/547 56/7206 0.00280519370697 ko04914 Progesterone-mediated oocyte maturation 1/547 104/7206 0.00444587437468 ko04970 Salivary secretion 15/547 95/7206 0.00550003275425 ko01522 Endocrine resistance 2/547 124/7206 0.00571232409715 ko04110 Cell cycle 3/547 145/7206 0.00652805598234 ko05164 Influenza A 4/547 167/7206 0.00705495311443 ko05034 Alcoholism 8/547 238/7206 0.0086586588586 ko04614 Renin-angiotensin system 5/547 18/7206 0.00923765003169 ko04210 Apoptosis 5/547 180/7206 0.00968474253869 ko04064 NF-kappa B signaling pathway 1/547 96/7206 0.00986225018332 ko05200 Pathways in cancer 23/547 492/7206 0.0102670049995 ko04971 Gastric acid secretion 15/547 98/7206 0.0104625412422 ko04924 Renin secretion 13/547 86/7206 0.0134123017595 ko05206 MicroRNAs in cancer 5/547 177/7206 0.0134628266304 ko04917 Prolactin signaling pathway 1/547 87/7206 0.0137281000374 ko00500 Starch and sucrose metabolism 7/547 35/7206 0.0145099910277 ko01210 2-Oxocarboxylic acid metabolism 5/547 20/7206 0.0147368056689 ko05215 Prostate cancer 2/547 111/7206 0.01693365584 ko04070 Phosphatidylinositol signaling system 2/547 112/7206 0.0172671039887 ko05167 Kaposi's sarcoma-associated herpesvirus infection 6/547 191/7206 0.0174233597892 ko04068 FoxO signaling pathway 5/547 167/7206 0.0176990646784 ko04976 Bile secretion 12/547 80/7206 0.0185438897033 ko04138 Autophagy - yeast 1/547 81/7206 0.0199721464346 ko04911 Insulin secretion 16/547 117/7206 0.020209224662 ko04713 Circadian entrainment 18/547 136/7206 0.020312885537 ko05220 Chronic myeloid leukemia 1/547 85/7206 0.0206570353477 ko00630 Glyoxylate and dicarboxylate metabolism 7/547 38/7206 0.0223789032855 ko04071 Sphingolipid signaling pathway 5/547 162/7206 0.0238395949075 ko04659 Th17 cell differentiation 2/547 106/7206 0.0241030233249 ko01521 EGFR tyrosine kinase inhibitor resistance 2/547 106/7206 0.0241030233249 ko04072 Phospholipase D signaling pathway 7/547 197/7206 0.028143034808 ko04151 PI3K-Akt signaling pathway 41/547 390/7206 0.0301708896673 ko00030 Pentose phosphate pathway 6/547 32/7206 0.0309423016113 ko00643 Styrene degradation 2/547 4/7206 0.0311317266075 ko00220 Arginine biosynthesis 5/547 24/7206 0.0314567000847 ko04658 Th1 and Th2 cell differentiation 2/547 96/7206 0.032733166117 ko04620 Toll-like receptor signaling pathway 2/547 100/7206 0.0336211594354 ko04668 TNF signaling pathway 3/547 120/7206 0.0345988273449 ko04973 Carbohydrate digestion and absorption 7/547 42/7206 0.036878912158 ko04214 Apoptosis - fly 1/547 72/7206 0.0420341405925 ko04371 Apelin signaling pathway 21/547 177/7206 0.0423119963735 ko05140 Leishmaniasis 1/547 75/7206 0.0438894494095 ko05142 Chagas disease (American trypanosomiasis) 4/547 130/7206 0.0450930177788 ko04630 Jak-STAT signaling pathway 4/547 132/7206 0.0452132801327 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/547 11/7206 0.0453405512291 ko04727 GABAergic synapse 14/547 110/7206 0.0462008417448 ko04013 MAPK signaling pathway - fly 3/547 115/7206 0.0478636936005 ko05152 Tuberculosis 7/547 187/7206 0.0485099703161 ko04390 Hippo signaling pathway 7/547 188/7206 0.0489067175742