ko pathway ratio_in_study ratio_in_pop p_value ko00120 Primary bile acid biosynthesis 10/379 20/7206 1.65848148999e-08 ko00140 Steroid hormone biosynthesis 13/379 41/7206 8.81426581769e-08 ko04974 Protein digestion and absorption 19/379 96/7206 4.25246293045e-07 ko00350 Tyrosine metabolism 11/379 33/7206 5.00278553428e-07 ko00360 Phenylalanine metabolism 8/379 17/7206 8.70547157932e-07 ko05204 Chemical carcinogenesis 12/379 48/7206 4.68132295197e-06 ko00380 Tryptophan metabolism 12/379 50/7206 7.41262170283e-06 ko00643 Styrene degradation 4/379 4/7206 7.53780404271e-06 ko00983 Drug metabolism - other enzymes 10/379 42/7206 4.65326266737e-05 ko00982 Drug metabolism - cytochrome P450 9/379 37/7206 9.35504069612e-05 ko00362 Benzoate degradation 4/379 6/7206 0.000103851267964 ko05164 Influenza A 21/379 167/7206 0.000164451829732 ko00980 Metabolism of xenobiotics by cytochrome P450 9/379 40/7206 0.000178699858466 ko03320 PPAR signaling pathway 12/379 69/7206 0.000217334426804 ko00830 Retinol metabolism 9/379 42/7206 0.000265407299919 ko00040 Pentose and glucuronate interconversions 7/379 26/7206 0.000289953376951 ko00592 alpha-Linolenic acid metabolism 6/379 19/7206 0.000307419443294 ko04060 Cytokine-cytokine receptor interaction 22/379 191/7206 0.000439296291647 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/379 4/7206 0.000554990869998 ko04146 Peroxisome 13/379 89/7206 0.000703972331494 ko04610 Complement and coagulation cascades 12/379 79/7206 0.000785018830636 ko00330 Arginine and proline metabolism 10/379 61/7206 0.00116674167792 ko00950 Isoquinoline alkaloid biosynthesis 4/379 10/7206 0.00122767155317 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/379 5/7206 0.00133329855432 ko04064 NF-kappa B signaling pathway 13/379 96/7206 0.00144818536667 ko04080 Neuroactive ligand-receptor interaction 9/379 423/7206 0.00152942545476 ko04723 Retrograde endocannabinoid signaling 1/379 175/7206 0.0015862918784 ko04975 Fat digestion and absorption 7/379 35/7206 0.00196813441578 ko00071 Fatty acid degradation 8/379 45/7206 0.00211045734814 ko05034 Alcoholism 3/379 238/7206 0.00264924656011 ko00100 Steroid biosynthesis 5/379 21/7206 0.00396117374123 ko04390 Hippo signaling pathway 2/379 188/7206 0.00432230183954 ko04724 Glutamatergic synapse 1/379 152/7206 0.00489860965512 ko00053 Ascorbate and aldarate metabolism 5/379 22/7206 0.00490886673075 ko04668 TNF signaling pathway 14/379 120/7206 0.00545347241177 ko00051 Fructose and mannose metabolism 7/379 42/7206 0.00575484194612 ko03040 Spliceosome 1/379 145/7206 0.00717302764693 ko04110 Cell cycle 1/379 145/7206 0.00717302764693 ko00640 Propanoate metabolism 6/379 34/7206 0.00781167703777 ko05160 Hepatitis C 16/379 153/7206 0.00869736695344 ko00500 Starch and sucrose metabolism 6/379 35/7206 0.00902068585598 ko04621 NOD-like receptor signaling pathway 16/379 157/7206 0.0100604189253 ko04713 Circadian entrainment 1/379 136/7206 0.0102453207012 ko05162 Measles 13/379 120/7206 0.0115309941924 ko00260 Glycine, serine and threonine metabolism 7/379 48/7206 0.0119956835784 ko03013 RNA transport 2/379 166/7206 0.0124695841419 ko00920 Sulfur metabolism 3/379 10/7206 0.0131317915983 ko04540 Gap junction 1/379 128/7206 0.0147936437304 ko04622 RIG-I-like receptor signaling pathway 8/379 62/7206 0.0152482526169 ko04972 Pancreatic secretion 12/379 111/7206 0.0157436482768 ko05215 Prostate cancer 12/379 111/7206 0.0157436482768 ko04380 Osteoclast differentiation 14/379 134/7206 0.016276110392 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/379 11/7206 0.0173625846799 ko00590 Arachidonic acid metabolism 7/379 52/7206 0.0182278853777 ko04960 Aldosterone-regulated sodium reabsorption 6/379 41/7206 0.0191945225714 ko04973 Carbohydrate digestion and absorption 6/379 42/7206 0.0214344693422 ko00565 Ether lipid metabolism 6/379 42/7206 0.0214344693422 ko04710 Circadian rhythm 6/379 43/7206 0.0238447267022 ko00281 Geraniol degradation 2/379 5/7206 0.0248167200636 ko00591 Linoleic acid metabolism 4/379 22/7206 0.0259434391291 ko04310 Wnt signaling pathway 3/379 181/7206 0.0263044958473 ko00052 Galactose metabolism 5/379 33/7206 0.0275867105475 ko04152 AMPK signaling pathway 15/379 161/7206 0.0297175785898 ko05032 Morphine addiction 1/379 110/7206 0.0305432130649 ko00680 Methane metabolism 5/379 34/7206 0.0309961990833 ko00860 Porphyrin and chlorophyll metabolism 5/379 34/7206 0.0309961990833 ko04931 Insulin resistance 13/379 137/7206 0.0326657233675 ko04114 Oocyte meiosis 2/379 139/7206 0.0343609931225 ko00410 beta-Alanine metabolism 5/379 35/7206 0.0346587846214 ko04068 FoxO signaling pathway 15/379 167/7206 0.0352936204514 ko01212 Fatty acid metabolism 7/379 60/7206 0.0368835668056 ko05150 Staphylococcus aureus infection 5/379 36/7206 0.038578293695 ko05145 Toxoplasmosis 12/379 126/7206 0.0412451629371 ko04932 Non-alcoholic fatty liver disease (NAFLD) 16/379 182/7206 0.041321826379 ko04672 Intestinal immune network for IgA production 5/379 37/7206 0.0427577367385 ko04350 TGF-beta signaling pathway 1/379 103/7206 0.0440060722799 ko04213 Longevity regulating pathway - multiple species 9/379 86/7206 0.0453776683773 ko00561 Glycerolipid metabolism 7/379 63/7206 0.0462841230163 ko04144 Endocytosis 10/379 342/7206 0.046552712981 ko04657 IL-17 signaling pathway 9/379 87/7206 0.047258595408 ko05133 Pertussis 9/379 87/7206 0.047258595408 ko05142 Chagas disease (American trypanosomiasis) 12/379 130/7206 0.0472942198463 ko04662 B cell receptor signaling pathway 9/379 88/7206 0.049270558561