ko pathway ratio_in_study ratio_in_pop p_value ko00190 Oxidative phosphorylation 41/467 127/7206 7.37560923716e-19 ko05010 Alzheimer's disease 52/467 202/7206 9.87471771727e-19 ko01200 Carbon metabolism 41/467 128/7206 1.02164103969e-18 ko04260 Cardiac muscle contraction 33/467 98/7206 5.23822711657e-16 ko05012 Parkinson's disease 40/467 155/7206 1.14767062244e-14 ko00020 Citrate cycle (TCA cycle) 19/467 35/7206 2.84720644081e-14 ko05016 Huntington's disease 45/467 215/7206 8.62968802246e-13 ko05410 Hypertrophic cardiomyopathy (HCM) 29/467 100/7206 2.46057599238e-12 ko04261 Adrenergic signaling in cardiomyocytes 39/467 205/7206 6.33406717926e-10 ko00010 Glycolysis / Gluconeogenesis 22/467 74/7206 6.82577789818e-10 ko04932 Non-alcoholic fatty liver disease (NAFLD) 36/467 182/7206 9.7861952245e-10 ko00620 Pyruvate metabolism 17/467 46/7206 1.42596793094e-09 ko05414 Dilated cardiomyopathy 27/467 112/7206 1.43842138499e-09 ko00710 Carbon fixation in photosynthetic organisms 12/467 27/7206 3.39273137195e-08 ko04921 Oxytocin signaling pathway 35/467 209/7206 1.45848148553e-07 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 19/467 79/7206 4.24540884244e-07 ko04974 Protein digestion and absorption 21/467 96/7206 5.80481382489e-07 ko04022 cGMP-PKG signaling pathway 34/467 216/7206 1.402995024e-06 ko04510 Focal adhesion 36/467 240/7206 1.62369807684e-06 ko04922 Glucagon signaling pathway 24/467 128/7206 1.80460404838e-06 ko04020 Calcium signaling pathway 38/467 265/7206 2.70949550986e-06 ko01230 Biosynthesis of amino acids 18/467 85/7206 6.09673121695e-06 ko04512 ECM-receptor interaction 16/467 79/7206 3.594885184e-05 ko00640 Propanoate metabolism 10/467 34/7206 3.78222628697e-05 ko00071 Fatty acid degradation 11/467 45/7206 0.000101755540619 ko00630 Glyoxylate and dicarboxylate metabolism 10/467 38/7206 0.000107788432552 ko05034 Alcoholism 3/467 238/7206 0.000145397893594 ko00350 Tyrosine metabolism 9/467 33/7206 0.000177193428427 ko00680 Methane metabolism 9/467 34/7206 0.000227367048027 ko04723 Retrograde endocannabinoid signaling 25/467 175/7206 0.00023501102894 ko00362 Benzoate degradation 4/467 6/7206 0.000235254943136 ko04371 Apelin signaling pathway 25/467 177/7206 0.000252345792471 ko05200 Pathways in cancer 14/467 492/7206 0.000281695165161 ko00500 Starch and sucrose metabolism 9/467 35/7206 0.000288788779908 ko03013 RNA transport 1/467 166/7206 0.000324073161813 ko04060 Cytokine-cytokine receptor interaction 2/467 191/7206 0.000479030974118 ko00720 Carbon fixation pathways in prokaryotes 6/467 17/7206 0.000479883575162 ko04971 Gastric acid secretion 16/467 98/7206 0.00050373797234 ko04144 Endocytosis 8/467 342/7206 0.000638696660999 ko05416 Viral myocarditis 11/467 55/7206 0.00066529369501 ko05168 Herpes simplex infection 2/467 182/7206 0.000683353671573 ko05322 Systemic lupus erythematosus 1/467 151/7206 0.000687667294005 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/467 4/7206 0.00102993030876 ko00643 Styrene degradation 3/467 4/7206 0.00102993030876 ko04062 Chemokine signaling pathway 3/467 201/7206 0.00121909486694 ko04270 Vascular smooth muscle contraction 21/467 154/7206 0.00124003139777 ko01210 2-Oxocarboxylic acid metabolism 6/467 20/7206 0.00127191559191 ko05203 Viral carcinogenesis 6/467 277/7206 0.00162016204094 ko04550 Signaling