ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	197/1213	423/7206	2.27160834479e-49
ko04724	Glutamatergic synapse	88/1213	152/7206	5.42041795337e-31
ko05033	Nicotine addiction	46/1213	56/7206	7.71807727821e-27
ko04713	Circadian entrainment	77/1213	136/7206	2.40365429898e-26
ko05032	Morphine addiction	66/1213	110/7206	1.03734497886e-24
ko04727	GABAergic synapse	63/1213	110/7206	4.13317416047e-22
ko04020	Calcium signaling pathway	108/1213	265/7206	4.14523184837e-21
ko04728	Dopaminergic synapse	85/1213	185/7206	7.72751836954e-21
ko04725	Cholinergic synapse	76/1213	160/7206	8.31625053154e-20
ko04721	Synaptic vesicle cycle	49/1213	80/7206	3.48690410135e-19
ko04921	Oxytocin signaling pathway	87/1213	209/7206	6.90778004907e-18
ko04723	Retrograde endocannabinoid signaling	76/1213	175/7206	5.26327206842e-17
ko04911	Insulin secretion	58/1213	117/7206	1.8148648866e-16
ko04726	Serotonergic synapse	62/1213	137/7206	4.10866179212e-15
ko04742	Taste transduction	37/1213	61/7206	1.34229368713e-14
ko04024	cAMP signaling pathway	99/1213	279/7206	1.96511475304e-14
ko04261	Adrenergic signaling in cardiomyocytes	75/1213	205/7206	4.3126037822e-12
ko05031	Amphetamine addiction	43/1213	91/7206	1.20503945539e-11
ko04970	Salivary secretion	44/1213	95/7206	1.62383417031e-11
ko04720	Long-term potentiation	45/1213	99/7206	2.12304228961e-11
ko03010	Ribosome	1/1213	129/7206	1.54597992813e-09
ko03040	Spliceosome	2/1213	145/7206	1.5536769465e-09
ko04022	cGMP-PKG signaling pathway	72/1213	216/7206	1.66707417295e-09
ko04744	Phototransduction	22/1213	36/7206	2.74033861922e-09
ko04925	Aldosterone synthesis and secretion	43/1213	105/7206	3.32709606897e-09
ko04360	Axon guidance	74/1213	233/7206	1.16987988207e-08
ko04740	Olfactory transduction	35/1213	80/7206	1.26392797661e-08
ko04971	Gastric acid secretion	39/1213	98/7206	5.84561561465e-08
ko05322	Systemic lupus erythematosus	5/1213	151/7206	2.51813297914e-07
ko04730	Long-term depression	32/1213	78/7206	3.26048052946e-07
ko05168	Herpes simplex infection	8/1213	182/7206	3.30049399357e-07
ko04010	MAPK signaling pathway	89/1213	321/7206	5.50946107439e-07
ko03013	RNA transport	7/1213	166/7206	8.55391500828e-07
ko05203	Viral carcinogenesis	19/1213	277/7206	1.02936335392e-06
ko05030	Cocaine addiction	29/1213	73/7206	3.87528513658e-06
ko04060	Cytokine-cytokine receptor interaction	11/1213	191/7206	5.10812036713e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	30/1213	79/7206	5.56309231072e-06
ko04540	Gap junction	42/1213	128/7206	7.2905467286e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1213	74/7206	1.25141625852e-05
ko04924	Renin secretion	31/1213	86/7206	1.46682687602e-05
ko04514	Cell adhesion molecules (CAMs)	41/1213	130/7206	2.76721837476e-05
ko04070	Phosphatidylinositol signaling system	37/1213	112/7206	3.08224290016e-05
ko04072	Phospholipase D signaling pathway	56/1213	197/7206	4.08488827812e-05
ko04120	Ubiquitin mediated proteolysis	7/1213	138/7206	4.45683912031e-05
ko04621	NOD-like receptor signaling pathway	9/1213	157/7206	5.1489620149e-05
ko04745	Phototransduction - fly	17/1213	38/7206	5.16560993357e-05
ko04260	Cardiac muscle contraction	33/1213	98/7206	5.28990480446e-05
ko04141	Protein processing in endoplasmic reticulum	12/1213	184/7206	5.3021012731e-05
ko04371	Apelin signaling pathway	51/1213	177/7206	5.94972004349e-05
ko04110	Cell cycle	8/1213	145/7206	6.81851377206e-05
ko04750	Inflammatory mediator regulation of TRP channels	38/1213	122/7206	7.6388573053e-05
ko04966	Collecting duct acid secretion	13/1213	26/7206	9.75346092419e-05
ko04610	Complement and coagulation cascades	2/1213	79/7206	0.000110065429352
ko03008	Ribosome biogenesis in eukaryotes	2/1213	79/7206	0.000110065429352
ko04014	Ras signaling pathway	72/1213	279/7206	0.000112525434864
ko05164	Influenza A	11/1213	167/7206	0.000137799763346
ko04972	Pancreatic secretion	35/1213	111/7206	0.000158105841946
ko05414	Dilated cardiomyopathy	34/1213	112/7206	0.000318640731968
ko05169	Epstein-Barr virus infection	17/1213	206/7206	0.000434424757765
