ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 76/766 152/7206 5.68719091815e-35 ko05033 Nicotine addiction 40/766 56/7206 3.58488455355e-27 ko04080 Neuroactive ligand-receptor interaction 122/766 423/7206 4.28193274851e-27 ko04728 Dopaminergic synapse 72/766 185/7206 1.15890997834e-24 ko04727 GABAergic synapse 53/766 110/7206 1.2477875726e-23 ko04713 Circadian entrainment 57/766 136/7206 1.41849569175e-21 ko05032 Morphine addiction 50/766 110/7206 6.17214107092e-21 ko04721 Synaptic vesicle cycle 42/766 80/7206 8.71267301678e-21 ko04723 Retrograde endocannabinoid signaling 64/766 175/7206 2.55503366396e-20 ko04024 cAMP signaling pathway 74/766 279/7206 3.22919635269e-14 ko04725 Cholinergic synapse 51/766 160/7206 1.2775867207e-13 ko04911 Insulin secretion 42/766 117/7206 2.14536409985e-13 ko04726 Serotonergic synapse 45/766 137/7206 1.12404969528e-12 ko05031 Amphetamine addiction 35/766 91/7206 2.2169097685e-12 ko04720 Long-term potentiation 36/766 99/7206 7.48792875799e-12 ko04020 Calcium signaling pathway 64/766 265/7206 1.46146772905e-10 ko04744 Phototransduction 19/766 36/7206 3.842063383e-10 ko04261 Adrenergic signaling in cardiomyocytes 53/766 205/7206 4.08383014947e-10 ko04921 Oxytocin signaling pathway 53/766 209/7206 7.70234123916e-10 ko04742 Taste transduction 24/766 61/7206 3.91744501581e-09 ko05030 Cocaine addiction 25/766 73/7206 5.01007518471e-08 ko04970 Salivary secretion 29/766 95/7206 7.88925901967e-08 ko04925 Aldosterone synthesis and secretion 29/766 105/7206 8.39980271809e-07 ko04010 MAPK signaling pathway 63/766 321/7206 1.01259956363e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 23/766 74/7206 1.23133857991e-06 ko03040 Spliceosome 1/766 145/7206 2.0321567688e-06 ko04514 Cell adhesion molecules (CAMs) 32/766 130/7206 4.03646859473e-06 ko04966 Collecting duct acid secretion 12/766 26/7206 4.50091081736e-06 ko05203 Viral carcinogenesis 9/766 277/7206 5.90942003088e-06 ko04060 Cytokine-cytokine receptor interaction 4/766 191/7206 1.20858528988e-05 ko05164 Influenza A 3/766 167/7206 1.82494829275e-05 ko04730 Long-term depression 21/766 78/7206 4.15382379039e-05 ko04022 cGMP-PKG signaling pathway 42/766 216/7206 0.000109490686809 ko05168 Herpes simplex infection 5/766 182/7206 0.000122312819081 ko04972 Pancreatic secretion 26/766 111/7206 0.000123211948906 ko04070 Phosphatidylinositol signaling system 26/766 112/7206 0.000130986826168 ko04072 Phospholipase D signaling pathway 39/766 197/7206 0.000138609247814 ko04971 Gastric acid secretion 23/766 98/7206 0.000198095545736 ko05110 Vibrio cholerae infection 17/766 63/7206 0.000214359180032 ko04740 Olfactory transduction 20/766 80/7206 0.000310417455298 ko04014 Ras signaling pathway 49/766 279/7206 0.000328699743269 ko04745 Phototransduction - fly 12/766 38/7206 0.000377792506601 ko03013 RNA transport 5/766 166/7206 0.000476747877047 ko05169 Epstein-Barr virus infection 8/766 206/7206 0.000530832589814 ko04110 Cell cycle 4/766 145/7206 0.000581273284261 ko04924 Renin secretion 20/766 86/7206 0.000597139696922 ko04260 Cardiac muscle contraction 22/766 98/7206 0.000683762023337 ko04621 NOD-like receptor