ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	87/479	423/7206	7.20395945095e-23
ko05033	Nicotine addiction	29/479	56/7206	4.3657225498e-20
ko04724	Glutamatergic synapse	42/479	152/7206	4.13971540677e-16
ko04727	GABAergic synapse	30/479	110/7206	1.12161204186e-11
ko04728	Dopaminergic synapse	38/479	185/7206	2.16386815087e-10
ko05032	Morphine addiction	28/479	110/7206	3.26550001377e-10
ko04723	Retrograde endocannabinoid signaling	36/479	175/7206	6.31934120898e-10
ko04721	Synaptic vesicle cycle	23/479	80/7206	9.62180088554e-10
ko04713	Circadian entrainment	29/479	136/7206	1.31872333257e-08
ko05030	Cocaine addiction	19/479	73/7206	1.64492989109e-07
ko04978	Mineral absorption	13/479	40/7206	9.61020340629e-07
ko04725	Cholinergic synapse	28/479	160/7206	1.7820875479e-06
ko04976	Bile secretion	18/479	80/7206	3.49085202451e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	17/479	74/7206	4.8239282678e-06
ko04726	Serotonergic synapse	24/479	137/7206	9.64098629642e-06
ko05031	Amphetamine addiction	18/479	91/7206	2.34020742999e-05
ko04911	Insulin secretion	21/479	117/7206	2.37481034131e-05
ko04742	Taste transduction	14/479	61/7206	3.36475989561e-05
ko04744	Phototransduction	10/479	36/7206	8.08063302556e-05
ko04024	cAMP signaling pathway	36/479	279/7206	0.000110295039754
ko05205	Proteoglycans in cancer	5/479	271/7206	0.000410857728093
ko05166	HTLV-I infection	6/479	292/7206	0.00043323901721
ko04964	Proximal tubule bicarbonate reclamation	8/479	29/7206	0.00044401676996
ko04150	mTOR signaling pathway	2/479	184/7206	0.000469974132106
ko04924	Renin secretion	15/479	86/7206	0.000474019548895
ko04621	NOD-like receptor signaling pathway	1/479	157/7206	0.000482214495738
ko04974	Protein digestion and absorption	16/479	96/7206	0.000525866299793
ko04730	Long-term depression	14/479	78/7206	0.00053842438401
ko04217	Necroptosis	2/479	178/7206	0.000678371467155
ko05322	Systemic lupus erythematosus	1/479	151/7206	0.000707791714709
ko05203	Viral carcinogenesis	6/479	277/7206	0.00082138391842
ko03040	Spliceosome	1/479	145/7206	0.00103777070757
ko04970	Salivary secretion	15/479	95/7206	0.00138221147351
ko04261	Adrenergic signaling in cardiomyocytes	26/479	205/7206	0.00144519375857
ko04120	Ubiquitin mediated proteolysis	1/479	138/7206	0.00149435308707
ko04140	Autophagy - animal	2/479	164/7206	0.00210732124369
ko04630	Jak-STAT signaling pathway	1/479	132/7206	0.00218669950012
ko05169	Epstein-Barr virus infection	4/479	206/7206	0.00268583742512
ko04211	Longevity regulating pathway	1/479	123/7206	0.00314201077141
ko04514	Cell adhesion molecules (CAMs)	18/479	130/7206	0.0035150113933
ko05168	Herpes simplex infection	3/479	182/7206	0.00357629684191
ko05161	Hepatitis B	3/479	173/7206	0.00483432678219
ko04614	Renin-angiotensin system	5/479	18/7206	0.00527541880895
ko00830	Retinol metabolism	8/479	42/7206	0.00569632057543
ko03013	RNA transport	3/479	166/7206	0.00673523942725
ko04933	AGE-RAGE signaling pathway in diabetic complications	2/479	135/7206	0.00838552357165
ko01521	EGFR tyrosine kinase inhibitor resistance	1/479	106/7206	0.00973053397055
ko04010	MAPK signaling pathway	33/479	321/7206	0.0112219226255
ko00770	Pantothenate and CoA biosynthesis	4/479	14/7206	0.0112973992381
ko05206	MicroRNAs in cancer	4/479	177/7206	0.01356245794
ko04218	Cellular senescence	4/479	177/7206	0.01356245794
ko05146	Amoebiasis	1/479	99/7206	0.014119320113
ko04914	Progesterone-mediated oocyte maturation	1/479	104/7206	0.0148920873965
ko04066	HIF-1 signaling pathway	2/479	123/7206	0.016845505483
ko05145	Toxoplasmosis	2/479	126/7206	0.0171964632
ko04110	Cell cycle	3/479	145/7206	0.0181140537946
ko04142	Lysosome	3/479	151/7206	0.0189241891903
ko04972	Pancreatic secretion	14/479	111/7206	0.0189541285779
ko04720	Long-term potentiation	13/479	99/7206	0.022100781669
ko00290	Valine, leucine and isoleucine biosynthesis	2/479	4/7206	0.0241816964867
ko04141	Protein processing in endoplasmic reticulum	5/479	184/7206	0.0243221441597
ko04919	Thyroid hormone signaling pathway	3/479	143/7206	0.0255462829784
ko04068	FoxO signaling pathway	4/479	167/7206	0.0258742796412
ko04146	Peroxisome	1/479	89/7206	0.0298728300699
ko05222	Small cell lung cancer	1/479	89/7206	0.0298728300699
ko04921	Oxytocin signaling pathway	22/479	209/7206	0.0328581662089
ko04932	Non-alcoholic fatty liver disease (NAFLD)	5/479	182/7206	0.0331182803604
ko05215	Prostate cancer	2/479	111/7206	0.0334651176331
ko00910	Nitrogen metabolism	4/479	19/7206	0.0336246417852
ko04510	Focal adhesion	8/479	240/7206	0.0342249118136
ko04260	Cardiac muscle contraction	12/479	98/7206	0.0375414697407
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	10/479	79/7206	0.0397403020838
ko04950	Maturity onset diabetes of the young	5/479	29/7206	0.0400979310053
ko03018	RNA degradation	1/479	84/7206	0.0436370940688
ko01200	Carbon metabolism	3/479	128/7206	0.0474553361055
ko05200	Pathways in cancer	22/479	492/7206	0.0483143862767
ko04012	ErbB signaling pathway	2/479	109/7206	0.04880720854
ko05016	Huntington's disease	7/479	215/7206	0.049749346967