ko05110	Vibrio cholerae infection	22/1213	63/7206	0.00049465486125
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1213	59/7206	0.000612488341647
ko04976	Bile secretion	26/1213	80/7206	0.000731719803528
ko04064	NF-kappa B signaling pathway	5/1213	96/7206	0.000878489540668
ko05140	Leishmaniasis	3/1213	75/7206	0.00100392202599
ko04612	Antigen processing and presentation	3/1213	77/7206	0.00103561790101
ko05410	Hypertrophic cardiomyopathy (HCM)	30/1213	100/7206	0.00104395223294
ko04930	Type II diabetes mellitus	19/1213	54/7206	0.0013819647147
ko04964	Proximal tubule bicarbonate reclamation	12/1213	29/7206	0.00153302163351
ko04915	Estrogen signaling pathway	36/1213	131/7206	0.0019939040574
ko04922	Glucagon signaling pathway	35/1213	128/7206	0.00263152541831
ko04710	Circadian rhythm	15/1213	43/7206	0.00350754100617
ko04657	IL-17 signaling pathway	5/1213	87/7206	0.00351061066203
ko05321	Inflammatory bowel disease (IBD)	2/1213	56/7206	0.00378885154647
ko05162	Measles	9/1213	120/7206	0.00432356426429
ko05144	Malaria	1/1213	45/7206	0.00432689855046
ko00071	Fatty acid degradation	1/1213	45/7206	0.00432689855046
ko03022	Basal transcription factors	1/1213	44/7206	0.00432845611418
ko04270	Vascular smooth muscle contraction	40/1213	154/7206	0.00433392314637
ko04916	Melanogenesis	37/1213	142/7206	0.00450069625179
ko03420	Nucleotide excision repair	1/1213	46/7206	0.00450236522753
ko05161	Hepatitis B	16/1213	173/7206	0.00531686624374
ko00280	Valine, leucine and isoleucine degradation	2/1213	54/7206	0.00555513807516
ko04626	Plant-pathogen interaction	8/1213	18/7206	0.00562256412639
ko00310	Lysine degradation	4/1213	73/7206	0.00677322936342
ko05205	Proteoglycans in cancer	30/1213	271/7206	0.00804677218232
ko00590	Arachidonic acid metabolism	2/1213	52/7206	0.00818859818588
ko05133	Pertussis	6/1213	87/7206	0.00918084987647
ko04330	Notch signaling pathway	3/1213	62/7206	0.0093500667966
ko04622	RIG-I-like receptor signaling pathway	3/1213	62/7206	0.0093500667966
ko04146	Peroxisome	6/1213	89/7206	0.00945138560642
ko05145	Toxoplasmosis	11/1213	126/7206	0.0114417463881
ko04630	Jak-STAT signaling pathway	12/1213	132/7206	0.0135348456715
ko00240	Pyrimidine metabolism	9/1213	110/7206	0.0139330169964
ko04912	GnRH signaling pathway	31/1213	122/7206	0.0142954869813
ko04217	Necroptosis	18/1213	178/7206	0.014511954053
ko05230	Central carbon metabolism in cancer	22/1213	81/7206	0.0165943106113
ko05131	Shigellosis	6/1213	82/7206	0.0171216440396
ko04015	Rap1 signaling pathway	62/1213	278/7206	0.0174205722456
ko00260	Glycine, serine and threonine metabolism	2/1213	48/7206	0.0180070380604
ko04115	p53 signaling pathway	5/1213	74/7206	0.0181124564853
ko00480	Glutathione metabolism	3/1213	55/7206	0.0183698287411
ko04960	Aldosterone-regulated sodium reabsorption	13/1213	41/7206	0.0187950067769
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1213	14/7206	0.0198819241027
ko04210	Apoptosis	19/1213	180/7206	0.0202612374675
ko04923	Regulation of lipolysis in adipocytes	21/1213	77/7206	0.0204597609268
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1213	182/7206	0.0204615326757
ko04973	Carbohydrate digestion and absorption	13/1213	42/7206	0.0213153977144
ko00680	Methane metabolism	11/1213	34/7206	0.0215919582674
ko04658	Th1 and Th2 cell differentiation	8/1213	96/7206	0.0268279087375
ko05215	Prostate cancer	10/1213	111/7206	0.0287069965222
ko00562	Inositol phosphate metabolism	23/1213	89/7206	0.0311926512294
ko04620	Toll-like receptor signaling pathway	9/1213	100/7206	0.0314918122147
ko00860	Porphyrin and chlorophyll metabolism	1/1213	34/7206	0.0345198387429
ko00380	Tryptophan metabolism	3/1213	50/7206	0.0367078255158
ko00330	Arginine and proline metabolism	4/1213	61/7206	0.0369081558721
ko05166	HTLV-I infection	36/1213	292/7206	0.0375731770074
ko03018	RNA degradation	7/1213	84/7206	0.0387646860906
ko04918	Thyroid hormone synthesis	22/1213	86/7206	0.0407856710787
ko01524	Platinum drug resistance	6/1213	76/7206	0.0432430830738
ko05214	Glioma	20/1213	79/7206	0.0490700537141