ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	29/440	56/7206	3.997476386e-21
ko04080	Neuroactive ligand-receptor interaction	76/440	423/7206	1.3687395449e-18
ko04724	Glutamatergic synapse	41/440	152/7206	1.16796344466e-16
ko04721	Synaptic vesicle cycle	25/440	80/7206	3.57752782076e-12
ko04727	GABAergic synapse	28/440	110/7206	4.4417484803e-11
ko04728	Dopaminergic synapse	37/440	185/7206	7.30040351894e-11
ko05032	Morphine addiction	25/440	110/7206	6.41382188743e-09
ko04713	Circadian entrainment	28/440	136/7206	8.28160270804e-09
ko05014	Amyotrophic lateral sclerosis (ALS)	20/440	74/7206	9.1995469564e-09
ko04723	Retrograde endocannabinoid signaling	32/440	175/7206	1.50000070701e-08
ko04360	Axon guidance	38/440	233/7206	1.73613032303e-08
ko04024	cAMP signaling pathway	42/440	279/7206	4.93998618282e-08
ko04911	Insulin secretion	24/440	117/7206	1.06400007764e-07
ko04514	Cell adhesion molecules (CAMs)	25/440	130/7206	2.16248579263e-07
ko05030	Cocaine addiction	18/440	73/7206	2.37213278869e-07
ko04725	Cholinergic synapse	26/440	160/7206	3.61627053477e-06
ko05031	Amphetamine addiction	18/440	91/7206	7.30776559171e-06
ko04742	Taste transduction	13/440	61/7206	6.06861669406e-05
ko04726	Serotonergic synapse	21/440	137/7206	7.6217571501e-05
ko04974	Protein digestion and absorption	16/440	96/7206	0.000202186242242
ko04964	Proximal tubule bicarbonate reclamation	8/440	29/7206	0.00024879493827
ko04010	MAPK signaling pathway	36/440	321/7206	0.000308598395212
ko04961	Endocrine and other factor-regulated calcium reabsorption	11/440	59/7206	0.000752725047347
ko04512	ECM-receptor interaction	13/440	79/7206	0.000891821943987
ko04972	Pancreatic secretion	16/440	111/7206	0.00106932323205
ko05322	Systemic lupus erythematosus	1/440	151/7206	0.0015455035637
ko04261	Adrenergic signaling in cardiomyocytes	24/440	205/7206	0.00173353690548
ko04218	Cellular senescence	2/440	177/7206	0.00209889380798
ko05164	Influenza A	2/440	167/7206	0.00294349757098
ko05203	Viral carcinogenesis	6/440	277/7206	0.00294802945854
ko04976	Bile secretion	12/440	80/7206	0.00313101602168
ko03013	RNA transport	2/440	166/7206	0.00444795803476
ko04211	Longevity regulating pathway	1/440	123/7206	0.00684334960944
ko05168	Herpes simplex infection	3/440	182/7206	0.00689750784214
ko04970	Salivary secretion	13/440	95/7206	0.007264061321
ko04730	Long-term depression	11/440	78/7206	0.00736805637042
ko00604	Glycosphingolipid biosynthesis - ganglio series	4/440	14/7206	0.00840143729533
ko04720	Long-term potentiation	13/440	99/7206	0.00876042304377
ko05205	Proteoglycans in cancer	7/440	271/7206	0.00940678582469
ko05162	Measles	1/440	120/7206	0.0104803785201
ko04068	FoxO signaling pathway	3/440	167/7206	0.0132658670282
ko05016	Huntington's disease	5/440	215/7206	0.013542692167
ko04060	Cytokine-cytokine receptor interaction	4/440	191/7206	0.0136386278814
ko04120	Ubiquitin mediated proteolysis	2/440	138/7206	0.0176141412509
ko04260	Cardiac muscle contraction	12/440	98/7206	0.017697219978
ko04611	Platelet activation	3/440	163/7206	0.0188121593029
ko04140	Autophagy - animal	3/440	164/7206	0.0190523529127
ko04151	PI3K-Akt signaling pathway	35/440	390/7206	0.0216374174876
ko01200	Carbon metabolism	2/440	128/7206	0.0241212230049
ko04217	Necroptosis	4/440	178/7206	0.0254035431224
ko04621	NOD-like receptor signaling pathway	3/440	157/7206	0.0262333684862
ko00564	Glycerophospholipid metabolism	1/440	99/7206	0.0310084060078
ko04978	Mineral absorption	6/440	40/7206	0.0328627859651
ko00230	Purine metabolism	5/440	194/7206	0.0328694968036
ko04540	Gap junction	14/440	128/7206	0.0369412435198
ko00430	Taurine and hypotaurine metabolism	3/440	14/7206	0.0497424120216