ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	154/1137	423/7206	6.70378586314e-27
ko04724	Glutamatergic synapse	73/1137	152/7206	4.19694303545e-21
ko05033	Nicotine addiction	40/1137	56/7206	1.45770795547e-20
ko05032	Morphine addiction	54/1137	110/7206	1.94723787398e-16
ko04713	Circadian entrainment	61/1137	136/7206	5.0462539597e-16
ko04727	GABAergic synapse	53/1137	110/7206	1.03188622479e-15
ko04725	Cholinergic synapse	64/1137	160/7206	7.62847194796e-14
ko04020	Calcium signaling pathway	86/1137	265/7206	6.23645283156e-12
ko04728	Dopaminergic synapse	65/1137	185/7206	5.45637604454e-11
ko04723	Retrograde endocannabinoid signaling	62/1137	175/7206	1.26595602692e-10
ko04721	Synaptic vesicle cycle	36/1137	80/7206	4.93751513619e-10
ko04744	Phototransduction	22/1137	36/7206	7.69731422638e-10
ko04911	Insulin secretion	45/1137	117/7206	1.84131462568e-09
ko03013	RNA transport	3/1137	166/7206	3.76480079069e-09
ko04726	Serotonergic synapse	49/1137	137/7206	7.44343276053e-09
ko03040	Spliceosome	2/1137	145/7206	1.06276020552e-08
ko03010	Ribosome	1/1137	129/7206	1.13061301895e-08
ko04024	cAMP signaling pathway	80/1137	279/7206	3.16593949495e-08
ko04972	Pancreatic secretion	40/1137	111/7206	1.25965882636e-07
ko04970	Salivary secretion	36/1137	95/7206	1.94254880164e-07
ko05322	Systemic lupus erythematosus	4/1137	151/7206	2.09869779378e-07
ko04742	Taste transduction	26/1137	61/7206	4.82940088026e-07
ko04921	Oxytocin signaling pathway	61/1137	209/7206	6.26857717353e-07
ko05203	Viral carcinogenesis	17/1137	277/7206	1.23735237217e-06
ko05031	Amphetamine addiction	33/1137	91/7206	1.45519017437e-06
ko04022	cGMP-PKG signaling pathway	61/1137	216/7206	2.46117384192e-06
ko04974	Protein digestion and absorption	34/1137	96/7206	2.88010185624e-06
ko04971	Gastric acid secretion	34/1137	98/7206	3.74942802489e-06
ko04110	Cell cycle	6/1137	145/7206	1.50443858875e-05
ko05030	Cocaine addiction	26/1137	73/7206	2.82510667321e-05
ko04120	Ubiquitin mediated proteolysis	6/1137	138/7206	4.51499635136e-05
ko04740	Olfactory transduction	27/1137	80/7206	6.85507658345e-05
ko04924	Renin secretion	28/1137	86/7206	0.000131628620378
ko05169	Epstein-Barr virus infection	14/1137	206/7206	0.00013460296034
ko04710	Circadian rhythm	17/1137	43/7206	0.000145292551224
ko05164	Influenza A	10/1137	167/7206	0.000147746673637
ko04976	Bile secretion	26/1137	80/7206	0.000162246323167
ko04964	Proximal tubule bicarbonate reclamation	13/1137	29/7206	0.000199194112083
ko04070	Phosphatidylinositol signaling system	33/1137	112/7206	0.000209574410961
ko04925	Aldosterone synthesis and secretion	31/1137	105/7206	0.000356874844154
ko04745	Phototransduction - fly	15/1137	38/7206	0.000362159012521
ko00643	Styrene degradation	4/1137	4/7206	0.000617067040917
ko04720	Long-term potentiation	29/1137	99/7206	0.00069034427692
ko04514	Cell adhesion molecules (CAMs)	35/1137	130/7206	0.000950758800844
ko04072	Phospholipase D signaling pathway	49/1137	197/7206	0.000975423586151
ko04261	Adrenergic signaling in cardiomyocytes	50/1137	205/7206	0.00123362318753
ko04621	NOD-like receptor signaling pathway	11/1137	157/7206	0.00123888731629
ko00520	Amino sugar and nucleotide sugar metabolism	1/1137	55/7206	0.00133992364947
ko05168	Herpes simplex infection	14/1137	182/7206	0.00135516736543
ko04141	Protein processing in endoplasmic reticulum	14/1137	184/7206	0.00137031440726
ko05162	Measles	7/1137	120/7206	0.00141057013505
ko05161	Hepatitis B	13/1137	173/7206	0.00145793319508
