ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 89/851 145/7206 4.99875614805e-47 ko03030 DNA replication 30/851 38/7206 1.7797354936e-21 ko03013 RNA transport 67/851 166/7206 1.92952167544e-21 ko03050 Proteasome 36/851 54/7206 2.41163501295e-21 ko04080 Neuroactive ligand-receptor interaction 3/851 423/7206 8.75090679142e-20 ko03008 Ribosome biogenesis in eukaryotes 38/851 79/7206 1.10813618027e-15 ko04111 Cell cycle - yeast 38/851 90/7206 2.09945904272e-13 ko04110 Cell cycle 50/851 145/7206 4.37925622986e-13 ko03430 Mismatch repair 17/851 22/7206 2.16275469996e-12 ko03015 mRNA surveillance pathway 37/851 93/7206 3.87425659309e-12 ko03420 Nucleotide excision repair 24/851 46/7206 2.43762661046e-11 ko04020 Calcium signaling pathway 3/851 265/7206 3.83090340961e-11 ko03410 Base excision repair 21/851 38/7206 1.04495816696e-10 ko00240 Pyrimidine metabolism 38/851 110/7206 2.82646728783e-10 ko05010 Alzheimer's disease 1/851 202/7206 2.96444201106e-10 ko05169 Epstein-Barr virus infection 56/851 206/7206 8.80603295334e-10 ko04113 Meiosis - yeast 26/851 70/7206 3.47356440076e-08 ko03440 Homologous recombination 19/851 41/7206 3.73935819562e-08 ko04144 Endocytosis 12/851 342/7206 4.1730009412e-08 ko04724 Glutamatergic synapse 1/851 152/7206 1.53372503319e-07 ko04921 Oxytocin signaling pathway 4/851 209/7206 1.65138380484e-07 ko05217 Basal cell carcinoma 24/851 68/7206 3.56198242965e-07 ko03460 Fanconi anemia pathway 20/851 51/7206 4.80344032729e-07 ko04060 Cytokine-cytokine receptor interaction 4/851 191/7206 1.09240238335e-06 ko04723 Retrograde endocannabinoid signaling 3/851 175/7206 1.14414209351e-06 ko03020 RNA polymerase 14/851 29/7206 1.29765555257e-06 ko04725 Cholinergic synapse 3/851 160/7206 5.17093639774e-06 ko04022 cGMP-PKG signaling pathway 7/851 216/7206 8.68786971787e-06 ko04726 Serotonergic synapse 2/851 137/7206 1.121322305e-05 ko05012 Parkinson's disease 3/851 155/7206 1.17171346063e-05 ko04932 Non-alcoholic fatty liver disease (NAFLD) 5/851 182/7206 1.2899718561e-05 ko00230 Purine metabolism 44/851 194/7206 1.36389340271e-05 ko03018 RNA degradation 24/851 84/7206 2.36404046284e-05 ko04727 GABAergic synapse 1/851 110/7206 3.32444664938e-05 ko05032 Morphine addiction 1/851 110/7206 3.32444664938e-05 ko04024 cAMP signaling pathway 13/851 279/7206 4.07103818044e-05 ko04330 Notch signaling pathway 19/851 62/7206 5.78262643077e-05 ko04713 Circadian entrainment 3/851 136/7206 7.29377574718e-05 ko04650 Natural killer cell mediated cytotoxicity 1/851 97/7206 0.000103473664331 ko04971 Gastric acid secretion 1/851 98/7206 0.000104055021355 ko04915 Estrogen signaling pathway 3/851 131/7206 0.000105209536843 ko04922 Glucagon signaling pathway 3/851 128/7206 0.00015201337383 ko04970 Salivary secretion 1/851 95/7206 0.000156692253895 ko04070 Phosphatidylinositol signaling system 2/851 112/7206 0.000164788896296 ko04925 Aldosterone synthesis and secretion 2/851 105/7206 0.000353075906953 ko04920 Adipocytokine signaling pathway 1/851 89/7206 0.000357815671083 ko04911 Insulin secretion 3/851 117/7206 0.000457987455489 ko04062 Chemokine signaling pathway 9/851 201/7206 0.000509502925437 ko04924 Renin secretion 1/851 86/7206 0.000542392802326 ko04621 NOD-like receptor signaling pathway 6/851 157/7206 0.000648145615933 ko04310 Wnt signaling pathway 37/851 181/7206 0.000655069330372 ko04260 Cardiac muscle contraction 2/851 98/7206 0.00075224153599 ko04540 Gap junction 4/851 128/7206 0.000772370652705 ko04270 Vascular smooth muscle contraction 6/851 154/7206 0.000903323859015 ko04730 Long-term depression 1/851 78/7206 0.00114905006962 ko04931 Insulin resistance 5/851 137/7206 0.0011879237053 ko04610 Complement and coagulation cascades 1/851 79/7206 0.00118851338008 ko04371 Apelin signaling pathway 8/851 177/7206 0.00128701953436 ko04912 GnRH signaling pathway 4/851 122/7206 0.00157162007889 ko04072 Phospholipase D signaling pathway 10/851 197/7206 0.00160802760147 ko05231 Choline metabolism in cancer 5/851 134/7206 0.00166468928187 ko05030 Cocaine addiction 1/851 73/7206 0.00168265979605 ko04933 AGE-RAGE signaling pathway in diabetic complications 5/851 135/7206 0.00169244059093 ko04261 Adrenergic signaling in cardiomyocytes 11/851 205/7206 0.00203729557073 ko05166 HTLV-I infection 52/851 292/7206 0.00213022208972 