ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	197/1212	423/7206	1.97666092805e-49
ko04724	Glutamatergic synapse	91/1212	152/7206	1.16742589523e-33
ko05033	Nicotine addiction	48/1212	56/7206	1.11379523952e-29
ko05032	Morphine addiction	68/1212	110/7206	1.50380801106e-26
ko04727	GABAergic synapse	66/1212	110/7206	9.88009118146e-25
ko04713	Circadian entrainment	74/1212	136/7206	6.35201047984e-24
ko04721	Synaptic vesicle cycle	52/1212	80/7206	4.95523143046e-22
ko04725	Cholinergic synapse	77/1212	160/7206	1.64608687357e-20
ko04728	Dopaminergic synapse	83/1212	185/7206	1.3992593845e-19
ko04723	Retrograde endocannabinoid signaling	77/1212	175/7206	1.23277034e-17
ko04024	cAMP signaling pathway	105/1212	279/7206	2.2299260226e-17
ko04020	Calcium signaling pathway	100/1212	265/7206	7.7047023959e-17
ko04744	Phototransduction	27/1212	36/7206	1.94004965477e-14
ko04742	Taste transduction	36/1212	61/7206	9.91312186686e-14
ko04726	Serotonergic synapse	59/1212	137/7206	2.73669748133e-13
ko04921	Oxytocin signaling pathway	78/1212	209/7206	5.72913663922e-13
ko04911	Insulin secretion	52/1212	117/7206	1.64031767333e-12
ko04720	Long-term potentiation	45/1212	99/7206	2.06225040918e-11
ko05031	Amphetamine addiction	42/1212	91/7206	5.28803942033e-11
ko03040	Spliceosome	1/1212	145/7206	1.19606472245e-10
ko04261	Adrenergic signaling in cardiomyocytes	71/1212	205/7206	2.95636422282e-10
ko04970	Salivary secretion	40/1212	95/7206	4.39928524185e-09
ko04360	Axon guidance	74/1212	233/7206	1.14268834324e-08
ko05203	Viral carcinogenesis	17/1212	277/7206	1.0936882206e-07
ko05168	Herpes simplex infection	8/1212	182/7206	3.30447357165e-07
ko04966	Collecting duct acid secretion	16/1212	26/7206	3.67086489126e-07
ko04022	cGMP-PKG signaling pathway	66/1212	216/7206	4.07862218806e-07
ko05030	Cocaine addiction	30/1212	73/7206	7.13948872264e-07
ko04971	Gastric acid secretion	37/1212	98/7206	7.49778042869e-07
ko03013	RNA transport	7/1212	166/7206	8.53645480368e-07
ko04740	Olfactory transduction	32/1212	80/7206	9.99517565232e-07
ko04925	Aldosterone synthesis and secretion	38/1212	105/7206	1.24531349625e-06
ko04120	Ubiquitin mediated proteolysis	5/1212	138/7206	2.59803396234e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1212	74/7206	4.58012250841e-06
ko04060	Cytokine-cytokine receptor interaction	11/1212	191/7206	5.12183684641e-06
ko05322	Systemic lupus erythematosus	7/1212	151/7206	7.61074880676e-06
ko04621	NOD-like receptor signaling pathway	8/1212	157/7206	1.19279361064e-05
ko04514	Cell adhesion molecules (CAMs)	42/1212	130/7206	1.3632184943e-05
ko04540	Gap junction	41/1212	128/7206	2.08534298094e-05
ko04070	Phosphatidylinositol signaling system	37/1212	112/7206	3.06572334156e-05
ko04072	Phospholipase D signaling pathway	56/1212	197/7206	4.05099380728e-05
ko04064	NF-kappa B signaling pathway	3/1212	96/7206	4.7154325378e-05
ko04141	Protein processing in endoplasmic reticulum	12/1212	184/7206	5.28150180686e-05
ko04924	Renin secretion	30/1212	86/7206	5.55447920092e-05
ko04923	Regulation of lipolysis in adipocytes	27/1212	77/7206	8.75832281523e-05
ko04730	Long-term depression	27/1212	78/7206	0.000108048331231
ko04610	Complement and coagulation cascades	2/1212	79/7206	0.000110092369462
ko03008	Ribosome biogenesis in eukaryotes	2/1212	79/7206	0.000110092369462
ko05164	Influenza A	11/1212	167/7206	0.000137427418737
ko04972	Pancreatic secretion	35/1212	111/7206	0.000157462605819
ko04010	MAPK signaling pathway	80/1212	321/7206	0.000168235598465
ko04110	Cell cycle	9/1212	145/7206	0.000187444448634
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1212	79/7206	0.000191247258653
ko04745	Phototransduction - fly	16/1212	38/7206	0.000203524376563
ko04014	Ras signaling pathway	71/1212	279/7206	0.000216900448109
ko05140	Leishmaniasis	2/1212	75/7206	0.00025194828169
ko05414	Dilated cardiomyopathy	34/1212	112/7206	0.000315286044599
ko05169	Epstein-Barr virus infection	17/1212	206/7206	0.000434550926561
ko04976	Bile secretion	26/1212	80/7206	0.000471854846041
ko05110	Vibrio cholerae infection	22/1212	63/7206	0.000491345951634
