ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	138/735	423/7206	2.23650168088e-39
ko05033	Nicotine addiction	39/735	56/7206	1.5508587633e-26
ko04724	Glutamatergic synapse	62/735	152/7206	1.32661237508e-23
ko04721	Synaptic vesicle cycle	40/735	80/7206	1.67362978234e-19
ko05032	Morphine addiction	47/735	110/7206	3.94346510142e-19
ko04727	GABAergic synapse	45/735	110/7206	1.79308765117e-17
ko04728	Dopaminergic synapse	58/735	185/7206	8.56793462066e-16
ko04723	Retrograde endocannabinoid signaling	54/735	175/7206	1.87798801846e-14
ko04713	Circadian entrainment	45/735	136/7206	1.89004966753e-13
ko04725	Cholinergic synapse	48/735	160/7206	1.80621774897e-12
ko04024	cAMP signaling pathway	67/735	279/7206	9.38274011279e-12
ko04726	Serotonergic synapse	38/735	137/7206	4.64234029852e-09
ko04020	Calcium signaling pathway	59/735	265/7206	4.75199286543e-09
ko04514	Cell adhesion molecules (CAMs)	35/735	130/7206	4.36942386417e-08
ko05030	Cocaine addiction	24/735	73/7206	1.02238884696e-07
ko04911	Insulin secretion	32/735	117/7206	1.1159404609e-07
ko05031	Amphetamine addiction	27/735	91/7206	1.81353180834e-07
ko04742	Taste transduction	21/735	61/7206	2.66719092229e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	23/735	74/7206	5.91651376087e-07
ko03040	Spliceosome	1/735	145/7206	4.8393864891e-06
ko04921	Oxytocin signaling pathway	43/735	209/7206	6.64064496067e-06
ko04261	Adrenergic signaling in cardiomyocytes	42/735	205/7206	9.58634156161e-06
ko04120	Ubiquitin mediated proteolysis	1/735	138/7206	1.10895506182e-05
ko05205	Proteoglycans in cancer	9/735	271/7206	2.2915914181e-05
ko05164	Influenza A	3/735	167/7206	4.10774430281e-05
ko04010	MAPK signaling pathway	56/735	321/7206	4.33570799679e-05
ko04970	Salivary secretion	23/735	95/7206	9.23035752617e-05
ko04966	Collecting duct acid secretion	10/735	26/7206	0.000132966648132
ko04720	Long-term potentiation	23/735	99/7206	0.000137272644749
ko05203	Viral carcinogenesis	11/735	277/7206	0.000157027435778
ko05322	Systemic lupus erythematosus	3/735	151/7206	0.000178953694857
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/735	59/7206	0.000190356145704
ko03013	RNA transport	4/735	166/7206	0.000216378081623
ko04360	Axon guidance	42/735	233/7206	0.00023460148755
ko04022	cGMP-PKG signaling pathway	39/735	216/7206	0.000344844800238
ko04060	Cytokine-cytokine receptor interaction	6/735	191/7206	0.000371234017746
ko05168	Herpes simplex infection	6/735	182/7206	0.000709632391501
ko04141	Protein processing in endoplasmic reticulum	6/735	184/7206	0.000730441852382
ko04217	Necroptosis	6/735	178/7206	0.000982123894193
ko05110	Vibrio cholerae infection	15/735	63/7206	0.00132763292197
ko04621	NOD-like receptor signaling pathway	5/735	157/7206	0.00186467213086
ko04972	Pancreatic secretion	22/735	111/7206	0.00218782338654
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	17/735	79/7206	0.00234041310794
ko04976	Bile secretion	17/735	80/7206	0.00264776260179
ko04925	Aldosterone synthesis and secretion	20/735	105/7206	0.0051761440335
ko00310	Lysine degradation	1/735	73/7206	0.00584683038098
ko04932	Non-alcoholic fatty liver disease (NAFLD)	8/735	182/7206	0.00602703931035
ko04730	Long-term depression	16/735	78/7206	0.00688904745727
ko04964	Proximal tubule bicarbonate reclamation	8/735	29/7206	0.00691505985062
ko05169	Epstein-Barr virus infection	10/735	206/7206	0.00704081900646
ko05162	Measles	4/735	120/7206	0.00889195861938
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/735	14/7206	0.00995238457083
ko04930	Type II diabetes mellitus	12/735	54/7206	0.010018723821
ko05220	Chronic myeloid leukemia	2/735	85/7206	0.0106490570075
ko04260	Cardiac muscle contraction	18/735	98/7206	0.0112645921072
ko04971	Gastric acid secretion	18/735	98/7206	0.0112645921072
ko04071	Sphingolipid signaling pathway	27/735	162/7206	0.0117290996475
ko04540	Gap junction	22/735	128/7206	0.0120585578068
ko05120	Epithelial cell signaling in Helicobacter pylori infection	17/735	92/7206	0.0139373447314
ko04014	Ras signaling pathway	41/735	279/7206	0.0151214206587
ko04064	NF-kappa B signaling pathway	3/735	96/7206	0.0164329124384
ko04978	Mineral absorption	9/735	40/7206	0.0171723302877
ko05166	HTLV-I infection	18/735	292/7206	0.0176158306047
ko04924	Renin secretion	16/735	86/7206	0.0176964797035
ko04140	Autophagy - animal	8/735	164/7206	0.0185565630906
ko04640	Hematopoietic cell lineage	1/735	64/7206	0.0195221524349
ko04612	Antigen processing and presentation	2/735	77/7206	0.0216675512101
ko04218	Cellular senescence	9/735	177/7206	0.0226350768768
ko04072	Phospholipase D signaling pathway	30/735	197/7206	0.0229074118742
ko04110	Cell cycle	7/735	145/7206	0.0263880119906
ko04630	Jak-STAT signaling pathway	6/735	132/7206	0.0284522401388
ko05161	Hepatitis B	9/735	173/7206	0.0294784052497
ko04350	TGF-beta signaling pathway	4/735	103/7206	0.0315360601578
ko05140	Leishmaniasis	2/735	75/7206	0.0318801923411
ko04146	Peroxisome	3/735	89/7206	0.0322827116024
ko04710	Circadian rhythm	9/735	43/7206	0.0365717614438
ko04550	Signaling pathways regulating pluripotency of stem cells	9/735	165/7206	0.0375327860966
ko05145	Toxoplasmosis	6/735	126/7206	0.0376414658967
ko01200	Carbon metabolism	6/735	128/7206	0.0378497493559
ko04510	Focal adhesion	15/735	240/7206	0.03893512124
ko05016	Huntington's disease	13/735	215/7206	0.0392536971465
ko04015	Rap1 signaling pathway	39/735	278/7206	0.0423794724866
ko00650	Butanoate metabolism	6/735	26/7206	0.043007284171
ko05323	Rheumatoid arthritis	15/735	89/7206	0.0498867443151