ko02010	ABC transporters	14/1137	39/7206	0.00169334229675
ko04711	Circadian rhythm - fly	7/1137	13/7206	0.00170538577831
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1137	59/7206	0.00171940750087
ko04730	Long-term depression	23/1137	78/7206	0.00248088129231
ko04630	Jak-STAT signaling pathway	9/1137	132/7206	0.00248996486661
ko04750	Inflammatory mediator regulation of TRP channels	32/1137	122/7206	0.00250405625315
ko05016	Huntington's disease	19/1137	215/7206	0.00316298390749
ko04270	Vascular smooth muscle contraction	38/1137	154/7206	0.00352375436622
ko05205	Proteoglycans in cancer	26/1137	271/7206	0.00372654512447
ko03015	mRNA surveillance pathway	5/1137	93/7206	0.00372657723773
ko04966	Collecting duct acid secretion	10/1137	26/7206	0.00432918997776
ko05219	Bladder cancer	1/1137	48/7206	0.00456630590088
ko04217	Necroptosis	15/1137	178/7206	0.004769070177
ko04620	Toll-like receptor signaling pathway	6/1137	100/7206	0.00519399665418
ko05014	Amyotrophic lateral sclerosis (ALS)	21/1137	74/7206	0.00566704656008
ko05166	HTLV-I infection	30/1137	292/7206	0.00679496765082
ko03420	Nucleotide excision repair	1/1137	46/7206	0.00696868479933
ko04064	NF-kappa B signaling pathway	6/1137	96/7206	0.00700802650418
ko05130	Pathogenic Escherichia coli infection	4/1137	77/7206	0.00701588436216
ko04014	Ras signaling pathway	61/1137	279/7206	0.00712229097072
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1137	182/7206	0.00717430826375
ko05416	Viral myocarditis	2/1137	55/7206	0.00852177952943
ko04960	Aldosterone-regulated sodium reabsorption	13/1137	41/7206	0.00907707409232
ko05140	Leishmaniasis	4/1137	75/7206	0.00994693842042
ko05220	Chronic myeloid leukemia	5/1137	85/7206	0.0100420335024
ko03022	Basal transcription factors	1/1137	44/7206	0.0107364915802
ko04111	Cell cycle - yeast	6/1137	90/7206	0.0130893151121
ko04622	RIG-I-like receptor signaling pathway	3/1137	62/7206	0.0134658762423
ko05131	Shigellosis	5/1137	82/7206	0.0137676464013
ko04214	Apoptosis - fly	4/1137	72/7206	0.0138455703072
ko04614	Renin-angiotensin system	7/1137	18/7206	0.0153680009601
ko00830	Retinol metabolism	13/1137	42/7206	0.0166612243103
ko05133	Pertussis	6/1137	87/7206	0.0178003392874
ko04113	Meiosis - yeast	4/1137	70/7206	0.0195790873972
ko04360	Axon guidance	50/1137	233/7206	0.021887757497
ko05211	Renal cell carcinoma	7/1137	96/7206	0.0228860445045
ko03410	Base excision repair	1/1137	38/7206	0.0230517957613
ko04612	Antigen processing and presentation	5/1137	77/7206	0.0261672766847
ko04664	Fc epsilon RI signaling pathway	5/1137	77/7206	0.0261672766847
ko04371	Apelin signaling pathway	39/1137	177/7206	0.0276843105813
ko04010	MAPK signaling pathway	65/1137	321/7206	0.0281384970824
ko00120	Primary bile acid biosynthesis	7/1137	20/7206	0.0281443277866
ko04512	ECM-receptor interaction	20/1137	79/7206	0.0282755804734
ko00350	Tyrosine metabolism	10/1137	33/7206	0.030079562649
ko05212	Pancreatic cancer	6/1137	83/7206	0.0326804666146
ko00860	Porphyrin and chlorophyll metabolism	1/1137	34/7206	0.0336667921212
ko04660	T cell receptor signaling pathway	11/1137	124/7206	0.0339121070171
ko05150	Staphylococcus aureus infection	1/1137	36/7206	0.0351512732631
ko05100	Bacterial invasion of epithelial cells	8/1137	99/7206	0.0361906929648
ko04540	Gap junction	29/1137	128/7206	0.0370981009496
ko00280	Valine, leucine and isoleucine degradation	3/1137	54/7206	0.0379549476887
ko04978	Mineral absorption	11/1137	40/7206	0.049782027106