signaling pathway 5/766 157/7206 0.000913865999029 ko04120 Ubiquitin mediated proteolysis 4/766 138/7206 0.00116303406201 ko05322 Systemic lupus erythematosus 5/766 151/7206 0.00126393049347 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 18/766 79/7206 0.0014245931657 ko05162 Measles 3/766 120/7206 0.0014492719885 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/766 14/7206 0.00200498485058 ko04360 Axon guidance 40/766 233/7206 0.00226795948671 ko04612 Antigen processing and presentation 1/766 77/7206 0.0026474615894 ko03008 Ribosome biogenesis in eukaryotes 1/766 79/7206 0.00268392893606 ko04141 Protein processing in endoplasmic reticulum 8/766 184/7206 0.00333652157604 ko04915 Estrogen signaling pathway 25/766 131/7206 0.00368478288346 ko04961 Endocrine and other factor-regulated calcium reabsorption 14/766 59/7206 0.00418769952228 ko05034 Alcoholism 39/766 238/7206 0.00524578439825 ko05120 Epithelial cell signaling in Helicobacter pylori infection 19/766 92/7206 0.00542418070405 ko05010 Alzheimer's disease 34/766 202/7206 0.00723279579121 ko05161 Hepatitis B 8/766 173/7206 0.0081207312618 ko04626 Plant-pathogen interaction 6/766 18/7206 0.00855012700143 ko00512 Mucin type O-glycan biosynthesis 8/766 29/7206 0.00884625709027 ko00513 Various types of N-glycan biosynthesis 10/766 42/7206 0.0108572114357 ko04750 Inflammatory mediator regulation of TRP channels 22/766 122/7206 0.0113279547492 ko04064 NF-kappa B signaling pathway 3/766 96/7206 0.0115657734928 ko00240 Pyrimidine metabolism 4/766 110/7206 0.0119756854468 ko04930 Type II diabetes mellitus 12/766 54/7206 0.0120313479914 ko05215 Prostate cancer 4/766 111/7206 0.0120766089557 ko04640 Hematopoietic cell lineage 1/766 64/7206 0.0126603846547 ko04540 Gap junction 23/766 128/7206 0.0127574611799 ko04510 Focal adhesion 14/766 240/7206 0.0137259797107 ko04140 Autophagy - animal 8/766 164/7206 0.0140984203845 ko00562 Inositol phosphate metabolism 17/766 89/7206 0.0144165130389 ko05205 Proteoglycans in cancer 17/766 271/7206 0.0156113455033 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 5/766 15/7206 0.0162196338242 ko04371 Apelin signaling pathway 29/766 177/7206 0.0181007060176 ko05414 Dilated cardiomyopathy 20/766 112/7206 0.0191763643374 ko04071 Sphingolipid signaling pathway 27/766 162/7206 0.019233015567 ko00310 Lysine degradation 2/766 73/7206 0.0212885470067 ko05140 Leishmaniasis 2/766 75/7206 0.0217400849825 ko04146 Peroxisome 3/766 89/7206 0.022830907667 ko00480 Glutathione metabolism 1/766 55/7206 0.0266550547949 ko04964 Proximal tubule bicarbonate reclamation 7/766 29/7206 0.0289031943125 ko03018 RNA degradation 3/766 84/7206 0.0314105343333 ko05323 Rheumatoid arthritis 16/766 89/7206 0.035387894574 ko04973 Carbohydrate digestion and absorption 9/766 42/7206 0.0384030236582 ko04932 Non-alcoholic fatty liver disease (NAFLD) 11/766 182/7206 0.0385425886664 ko04922 Glucagon signaling pathway 21/766 128/7206 0.0414604869917 ko04630 Jak-STAT signaling pathway 7/766 132/7206 0.0451649003641 ko04062 Chemokine signaling pathway 30/766 201/7206 0.0486686785601 ko04217 Necroptosis 11/766 178/7206 0.048945585766