ko04915	Estrogen signaling pathway	38/1212	131/7206	0.000530463886427
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1212	14/7206	0.000722171415424
ko04750	Inflammatory mediator regulation of TRP channels	35/1212	122/7206	0.000888177415106
ko04612	Antigen processing and presentation	3/1212	77/7206	0.00103360145159
ko04626	Plant-pathogen interaction	9/1212	18/7206	0.00119127045436
ko05161	Hepatitis B	14/1212	173/7206	0.00129916058485
ko04964	Proximal tubule bicarbonate reclamation	12/1212	29/7206	0.00152168369339
ko04260	Cardiac muscle contraction	29/1212	98/7206	0.00153470898331
ko05205	Proteoglycans in cancer	27/1212	271/7206	0.00157592484193
ko00240	Pyrimidine metabolism	7/1212	110/7206	0.00183123812418
ko04214	Apoptosis - fly	3/1212	72/7206	0.0021746347725
ko04146	Peroxisome	5/1212	89/7206	0.00247870540141
ko04371	Apelin signaling pathway	45/1212	177/7206	0.00304948509496
ko05321	Inflammatory bowel disease (IBD)	2/1212	56/7206	0.0037933571232
ko00562	Inositol phosphate metabolism	26/1212	89/7206	0.00381214519852
ko05144	Malaria	1/1212	45/7206	0.00432695633306
ko00071	Fatty acid degradation	1/1212	45/7206	0.00432695633306
ko03420	Nucleotide excision repair	1/1212	46/7206	0.00449571109135
ko05145	Toxoplasmosis	10/1212	126/7206	0.00540006396001
ko00480	Glutathione metabolism	2/1212	55/7206	0.00567574332408
ko00310	Lysine degradation	4/1212	73/7206	0.00676769750078
ko03022	Basal transcription factors	1/1212	44/7206	0.00696029866849
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1212	59/7206	0.00809197270394
ko00590	Arachidonic acid metabolism	2/1212	52/7206	0.00818627083743
ko04922	Glucagon signaling pathway	33/1212	128/7206	0.00856296617442
ko04930	Type II diabetes mellitus	17/1212	54/7206	0.00904268746186
ko00330	Arginine and proline metabolism	3/1212	61/7206	0.00908149912531
ko04657	IL-17 signaling pathway	6/1212	87/7206	0.00918869948282
ko05133	Pertussis	6/1212	87/7206	0.00918869948282
ko04622	RIG-I-like receptor signaling pathway	3/1212	62/7206	0.0093364254427
ko05162	Measles	10/1212	120/7206	0.0095105220534
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1212	40/7206	0.0097633363685
ko00140	Steroid hormone biosynthesis	1/1212	41/7206	0.0100971192117
ko00630	Glyoxylate and dicarboxylate metabolism	1/1212	38/7206	0.0147980151302
ko04062	Chemokine signaling pathway	47/1212	201/7206	0.0163470626433
ko05131	Shigellosis	6/1212	82/7206	0.0171300988915
ko03018	RNA degradation	6/1212	84/7206	0.0176698759705
ko04115	p53 signaling pathway	5/1212	74/7206	0.0181043732038
ko05231	Choline metabolism in cancer	33/1212	134/7206	0.019250126285
ko04213	Longevity regulating pathway - multiple species	23/1212	86/7206	0.019335127117
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1212	100/7206	0.0209967265364
ko04973	Carbohydrate digestion and absorption	13/1212	42/7206	0.0212281294377
ko00500	Starch and sucrose metabolism	1/1212	35/7206	0.0218833204184
ko05166	HTLV-I infection	35/1212	292/7206	0.0250117565012
ko04330	Notch signaling pathway	4/1212	62/7206	0.0257598199679
ko04668	TNF signaling pathway	11/1212	120/7206	0.0257900690206
ko04658	Th1 and Th2 cell differentiation	8/1212	96/7206	0.0267982718475
ko04912	GnRH signaling pathway	30/1212	122/7206	0.0272214735926
ko04510	Focal adhesion	28/1212	240/7206	0.0282144311798
ko00910	Nitrogen metabolism	7/1212	19/7206	0.0292116871999
ko04015	Rap1 signaling pathway	60/1212	278/7206	0.0334582464276
ko03320	PPAR signaling pathway	5/1212	69/7206	0.0340468030243
ko00983	Drug metabolism - other enzymes	2/1212	42/7206	0.0364515527289
ko04152	AMPK signaling pathway	37/1212	161/7206	0.0422226420219
ko04217	Necroptosis	20/1212	178/7206	0.0424941690667
ko04210	Apoptosis	20/1212	180/7206	0.0428384494017
ko01524	Platinum drug resistance	6/1212	76/7206	0.043192198462
ko00512	Mucin type O-glycan biosynthesis	9/1212	29/7206	0.0478913012203
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1212	92/7206	0.0479339186884
ko05340	Primary immunodeficiency	1/1212	30/7206	0.0486357700018
ko05214	Glioma	20/1212	79/7206	0.0489066375327