ko pathway ratio_in_study ratio_in_pop p_value ko04610 Complement and coagulation cascades 22/258 79/7206 2.00180371057e-14 ko04974 Protein digestion and absorption 23/258 96/7206 1.72841573845e-13 ko00350 Tyrosine metabolism 11/258 33/7206 9.64372301727e-09 ko04976 Bile secretion 16/258 80/7206 1.58343867115e-08 ko04975 Fat digestion and absorption 10/258 35/7206 2.42176434941e-07 ko04978 Mineral absorption 10/258 40/7206 9.54363235138e-07 ko00360 Phenylalanine metabolism 7/258 17/7206 9.94601314243e-07 ko00380 Tryptophan metabolism 11/258 50/7206 1.08289511803e-06 ko00140 Steroid hormone biosynthesis 10/258 41/7206 1.22287017172e-06 ko00983 Drug metabolism - other enzymes 10/258 42/7206 1.55498706675e-06 ko05204 Chemical carcinogenesis 10/258 48/7206 5.71673205412e-06 ko00260 Glycine, serine and threonine metabolism 10/258 48/7206 5.71673205412e-06 ko04977 Vitamin digestion and absorption 7/258 22/7206 7.47575466662e-06 ko04973 Carbohydrate digestion and absorption 9/258 42/7206 1.32953617451e-05 ko00830 Retinol metabolism 9/258 42/7206 1.32953617451e-05 ko04614 Renin-angiotensin system 6/258 18/7206 2.56705060052e-05 ko04972 Pancreatic secretion 14/258 111/7206 3.75126757458e-05 ko00980 Metabolism of xenobiotics by cytochrome P450 8/258 40/7206 6.88134255165e-05 ko00591 Linoleic acid metabolism 6/258 22/7206 9.14245614497e-05 ko05200 Pathways in cancer 4/258 492/7206 0.000125929786517 ko00340 Histidine metabolism 6/258 25/7206 0.0001982273755 ko00950 Isoquinoline alkaloid biosynthesis 4/258 10/7206 0.000284294742612 ko00982 Drug metabolism - cytochrome P450 7/258 37/7206 0.000284762064712 ko00120 Primary bile acid biosynthesis 5/258 20/7206 0.000563922627117 ko00053 Ascorbate and aldarate metabolism 5/258 22/7206 0.000903235482562 ko04010 MAPK signaling pathway 2/258 321/7206 0.00104390342066 ko05150 Staphylococcus aureus infection 6/258 36/7206 0.00156678261923 ko00590 Arachidonic acid metabolism 7/258 52/7206 0.00234265347015 ko04080 Neuroactive ligand-receptor interaction 5/258 423/7206 0.00410595947476 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/258 11/7206 0.00604579284544 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/258 4/7206 0.00730435225662 ko00643 Styrene degradation 2/258 4/7206 0.00730435225662 ko00965 Betalain biosynthesis 2/258 4/7206 0.00730435225662 ko05016 Huntington's disease 1/258 215/7206 0.00756015687625 ko05010 Alzheimer's disease 1/258 202/7206 0.0107486501029 ko00630 Glyoxylate and dicarboxylate metabolism 5/258 38/7206 0.0108053742221 ko03320 PPAR signaling pathway 7/258 69/7206 0.011304314582 ko00232 Caffeine metabolism 2/258 5/7206 0.0118872084473 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/258 5/7206 0.0118872084473 ko02010 ABC transporters 5/258 39/7206 0.0120415632402 ko00040 Pentose and glucuronate interconversions 4/258 26/7206 0.0128961015396 ko00480 Glutathione metabolism 6/258 55/7206 0.0132563825184 ko00565 Ether lipid metabolism 5/258 42/7206 0.0163173841421 ko05203 Viral carcinogenesis 3/258 277/7206 0.0193015410837 ko04015 Rap1 signaling pathway 3/258 278/7206 0.0194199875084 ko00720 Carbon fixation pathways in prokaryotes 3/258 17/7206 0.0212654270549 ko05161 Hepatitis B 1/258 173/7206 0.0217874636183 ko05224 Breast cancer 1/258 174/7206 0.0218063757001 ko04723 Retrograde endocannabinoid signaling 1/258 175/7206 0.02185336529 ko04217 Necroptosis 1/258 178/7206 0.0221628999497 ko04932 Non-alcoholic fatty liver disease (NAFLD) 1/258 182/7206 0.022970298562 ko00620 Pyruvate metabolism 5/258 46/7206 0.0234399438185 ko04151 PI3K-Akt signaling pathway 6/258 390/7206 0.0237896381494 ko04913 Ovarian steroidogenesis 6/258 63/7206 0.0245538614353 ko00561 Glycerolipid metabolism 6/258 63/7206 0.0245538614353 ko04144 Endocytosis 5/258 342/7206 0.0249979848372 ko03013 RNA transport 1/258 166/7206 0.0317734658521 ko00860 Porphyrin and chlorophyll metabolism 4/258 34/7206 0.0320446885158 ko04261 Adrenergic signaling in cardiomyocytes 2/258 205/7206 0.0351007229811 ko00901 Indole alkaloid biosynthesis 1/258 1/7206 0.0358034970858 ko00401 Novobiocin biosynthesis 1/258 1/7206 0.0358034970858 ko00100 Steroid biosynthesis 3/258 21/7206 0.0374616222687 ko04146 Peroxisome 7/258 89/7206 0.0397313271292 ko00520 Amino sugar and nucleotide sugar metabolism 5/258 55/7206 0.0460183447822 ko04722 Neurotrophin signaling pathway 1/258 160/7206 0.0476346418682 ko04725 Cholinergic synapse 1/258 160/7206 0.0476346418682