ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 101/625 423/7206 1.38430199375e-22 ko04724 Glutamatergic synapse 51/625 152/7206 2.25287274516e-18 ko05033 Nicotine addiction 29/625 56/7206 6.79302096886e-17 ko04728 Dopaminergic synapse 50/625 185/7206 9.26944497357e-14 ko04727 GABAergic synapse 37/625 110/7206 1.11533161011e-13 ko04713 Circadian entrainment 38/625 136/7206 3.26473256865e-11 ko04723 Retrograde endocannabinoid signaling 41/625 175/7206 2.03760160556e-09 ko04742 Taste transduction 21/625 61/7206 1.5901716909e-08 ko04725 Cholinergic synapse 37/625 160/7206 1.85254869933e-08 ko05032 Morphine addiction 29/625 110/7206 3.09307389369e-08 ko04721 Synaptic vesicle cycle 24/625 80/7206 3.26456955309e-08 ko04740 Olfactory transduction 24/625 80/7206 3.26456955309e-08 ko04744 Phototransduction 15/625 36/7206 9.93872208158e-08 ko05030 Cocaine addiction 22/625 73/7206 1.12058349014e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 22/625 74/7206 1.46708773426e-07 ko04911 Insulin secretion 28/625 117/7206 4.84689439153e-07 ko04024 cAMP signaling pathway 50/625 279/7206 5.86450217925e-07 ko04726 Serotonergic synapse 30/625 137/7206 1.44860302632e-06 ko04261 Adrenergic signaling in cardiomyocytes 39/625 205/7206 1.93622608601e-06 ko05031 Amphetamine addiction 22/625 91/7206 6.85891358843e-06 ko05164 Influenza A 1/625 167/7206 8.62231342152e-06 ko04060 Cytokine-cytokine receptor interaction 2/625 191/7206 1.01505684998e-05 ko04260 Cardiac muscle contraction 22/625 98/7206 2.42524357994e-05 ko03040 Spliceosome 1/625 145/7206 3.96883033376e-05 ko04140 Autophagy - animal 2/625 164/7206 6.51996138849e-05 ko04150 mTOR signaling pathway 3/625 184/7206 9.05397571462e-05 ko04514 Cell adhesion molecules (CAMs) 25/625 130/7206 0.000115212370908 ko05168 Herpes simplex infection 3/625 182/7206 0.000136781324803 ko04974 Protein digestion and absorption 20/625 96/7206 0.000169845202795 ko04976 Bile secretion 17/625 80/7206 0.000402860667738 ko05166 HTLV-I infection 10/625 292/7206 0.000423236342225 ko05162 Measles 1/625 120/7206 0.000427642031477 ko05203 Viral carcinogenesis 9/625 277/7206 0.000432523221387 ko04932 Non-alcoholic fatty liver disease (NAFLD) 4/625 182/7206 0.000457419844082 ko04970 Salivary secretion 19/625 95/7206 0.000595509038164 ko04621 NOD-like receptor signaling pathway 3/625 157/7206 0.00079540469997 ko05161 Hepatitis B 4/625 173/7206 0.000908279699763 ko04978 Mineral absorption 10/625 40/7206 0.00173048704008 ko03013 RNA transport 4/625 166/7206 0.00183354312961 ko00564 Glycerophospholipid metabolism 1/625 99/7206 0.00197040133884 ko04720 Long-term potentiation 18/625 99/7206 0.00313960969205 ko04120 Ubiquitin mediated proteolysis 3/625 138/7206 0.00321813322025 ko04730 Long-term depression 15/625 78/7206 0.00332181309304 ko04512 ECM-receptor interaction 15/625 79/7206 0.0035978599778 ko05169 Epstein-Barr virus infection 7/625 206/7206 0.00365301867956 ko05205 Proteoglycans in cancer 11/625 271/7206 0.00400021430726 ko04010 MAPK signaling pathway 43/625 321/7206 0.00422186114318 ko05322 Systemic lupus erythematosus 4/625 151/7206 0.00491352300882 ko05215 Prostate cancer 2/625 111/7206 0.00563056993877 ko04914 Progesterone-mediated oocyte maturation 2/625 104/7206 0.00784912431989 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 14/625 79/7206 0.00809879859818 ko04211 Longevity regulating pathway 3/625 123/7206 0.00887397091503 ko04137 Mitophagy - animal 1/625 82/7206 0.00913824097947 ko04924 Renin secretion 15/625 86/7206 0.0101668869853 ko04964 Proximal tubule bicarbonate reclamation 7/625 29/7206 0.0102749405912 ko04950 Maturity onset diabetes of the young 7/625 29/7206 0.0102749405912 ko05152 Tuberculosis 7/625 187/7206 0.0118342167998 ko03008 Ribosome biogenesis in eukaryotes 1/625 79/7206 0.0137200922951 ko04141 Protein processing in endoplasmic reticulum 7/625 184/7206 0.0159645489519 ko04611 Platelet activation 6/625 163/7206 0.0165753965024 ko04068 FoxO signaling pathway 6/625 167/7206 0.0169189232967 ko04540 Gap junction 19/625 128/7206 0.0171427457667 ko04921 Oxytocin signaling pathway 28/625 209/7206 0.0176594971232 ko04630 Jak-STAT signaling pathway 4/625 132/7206 0.01783001464 ko00350 Tyrosine metabolism 7/625 33/7206 0.0207997339799 ko04218 Cellular senescence 7/625 177/7206 0.0208179851876 ko04217 Necroptosis 7/625 178/7206 0.0209342194173 ko04146 Peroxisome 2/625 89/7206 0.0225496747692 ko04110 Cell cycle 5/625 145/7206 0.0238098449912 ko00430 Taurine and hypotaurine metabolism 4/625 14/7206 0.0277615791726 ko05410 Hypertrophic cardiomyopathy (HCM) 15/625 100/7206 0.0308497302229 ko04151 PI3K-Akt signaling pathway 46/625 390/7206 0.0327137736623 ko04020 Calcium signaling pathway 33/625 265/7206 0.0337346205289 ko01521 EGFR tyrosine kinase inhibitor resistance 3/625 106/7206 0.0343035539444 ko05034 Alcoholism 30/625 238/7206 0.0344419228868 ko05016 Huntington's disease 10/625 215/7206 0.0353620102663 ko04142 Lysosome 6/625 151/7206 0.0393005542661 ko04622 RIG-I-like receptor signaling pathway 1/625 62/7206 0.0408265156184 ko05414 Dilated cardiomyopathy 16/625 112/7206 0.0412359598701 ko00250 Alanine, aspartate and glutamate metabolism 7/625 38/7206 0.0422750799671 ko05206 MicroRNAs in cancer 8/625 177/7206 0.0427737020116 ko04138 Autophagy - yeast 2/625 81/7206 0.0451007388075