ko04662 B cell receptor signaling pathway 2/851 88/7206 0.00232775683061 ko04530 Tight junction 13/851 228/7206 0.00234809943953 ko04630 Jak-STAT signaling pathway 5/851 132/7206 0.00238682154229 ko00562 Inositol phosphate metabolism 2/851 89/7206 0.00238911235494 ko04390 Hippo signaling pathway 36/851 188/7206 0.00277611464382 ko04010 MAPK signaling pathway 22/851 321/7206 0.00342889727258 ko03060 Protein export 8/851 23/7206 0.00352606040469 ko04974 Protein digestion and absorption 3/851 96/7206 0.00391357201787 ko04720 Long-term potentiation 3/851 99/7206 0.00407786379319 ko05414 Dilated cardiomyopathy 4/851 112/7206 0.00442257062902 ko04138 Autophagy - yeast 2/851 81/7206 0.00487051019282 ko04712 Circadian rhythm - plant 4/851 7/7206 0.00503664643217 ko00561 Glycerolipid metabolism 1/851 63/7206 0.00545943612328 ko00600 Sphingolipid metabolism 1/851 63/7206 0.00545943612328 ko04910 Insulin signaling pathway 9/851 172/7206 0.00550512740432 ko04659 Th17 cell differentiation 4/851 106/7206 0.00594324601871 ko04380 Osteoclast differentiation 6/851 134/7206 0.00625499977748 ko04217 Necroptosis 10/851 178/7206 0.00665256069855 ko04923 Regulation of lipolysis in adipocytes 2/851 77/7206 0.0069755754559 ko04068 FoxO signaling pathway 9/851 167/7206 0.00717540138097 ko04146 Peroxisome 3/851 89/7206 0.00784327313745 ko05031 Amphetamine addiction 3/851 91/7206 0.00797428310055 ko04961 Endocrine and other factor-regulated calcium reabsorption 1/851 59/7206 0.00808397132703 ko05120 Epithelial cell signaling in Helicobacter pylori infection 3/851 92/7206 0.00818071335259 ko04611 Platelet activation 9/851 163/7206 0.00947029099334 ko04728 Dopaminergic synapse 11/851 185/7206 0.0106095950305 ko04972 Pancreatic secretion 5/851 111/7206 0.0114688649672 ko00564 Glycerophospholipid metabolism 4/851 99/7206 0.0114865074485 ko05410 Hypertrophic cardiomyopathy (HCM) 4/851 100/7206 0.0115943957461 ko04550 Signaling pathways regulating pluripotency of stem cells 30/851 165/7206 0.0142395615206 ko04810 Regulation of actin cytoskeleton 19/851 264/7206 0.0150856935335 ko03022 Basal transcription factors 11/851 44/7206 0.0152804943401 ko04120 Ubiquitin mediated proteolysis 26/851 138/7206 0.0155728678507 ko04950 Maturity onset diabetes of the young 8/851 29/7206 0.0162709425822 ko05224 Breast cancer 31/851 174/7206 0.0170353879592 ko04930 Type II diabetes mellitus 1/851 54/7206 0.0177675448467 ko04510 Focal adhesion 17/851 240/7206 0.0190069428694 ko05142 Chagas disease (American trypanosomiasis) 7/851 130/7206 0.0190750605005 ko04514 Cell adhesion molecules (CAMs) 7/851 130/7206 0.0190750605005 ko05152 Tuberculosis 12/851 187/7206 0.0208796768818 ko04142 Lysosome 9/851 151/7206 0.0213733603158 ko04340 Hedgehog signaling pathway 13/851 58/7206 0.0216744284707 ko04976 Bile secretion 3/851 80/7206 0.0219834216174 ko05161 Hepatitis B 11/851 173/7206 0.0228868458992 ko04152 AMPK signaling pathway 10/851 161/7206 0.0254011332051 ko04071 Sphingolipid signaling pathway 10/851 162/7206 0.0256576991659 ko04620 Toll-like receptor signaling pathway 5/851 100/7206 0.028785459206 ko04622 RIG-I-like receptor signaling pathway 2/851 62/7206 0.0292571940375 ko05110 Vibrio cholerae infection 2/851 63/7206 0.0293879391214 ko04913 Ovarian steroidogenesis 2/851 63/7206 0.0293879391214 ko04640 Hematopoietic cell lineage 2/851 64/7206 0.0298641899197 ko05167 Kaposi's sarcoma-associated herpesvirus infection 13/851 191/7206 0.0301297157003 ko05140 Leishmaniasis 3/851 75/7206 0.0303331864632 ko04750 Inflammatory mediator regulation of TRP channels 7/851 122/7206 0.0333724604808 ko04666 Fc gamma R-mediated phagocytosis 7/851 122/7206 0.0333724604808 ko04066 HIF-1 signaling pathway 7/851 123/7206 0.0335143886073 ko05168 Herpes simplex infection 31/851 182/7206 0.0353125703794 ko04151 PI3K-Akt signaling pathway 33/851 390/7206 0.0356683918719 ko04014 Ras signaling pathway 22/851 279/7206 0.0372251706527 ko05146 Amoebiasis 5/851 99/7206 0.0395546264995 ko04213 Longevity regulating pathway - multiple species 4/851 86/7206 0.0415873773736 ko05016 Huntington's disease 16/851 215/7206 0.0415999716997 ko05160 Hepatitis C 10/851 153/7206 0.0419625704901 ko05133 Pertussis 4/851 87/7206 0.0423990171996 ko04668 TNF signaling pathway 7/851 120/7206 0.0443439295399