ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 44/629 80/7206 2.22074584142e-26 ko04724 Glutamatergic synapse 58/629 152/7206 7.09701930748e-24 ko04080 Neuroactive ligand-receptor interaction 100/629 423/7206 8.52008321381e-22 ko04728 Dopaminergic synapse 61/629 185/7206 3.28748786869e-21 ko05033 Nicotine addiction 32/629 56/7206 3.57843212898e-20 ko04713 Circadian entrainment 47/629 136/7206 1.72825500308e-17 ko05032 Morphine addiction 41/629 110/7206 9.63046427677e-17 ko04723 Retrograde endocannabinoid signaling 52/629 175/7206 4.96249262366e-16 ko04727 GABAergic synapse 40/629 110/7206 6.276792257e-16 ko04911 Insulin secretion 37/629 117/7206 1.17931582209e-12 ko05031 Amphetamine addiction 32/629 91/7206 1.59274896356e-12 ko04725 Cholinergic synapse 44/629 160/7206 1.9666961818e-12 ko04024 cAMP signaling pathway 60/629 279/7206 2.4506091354e-11 ko04726 Serotonergic synapse 37/629 137/7206 2.1160643021e-10 ko04966 Collecting duct acid secretion 15/629 26/7206 3.44712931253e-10 ko04744 Phototransduction 17/629 36/7206 1.42387883465e-09 ko04720 Long-term potentiation 28/629 99/7206 1.14928054687e-08 ko05030 Cocaine addiction 23/629 73/7206 2.54884485627e-08 ko04261 Adrenergic signaling in cardiomyocytes 43/629 205/7206 4.01933391463e-08 ko04921 Oxytocin signaling pathway 42/629 209/7206 2.61378312469e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 21/629 74/7206 7.44407788486e-07 ko05110 Vibrio cholerae infection 19/629 63/7206 9.00548529467e-07 ko04514 Cell adhesion molecules (CAMs) 28/629 130/7206 5.17025735699e-06 ko05164 Influenza A 1/629 167/7206 5.41449627056e-06 ko04020 Calcium signaling pathway 46/629 265/7206 6.0649360541e-06 ko04970 Salivary secretion 22/629 95/7206 1.59126775376e-05 ko05120 Epithelial cell signaling in Helicobacter pylori infection 21/629 92/7206 3.12013169707e-05 ko03040 Spliceosome 1/629 145/7206 3.95325991951e-05 ko04060 Cytokine-cytokine receptor interaction 3/629 191/7206 4.32446229355e-05 ko04925 Aldosterone synthesis and secretion 22/629 105/7206 8.1780737044e-05 ko04971 Gastric acid secretion 21/629 98/7206 8.39419385163e-05 ko04120 Ubiquitin mediated proteolysis 1/629 138/7206 9.02074709426e-05 ko04010 MAPK signaling pathway 48/629 321/7206 0.000163755560711 ko04145 Phagosome 29/629 162/7206 0.000179568201143 ko04972 Pancreatic secretion 22/629 111/7206 0.000229511829894 ko04745 Phototransduction - fly 11/629 38/7206 0.000276288037399 ko05203 Viral carcinogenesis 9/629 277/7206 0.000441813618928 ko04742 Taste transduction 14/629 61/7206 0.000607421020668 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/629 14/7206 0.000704096407556 ko04540 Gap junction 23/629 128/7206 0.000717647888689 ko05323 Rheumatoid arthritis 18/629 89/7206 0.000840584814746 ko04730 Long-term depression 16/629 78/7206 0.000953692504643 ko05034 Alcoholism 36/629 238/7206 0.000961257476768 ko04924 Renin secretion 17/629 86/7206 0.00140741511233 ko04510 Focal adhesion 8/629 240/7206 0.00149665952158 ko05168 Herpes simplex infection 5/629 182/7206 0.00194338436304 ko04621 NOD-like receptor signaling pathway 4/629 157/7206 0.0024911428112 ko04022 cGMP-PKG signaling pathway 32/629 216/7206 0.00297548499455 ko04626 Plant-pathogen interaction 6/629 18/7206 0.00321422570631 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 15/629 79/7206 0.00374422975038 ko05205 Proteoglycans in cancer 11/629 271/7206 0.00404355013951 ko04740 Olfactory transduction 15/629 80/7206 0.00409049796408 ko05322 Systemic lupus erythematosus 4/629 151/7206 0.00497980454315 ko03013 RNA transport 5/629 166/7206 0.00500505505523 ko04932 Non-alcoholic fatty liver disease (NAFLD) 6/629 182/7206 0.00500953273618 ko04141 Protein processing in endoplasmic reticulum 6/629 184/7206 0.00504173403195 ko04260 Cardiac muscle contraction 17/629 98/7206 0.00572857364024 ko04350 TGF-beta signaling pathway 2/629 103/7206 0.00782968432279 ko05161 Hepatitis B 6/629 173/7206 0.00917059421876 ko04964 Proximal tubule bicarbonate reclamation 7/629 29/7206 0.0106269030876 ko01524 Platinum drug resistance 1/629 76/7206 0.0132461639365 ko04612 Antigen processing and presentation 1/629 77/7206 0.0133395090848 ko04114 Oocyte meiosis 21/629 139/7206 0.0138330351469 ko03008 Ribosome biogenesis in eukaryotes 1/629 79/7206 0.0138722307952 ko05166 HTLV-I infection 14/629 292/7206 0.0143462799255 ko04961 Endocrine and other factor-regulated calcium reabsorption 11/629 59/7206 0.0164320858122 ko04611 Platelet activation 6/629 163/7206 0.0165421745185 ko04140 Autophagy - animal 6/629 164/7206 0.0165992749322 ko00190 Oxidative phosphorylation 19/629 127/7206 0.016954803697 ko05215 Prostate cancer 3/629 111/7206 0.0171224098628 ko04110 Cell cycle 5/629 145/7206 0.0171898961534 ko04630 Jak-STAT signaling pathway 4/629 132/7206 0.0180367332479 ko04146 Peroxisome 2/629 89/7206 0.0225141597117 ko05010 Alzheimer's disease 27/629 202/7206 0.022533787958 ko04750 Inflammatory mediator regulation of TRP channels 18/629 122/7206 0.0230747289091 ko05169 Epstein-Barr virus infection 9/629 206/7206 0.0233124502811 ko04211 Longevity regulating pathway 4/629 123/7206 0.0238603283278 ko04976 Bile secretion 13/629 80/7206 0.0258950194133 ko00603 Glycosphingolipid biosynthesis - globo and isoglobo series 3/629 8/7206 0.0265580952868 ko05016 Huntington's disease 10/629 215/7206 0.0272256110504 ko04072 Phospholipase D signaling pathway 26/629 197/7206 0.0292781550128 ko04014 Ras signaling pathway 35/629 279/7206 0.0296168364381 ko04962 Vasopressin-regulated water reabsorption 10/629 58/7206 0.0319197318369 ko04360 Axon guidance 30/629 233/7206 0.0325573156369 ko04668 TNF signaling pathway 4/629 120/7206 0.0326353438484 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 4/629 15/7206 0.0360610781947 ko00512 Mucin type O-glycan biosynthesis 6/629 29/7206 0.0361840053408 ko00561 Glycerolipid metabolism 1/629 63/7206 0.0410595458474 ko04640 Hematopoietic cell lineage 1/629 64/7206 0.0416324315041 ko05211 Renal cell carcinoma 3/629 96/7206 0.0453661847127 ko04064 NF-kappa B signaling pathway 3/629 96/7206 0.0453661847127 ko05146 Amoebiasis 3/629 99/7206 0.0460693668425