ko pathway ratio_in_study ratio_in_pop p_value ko03030 DNA replication 17/396 38/7206 2.69426523782e-12 ko04110 Cell cycle 31/396 145/7206 3.28410841316e-11 ko05217 Basal cell carcinoma 19/396 68/7206 2.07750301053e-09 ko04111 Cell cycle - yeast 21/396 90/7206 1.03889928911e-08 ko04080 Neuroactive ligand-receptor interaction 3/396 423/7206 1.20648553584e-07 ko03040 Spliceosome 24/396 145/7206 9.70347612235e-07 ko03410 Base excision repair 11/396 38/7206 3.75939199807e-06 ko03050 Proteasome 13/396 54/7206 4.81924839548e-06 ko04020 Calcium signaling pathway 1/396 265/7206 6.66465893416e-06 ko00240 Pyrimidine metabolism 19/396 110/7206 7.02298267353e-06 ko04950 Maturity onset diabetes of the young 9/396 29/7206 1.56290934058e-05 ko03008 Ribosome biogenesis in eukaryotes 15/396 79/7206 2.04233830901e-05 ko04144 Endocytosis 4/396 342/7206 4.50606800215e-05 ko04550 Signaling pathways regulating pluripotency of stem cells 22/396 165/7206 9.11051999497e-05 ko04113 Meiosis - yeast 13/396 70/7206 9.23971483344e-05 ko04921 Oxytocin signaling pathway 1/396 209/7206 0.000154387491754 ko00230 Purine metabolism 24/396 194/7206 0.000160846241592 ko04062 Chemokine signaling pathway 1/396 201/7206 0.000226173500735 ko04340 Hedgehog signaling pathway 11/396 58/7206 0.000262977491784 ko03460 Fanconi anemia pathway 10/396 51/7206 0.000376332156316 ko04932 Non-alcoholic fatty liver disease (NAFLD) 1/396 182/7206 0.00073538943737 ko05205 Proteoglycans in cancer 28/396 271/7206 0.00101711287484 ko04371 Apelin signaling pathway 1/396 177/7206 0.00112287056865 ko04725 Cholinergic synapse 1/396 160/7206 0.00229118287303 ko04024 cAMP signaling pathway 5/396 279/7206 0.00291600155297 ko04270 Vascular smooth muscle contraction 1/396 154/7206 0.00340466390389 ko04022 cGMP-PKG signaling pathway 3/396 216/7206 0.00353811608201 ko05166 HTLV-I infection 28/396 292/7206 0.00358739119581 ko05224 Breast cancer 19/396 174/7206 0.00365310388043 ko05200 Pathways in cancer 42/396 492/7206 0.00387894830591 ko03020 RNA polymerase 6/396 29/7206 0.00427935314335 ko04390 Hippo signaling pathway 20/396 188/7206 0.00489821845715 ko05202 Transcriptional misregulation in cancer 20/396 188/7206 0.00489821845715 ko03013 RNA transport 18/396 166/7206 0.00508824749672 ko03430 Mismatch repair 5/396 22/7206 0.00591433539271 ko04723 Retrograde endocannabinoid signaling 2/396 175/7206 0.00624796687278 ko04713 Circadian entrainment 1/396 136/7206 0.00694181708269 ko04726 Serotonergic synapse 1/396 137/7206 0.00698679928943 ko05169 Epstein-Barr virus infection 21/396 206/7206 0.00732903033838 ko04612 Antigen processing and presentation 10/396 77/7206 0.00906420487561 ko04630 Jak-STAT signaling pathway 1/396 132/7206 0.0104176774894 ko04310 Wnt signaling pathway 18/396 181/7206 0.0125438133512 ko04728 Dopaminergic synapse 3/396 185/7206 0.013416469923 ko00670 One carbon pool by folate 4/396 20/7206 0.0215848105734 ko03440 Homologous recombination 6/396 41/7206 0.023296302215 ko04072 Phospholipase D signaling pathway 4/396 197/7206 0.0256199962648 ko05222 Small cell lung cancer 10/396 89/7206 0.0298559906078 ko04060 Cytokine-cytokine receptor interaction 4/396 191/7206 0.0348884952496 ko04071 Sphingolipid signaling pathway 3/396 162/7206 0.0352855696712 ko04611 Platelet activation 3/396 163/7206 0.0353987748805 ko03015 mRNA surveillance pathway 10/396 93/7206 0.0358752233795 ko03420 Nucleotide excision repair 6/396 46/7206 0.0386393947782 ko04975 Fat digestion and absorption 5/396 35/7206 0.0407334388228 ko04971 Gastric acid secretion 1/396 98/7206 0.0437777339887 ko05100 Bacterial invasion of epithelial cells 1/396 99/7206 0.0438628384329 ko04218 Cellular senescence 16/396 177/7206 0.0439540341147 ko05168 Herpes simplex infection 4/396 182/7206 0.0468223835269 ko04141 Protein processing in endoplasmic reticulum 4/396 184/7206 0.047202024207 ko04922 Glucagon signaling pathway 2/396 128/7206 0.0481387871244 ko03010 Ribosome 2/396 129/7206 0.0484314697213 ko05142 Chagas disease (American trypanosomiasis) 2/396 130/7206 0.0488260260049 ko04621 NOD-like receptor signaling pathway 3/396 157/7206 0.0489156512501 ko04915 Estrogen signaling pathway 2/396 131/7206 0.0493221420477