pathways regulating pluripotency of stem cells 2/467 165/7206 0.00203731915932 ko04964 Proximal tubule bicarbonate reclamation 7/467 29/7206 0.00205073622438 ko05231 Choline metabolism in cancer 1/467 134/7206 0.00217078561528 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/467 5/7206 0.00245083511953 ko00250 Alanine, aspartate and glutamate metabolism 8/467 38/7206 0.00254419508706 ko00360 Phenylalanine metabolism 5/467 17/7206 0.00360664759599 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 4/467 11/7206 0.0039841924383 ko04142 Lysosome 2/467 151/7206 0.00415513557306 ko00830 Retinol metabolism 8/467 42/7206 0.00489013968871 ko04152 AMPK signaling pathway 20/467 161/7206 0.00501706148423 ko03040 Spliceosome 2/467 145/7206 0.0059245519432 ko00310 Lysine degradation 11/467 73/7206 0.0069039356851 ko00280 Valine, leucine and isoleucine degradation 9/467 54/7206 0.00726777904405 ko04014 Ras signaling pathway 8/467 279/7206 0.00886318499187 ko05164 Influenza A 3/467 167/7206 0.00975373375268 ko04390 Hippo signaling pathway 4/467 188/7206 0.00992760831879 ko04978 Mineral absorption 7/467 40/7206 0.013231008914 ko00380 Tryptophan metabolism 8/467 50/7206 0.0141454194381 ko04146 Peroxisome 12/467 89/7206 0.014266422449 ko01212 Fatty acid metabolism 9/467 60/7206 0.0143424532906 ko05166 HTLV-I infection 9/467 292/7206 0.0144668394152 ko04659 Th17 cell differentiation 1/467 106/7206 0.0147628633229 ko00030 Pentose phosphate pathway 6/467 32/7206 0.015359444992 ko00220 Arginine biosynthesis 5/467 24/7206 0.0170276290624 ko05161 Hepatitis B 4/467 173/7206 0.0184719891121 ko05224 Breast cancer 4/467 174/7206 0.0185109393577 ko04713 Circadian entrainment 16/467 136/7206 0.0200896734987 ko04658 Th1 and Th2 cell differentiation 1/467 96/7206 0.0205668623361 ko04650 Natural killer cell mediated cytotoxicity 1/467 97/7206 0.0206544457594 ko02020 Two-component system 4/467 17/7206 0.0210794350757 ko04620 Toll-like receptor signaling pathway 1/467 100/7206 0.0214606532715 ko00950 Isoquinoline alkaloid biosynthesis 3/467 10/7206 0.0230377053861 ko00040 Pentose and glucuronate interconversions 5/467 26/7206 0.0236972830922 ko05167 Kaposi's sarcoma-associated herpesvirus infection 5/467 191/7206 0.0244746255643 ko04925 Aldosterone synthesis and secretion 13/467 105/7206 0.0246460115104 ko04110 Cell cycle 3/467 145/7206 0.0252875280608 ko04614 Renin-angiotensin system 4/467 18/7206 0.0257501410586 ko00270 Cysteine and methionine metabolism 7/467 47/7206 0.0302924131556 ko04970 Salivary secretion 12/467 95/7206 0.0317927173209 ko04150 mTOR signaling pathway 5/467 184/7206 0.0327265151126 ko00281 Geraniol degradation 2/467 5/7206 0.036761357378 ko04976 Bile secretion 10/467 80/7206 0.0375402952034 ko02010 ABC transporters 6/467 39/7206 0.0378245265368 ko05220 Chronic myeloid leukemia 1/467 85/7206 0.0432723657176 ko04210 Apoptosis 5/467 180/7206 0.0442305893357 ko00140 Steroid hormone biosynthesis 6/467 41/7206 0.0468055092693 ko04621 NOD-like receptor signaling pathway 4/467 157/7206 0.0468372762018 ko05142 Chagas disease (American trypanosomiasis) 3/467 130/7206 0.0474731570573 ko04630 Jak-STAT signaling pathway 3/467 132/7206 0.0477547921759 ko05215 Prostate cancer 2/467 111/7206 0.0484117153248 ko04070 Phosphatidylinositol signaling system 2/467 112/7206 0.0491129169197